Apoptosis-Inducing, TAF9-Like Domain 1 Proteins (APITD1)

This locus represents naturally occurring read-through transcription between the neighboring APITD1 (apoptosis-inducing, TAF9-like domain 1) and CORT (cortistatin) genes. Additionally we are shipping Apoptosis-Inducing, TAF9-Like Domain 1 Antibodies (36) and Apoptosis-Inducing, TAF9-Like Domain 1 Kits (15) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
APITD1 378708 Q8N2Z9
APITD1 69928 Q9D084
Rat APITD1 APITD1 100534597  
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Top Apoptosis-Inducing, TAF9-Like Domain 1 Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
$5,227.64
Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
$5,227.64
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
Details
Wheat germ Human GST tag 10 μg 11 to 12 Days
$414.29
Details
Yeast Xenopus laevis His tag   1 mg 60 to 71 Days
$2,284.33
Details
Yeast Cow His tag   1 mg 60 to 71 Days
$2,293.50
Details

APITD1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Apoptosis-Inducing, TAF9-Like Domain 1 (APITD1) Interaction Partners

Human Apoptosis-Inducing, TAF9-Like Domain 1 (APITD1) interaction partners

  1. MHF prefers branched DNA over dsDNA because it engages two duplex arms. MHF engages DNA forks or various four-way junctions independent of the junction-site structure. The DNA-binding interface of MHF is important for cellular resistance to DNA damage.

  2. The MHF complex, which is a heterotetramer that comprises two MHF1-MHF2 heterodimers, is remodeled by FANCM to favor recognition of branched DNA over dsDNA.

  3. CENP-S is not found in a soluble complex with its binding partner CENP-T but it interacts strongly and specifically with immobilized CENP-T in an in vivo binding assay.

  4. It discusses current knowledge of the biological roles of CENP-S and CENP-X and how their dual existence may be a common feature of CCAN (constitutive centromere-associated network) proteins.

  5. A long, positively charged patch exposed on the surface of the (MHF1-MHF2) complex plays a critical role in double-stranded DNA binding to chromatin.

  6. MHF1 and MHF2 form a compact tetramer to which FANCM-F binds through a 'dual-V' shaped structure.

  7. provide biochemical evidence that MHF1 and MHF2 assemble into a heterodimer that binds DNA and enhances the DNA branch migration activity of FANCM.

  8. Mutations in APITD1 is not a common abnormality of neuroblastoma tumours.

  9. These results indicate that APITD1 is not the tumor suppressor gene on 1p36 responsible for the negative prognostic effect in uveal melanoma with concurrent loss of chromosome arm 1p, region 36, and chromosome 3.

  10. Results identified a centromere protein S (CENP-S)-containing subcomplex that includes the new constitutive kinetochore protein CENP-X.

Apoptosis-Inducing, TAF9-Like Domain 1 (APITD1) Protein Profile

Protein Summary

This gene was identified in the neuroblastoma tumor suppressor candidate region on chromosome 1p36. It contains a TFIID-31 domain, similar to that found in TATA box-binding protein-associated factor, TAF(II)31, which is required for p53-mediated transcription activation. This gene was expressed at very low levels in neuroblastoma tumors, and was shown to reduce cell growth in neuroblastoma cells, suggesting that it may have a role in a cell death pathway. The protein is a component of multiple complexes, including the Fanconi anemia (FA) core complex, the APITD1/CENPS complex, and the CENPA-CAD (nucleosome distal) complex. Known functions include an involvement with chromatin associations of the FA core complex, and a role in the stable assembly of the outer kinetochore. Alternative splicing of this gene results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream cortistatin (CORT) gene, as represented in GeneID:100526739. An APITD1-related pseudogene has been identified on chromosome 7.

Gene names and symbols associated with APITD1

  • centromere protein S (CENPS)
  • centromere protein S (Cenps)
  • apoptosis-inducing, TAF9-like domain 1 (CENPS)
  • centromere protein S L homeolog (cenps.L)
  • apoptosis-inducing, TAF9-like domain 1 (APITD1)
  • centromere protein S (cenps)
  • 2610040C18Rik protein
  • 2810407L01Rik protein
  • apitd1 protein
  • CENP-S protein
  • cenps protein
  • FAAP16 protein
  • Mhf1 protein
  • zgc:194319 protein

Protein level used designations for APITD1

FANCM-interacting histone fold protein 1 , Fanconi anemia-associated polypeptide of 16 kDa , apoptosis-inducing TAF9-like domain-containing protein 1 , centromere protein S , apoptosis-inducing TAF9-like domain-containing protein 1 homolog , ortholog of human apoptosis-inducing, TAF9-like domain 1 APITD1 , CENP-S , apoptosis-inducing, TAF9-like domain 1 , FANCM associated histone fold protein 1

GENE ID SPECIES
378708 Homo sapiens
69928 Mus musculus
613732 Bos taurus
431958 Xenopus laevis
101114968 Ovis aries
100534620 Oryctolagus cuniculus
771417 Gallus gallus
100522376 Sus scrofa
100534597 Rattus norvegicus
487450 Canis lupus familiaris
569270 Danio rerio
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