Arachidonate 5-Lipoxygenase-Activating Protein Proteins (ALOX5AP)

ALOX5AP encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Additionally we are shipping ALOX5AP Antibodies (68) and ALOX5AP Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ALOX5AP 11690 P30355
Rat ALOX5AP ALOX5AP 29624 P20291
ALOX5AP 241 P20292
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online

Top ALOX5AP Proteins at

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg 50 to 55 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg 50 to 55 Days
Baculovirus infected Insect Cells Human His tag 100 μg 14 to 16 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
Wheat germ Human GST tag 10 μg 11 to 12 Days

ALOX5AP Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , ,
, , ,

More Proteins for Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP) Interaction Partners

Mouse (Murine) Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP) interaction partners

  1. Within the endothelial population, cells that transition from haemogenic endothelial to erythro-myeloid progenitors specifically express Alox5 and its co-factor Alox5ap, which control leukotriene production. Functional assays using mouse embryonic stem cells demonstrate that leukotrienes promote haematopoietic progenitor cell generation.

  2. ALOX5AP Overexpression in Adipose Tissue Leads to LXA4 Production and Protection Against Diet-Induced Obesity and Insulin Resistance

  3. Data indicate that a single amino acid mutation was sufficient to reverse the speciation observed in wild type 5-Lipoxygenase activating protein (FLAP).

  4. BRP-7 potently suppresses leukotriene biosynthesis by interacting with FLAP in mouse peritonitis model.

  5. FLAP regulates phosphorylation of tau protein via modulating GSK-3beta activity.

  6. This study demonistrated that a a novel role for FLAP in the pathogenesis of anxiety-like behavior in mice.

  7. Deletion of myeloid cell FLAP markedly attenuates the proliferative response to vascular injury, while preserving endothelial integrity.

  8. A FLAP inhibitor given during critical window periods may prevent oxygen induced aberration of pulmonary alveolarization in a dose- and time-dependent manner.

  9. the 5-LO pathway emerges early during embryonic stem cell differentiation into cells of the myeloid lineage

  10. Adipose tissue from obese mice, compared with that from lean mice, exhibited increased 5-LO activating protein

  11. Data show that 5-lipoxygenase activity increases during senescence-like growth arrest via a p53/p21-dependent pathway in both human and mouse embryo fibroblasts.

  12. Altered 5-lipoxygenase is associated with obesity and bone traits

  13. This observation supports the hypothesis that 5-LO may be involved in diseases of the brain associated with aging.

  14. Important role of FLAP/leukotriene pathway in adaptive immunological circuits in vascular and adipose tissue inflammation. May be key regulator of T-cell-driven inflammatory and possible target in treatment of atherosclerosis and metabolic disease.

  15. identify multiprotein complexes for leukotriene synthesis on the outer and inner nuclear membranes of mast cells and neutrophils, centered on the 5-Lipoxygenase-Activating Protein and 5-Lipoxygenase

  16. FLAP mRNA is abundantly expressed in fetal mouse liver from e11.5 until delivery.

Human Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP) interaction partners

  1. Data support the conclusion that the presence of FLAP reduces triple K mutant-5-LOX product formation to wild type-5-LOX levels.

  2. Our study showed that ALOX5AP rs10507391 was associated with total cholesterol (TC) levels but we didn't observe any association between rs10507391 and the risk of myocardial infarction

  3. Two-stage association study to screen the positive CpG-SNPs of ALOX5AP gene, then explored the relationship among CpG-SNPs, methylation levels, and mRNA expression levels. Findings showed that CpG-SNP rs4073259 associated with ischemic stroke affected DNA methylation and then regulated the mRNA expression via allele-specific DNA methylation.

  4. This meta-analysis indicates that ALOX5AP rs17222919-1316T/G may be a protective factor against stroke.

  5. Indicate a potential protective role of ALOX5AP and 5-arachidonate lipoxygenase gene in diabetes type 2 pathogenesis.

  6. No significant association was found between ALOX5AP rs10507391 polymorphism and ischemic stroke risk in males. Moreover, ALOX5AP rs10507391 polymorphism was not associated with cardioembolic ischemic stroke risk.

