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The protein encoded by ARAP1 contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. Additionally we are shipping ARAP1 Antibodies (45) and many more products for this protein.
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Quantitative trait loci genes analysis reveals association between T2D risk variants at the ARAP1/STARD10 (show STARD10 Proteins) locus and STARD10 (show STARD10 Proteins) but not ARAP1 expression.
Increased ARAP (show INS Proteins)1 expression might contribute to type 2 diabetes susceptibility at this Genome-wide association studies locus.
Arap1 is highly expressed in the renal vasculature, and its expression is suppressed by angiotensin II.
afadin regulates the cyclical activation and inactivation of Rap1 (show TERF2IP Proteins), Rac1, and RhoA (show RHOA Proteins) through SPA-1 and ARAP1.
Genetic variant rs1552224 of CENTD2 on chromosome 11 contributes to an independent effect as well as joint cumulative effect with rs2237897 of KCNQ1 on the risk of type 2 diabetes mellitus in Chinese Han population.
The proinsulin (show INS Proteins)-decreasing and T2D-risk Alleles are associated with increased ARAP1 mRNA levels in primary human pancreatic islets.
a novel molecular mechanism of circular dorsal ruffles ring size control through the ARAP1-Arf1 (show ARF1 Proteins)/5 pathway.
Of the lead variants from 12 novel type 2 diabetes associated loci, CENTD2 significantly associated with increased plasma glucose values and decreased glucose-stimulated insulin (show INS Proteins) release.
ARAP1 associated with CIN85 (show SH3KBP1 Proteins) affects epidermal growth factor receptor (show EGFR Proteins) endocytic trafficking
PTK6 (show PTK6 Proteins) enhances EGFR (show EGFR Proteins) signaling by inhibition of EGFR (show EGFR Proteins) down-regulation through phosphorylation of ARAP1 in breast cancer cells.
ARAP1 acts primarily on Arf6 (show ARF6 Proteins) in vivo.
ARAP1 knockdown significantly compromises the localization of death receptor 4 at the cell surface of several tumor cell lines and slows down their TRAIL-induced death.
The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
centaurin delta 2
, centaurin, delta 2
, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
, arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
, ARF-GAP, RHO-GAP, ankyrin repeat, and pleckstrin homology domains-containing protein 1