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GTPase-activating protein. Additionally we are shipping AGAP1 Antibodies (39) and many more products for this protein.
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The effect of AGAP1 Knockdown could be rescued by FLAG-AGAP1, but not by an AGAP1 mutant that did not bind Kif2A efficiently, ArfGAP1-HA or Kif2A-GFP. The results support the hypothesis that the Kif2A.AGAP1 complex contributes to control of cytoskeleton remodeling involved in cell movement.
GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity.
overexpression inhibited formation of platelet-derived growth factor-induced ruffles and also induced loss of actin stress fibers
AGAP1 is a novel binding partner of nitric oxide-sensitive guanylyl cyclase
CENTG2 is an intriguing candidate gene that merits further scrutiny for its role in autism.
The AGAP1 has been found to associate with the adaptor protein complex AP-3 and regulate the function of AP-3 endosomes.
AGAP1 is unique among the AZAPs in its specificity for Arf1, and this activity is dependent on its NH(2)-terminal GTPase-like domain. AGAP1 induce reciprocal activation of Arf6.
The elimination of adaptor protein 3 or abrogation of AGAP1-M5 muscarinic receptor interaction in vivo decreased the magnitude of presynaptic M5 muscarinic receptor mediated dopamine release potentiation in the striatum.
GTPase-activating protein. Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system (By similarity).
centaurin, gamma 2
, centaurin, gamma 3
, arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1
, ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
, ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
, arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1-like
, centaurin, gamma 2-like
, Arf GAP with GTP-binding protein-like, ANK repeat and PH domains 1
, GTP-binding and GTPase-activating protein 1