  7. rs17222919 of ALOX5AP is a potential genetic protective factor against ischemic stroke in the Chinese population

  8. This study revealed that epistatic interaction among the ALOX5, ALOX5AP and MPO genes played a significant role in vulnerability to ischemic stroke.

  9. The results the study indicate that SNP genetic variants of ALOX5AP might play a role in the development of SSc-related pulmonary fibrosis and ventilatory dysfunction.

  10. The observation that the coexpression of FLAP with a subset of the 5-LOX mutants restores 5-LOX-wild-type (wt)-like levels of products formed in intact cells suggests a physical protein-protein interaction, beyond colocalization, of 5-LOX and FLAP.

  11. Meta-analysis suggests that the A allele at the ALOX5AP SG13S114 polymorphism is a protective factor for the ischemic stroke in the European population

  12. Genetic polymorphisms of T-1131C APOA5 and ALOX5AP SG13S114 can be considered risk factors for the susceptibility to ischemic stroke in Morocco.

  13. Data indicate that a single amino acid mutation was sufficient to reverse the speciation observed in wild type 5-Lipoxygenase activating protein (FLAP).

  14. No association was found between single-nucleotide polymorphisms of ALOX5AP or PDE4D and the risk of overall ischemic stroke in a southeastern Chinese population. The ALOX5AP gene might be related to ischemic stroke incidence in females.

  15. Genetic interaction of CD80 and ALOX5AP was observed in systemic lupus erythematosus in Asian populations.

  16. findings show that several enzymes known to be involved in the biosynthesis of proinflammatory LTs, such as FLAP and cPLA2alpha, also contribute to LX and Rv formation

  17. The results of this study supported the association of the epistatic interactions of ALOX5AP, THBD, and KNG1 and present novel evidence for the main effect of KNG1 gene on IS susceptibility

  18. results of the meta-analysis indicate that ALOX5AP rs10507391/SG13S114 A>T polymorphism is not associated with the risk of cerebral infarction in the Chinese population.

  19. Genetic polymorphisms of ALOX5AP and CYP3A5 increase susceptibility to ischemic stroke and are associated with atherothrombotic events in stroke patients.

  20. Our study provides evidence that the promoter single nucleotide polymorphism (SNP) rs17222919 of the ALOX5AP is a potential genetic protective factor for IS in the Chinese Han population.

Cow (Bovine) Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP) interaction partners

  1. ALOX5AP, CPNE3, IL1R2, IL6, TLR2, TLR4, and THY1 were upregulated in blood polymorphonuclear cells in negative energy balance versus positive energy balance cows.

ALOX5AP Protein Profile

Protein Summary

This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Gene names and symbols associated with ALOX5AP

  • arachidonate 5-lipoxygenase-activating protein (alox5ap)
  • arachidonate 5-lipoxygenase activating protein (ALOX5AP)
  • arachidonate 5-lipoxygenase activating protein (alox5ap)
  • arachidonate 5-lipoxygenase activating protein (Alox5ap)
  • al5ap protein
  • ALOX5AP protein
  • fj65d02 protein
  • FLAP protein
  • wu:fj65d02 protein
  • zgc:63982 protein

Protein level used designations for ALOX5AP

arachidonate 5-lipoxygenase-activating protein , Arachidonate 5-lipoxygenase-activating protein , MK-886-binding protein , arachidonate 5 lipoxygenase activating protein , 5-lipoxygenase-activating protein FLAP , FLAP , arachidonate 5-lipoxygenase activating protein , 5-lipoxygenase-activating protein

337376 Danio rerio
452520 Pan troglodytes
477323 Canis lupus familiaris
613083 Xenopus (Silurana) tropicalis
770904 Gallus gallus
100286557 Salmo salar
100305320 Oncorhynchus mykiss
100009413 Oryctolagus cuniculus
443326 Ovis aries
11690 Mus musculus
29624 Rattus norvegicus
241 Homo sapiens
613869 Bos taurus
100034178 Equus caballus
397392 Sus scrofa
713170 Macaca mulatta
Selected quality suppliers for ALOX5AP Proteins (ALOX5AP)
Did you look for something else?