Aryl Hydrocarbon Receptor Interacting Protein Proteins (AIP)

The protein encoded by AIP is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. Additionally we are shipping AIP Antibodies (108) and AIP Kits (21) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
AIP 9049 O00170
AIP 11632 O08915
AIP 282827 Q5FWY5
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Top AIP Proteins at

Showing 9 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
Escherichia coli (E. coli) Human His tag 100 μg 15 to 19 Days
Wheat germ Human GST tag 10 μg 11 to 12 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
Escherichia coli (E. coli) Human Un-conjugated SDS-PAGE analysis of Human AIP Protein. 100 μg 11 to 18 Days
Yeast Cow His tag   1 mg 60 to 71 Days
Yeast Rat His tag   1 mg 60 to 71 Days
Yeast REACT_Green monkey His tag   1 mg 60 to 71 Days

AIP Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Aryl Hydrocarbon Receptor Interacting Protein (AIP) Interaction Partners

Human Aryl Hydrocarbon Receptor Interacting Protein (AIP) interaction partners

  1. lack of AIP hinders the upregulation of PDE4A8 and PDE4A4 protein seen in sporadic somatotrophinomas.

  2. The novel missense mutation in the AIP gene, p.T171I, identified in a Chinese growth hormone (GH)-secreting Familial Isolated Pituitary Adenoma case, is a pathogenic variant that stimulated tumor cell proliferation and invasiveness and GH hypersecretion. The AIP-SSTR2-ZAC1 and AIP-IL-6-STAT3 pathways might be involved in these cell processes.

  3. AIP mutation is associated with familial pituitary adenoma syndromes.

  4. A missense variant in aryl hydrocarbon receptor-interacting protein (AIP) gene and a truncating mutation in multiple endocrine neoplasia I protein (MEN1) gene were both detected in the proband and his father, showing limited co-segregation with phenotype.

  5. The array was immunoscreened with serum from the patient in dilution 1:2000, and a strong signal on the array was identified as AIPL1, a protein with expression specifically restricted to the retina and the pineal gland.

  6. Earlier diagnosis of AIP-related acromegaly-gigantism cases enables timely clinical evaluation and treatment, thereby improving outcomes in terms of excessive linear growth and acromegaly comorbidities--{REVIEW}

  7. Therefore, both functional and structural studies reveal that N-terminus mutations in the AIP gene alter protein behaviour significantly and hence can truly be pathogenic in nature.

  8. This study of human fibroblasts bearing endogenous heterozygous AIP mutations and transfected pituitary GH3 cells shows that AIP mutations affect the AIP protein level and alter AhR transcriptional activity in a gene- and tissue-dependent manner.

  9. The expression of PDE4A4 and PDE4A8 in normal pituitary, their increased expression in adenomatous pituitary cells where AIP is meant to participate, and the disruption of the PDE4A4-AIP interaction by AIP mutants may play a role in pituitary tumorigenesis.

  10. The aryl hydrocarbon receptor interacting protein (AIP) founder mutation R304(*) is frequent in Mid Ulster, resulting in numerous acromegaly/gigantism cases.

  11. the well-known interaction between AIP and 2 different isoforms of phosphodiesterases (PDEs), PDE2A3 and PDE4A5, is of particular interest. While the interaction with over-expressed AIP does not seem to affect PDE2A3 function, the reported effect on PDE4A5 is, in contrast, reduced enzymatic activity.

  12. The c.805_825dup allele in AIP, originating from a common ancestor, associates with a severe clinical phenotype of gigantism.

  13. p.R3O4Q mutation, p.R304* mutation, and IVS3+1G>A mutation found in acromegaly cases

  14. The prevalence of AIP mutations in young Mexican patients with acromegaly is similar to that of European cohorts.

  15. Enhanced proteasomal degradation is a novel pathogenic mechanism for AIPmuts, with direct implications for the phenotype in pituitary adenomas.

  16. Case Report: truncating AIP mutation, p.W279*, in father/daughter presenting with familial isolated pituitary adenoma.

  17. A modest relationship was found between PPARalpha and AIP expression, both being significantly higher in the presence of pre-operative somatostatin analogues in somatotropinoma patients.

  18. The prevalence of AIP(mut) in Turkish patients was found to be 1 % in sporadic acromegaly in the present study.

  19. No digenism with AIP was identified among patients with sporadic pituitary adenomas.

  20. The aim of this study was to examine mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene

Mouse (Murine) Aryl Hydrocarbon Receptor Interacting Protein (AIP) interaction partners

  1. Results demonstrated that Aip inactivation promoted somatotroph tumorigenesis and overproduction of growth hormone probably through increased Stat3 activation.

  2. Results provide novel evidence that AIP has an important role in the regulation of cAMP synthesis.

  3. XAP2 exerts a negative effect on ERalpha transcriptional activity and may thus prevent ERalpha-dependent events.

  4. Developmental control of apoptosis by the immunophilin aryl hydrocarbon receptor-interacting protein (AIP) involves mitochondrial import of the survivin protein

  5. Mice with inactivation of aryl hydrocarbon receptor-interacting protein display complete penetrance of pituitary adenomas with aberrant ARNT expression.

  6. Data show that AIP is not required for the induction of the Cyp1a1 and Cyp1a2 genes.

  7. XAP2 hinders importin beta binding to the mAhR complex and represses the transactivation potential of the AhR by stabilizing the receptor complex and/or blocking nucleocytoplasmic shuttling of the AhR complex

  8. PPARalpha is in a complex with hsp90 and XAP2, and XAP2 appears to function as a repressor

  9. XAP2 has a role in stabilization of the dioxin receptor

  10. The role of Xap2 and C-terminal hsp-70 interacting protein on the endogenous Ah receptors expressed in mouse cell lines was determined.

  11. the role of ARA9 in cardiac development is independent of its interactions with its known xenobiotic receptor partners.

  12. expression level of ARA9 correlates with the frequency of a phenocopy of the Ahr-null allele supports the conclusion that the ARA9 protein is essential for AHR signaling during development

  13. XAP2 affects triiodothyronine-transcriptional repression of the hypothalamic gene, throtropin releasing hormone.

AIP Protein Profile

Protein Summary

The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus.

Gene names and symbols associated with AIP

  • aryl hydrocarbon receptor interacting protein (AIP)
  • aryl hydrocarbon receptor interacting protein (aip)
  • aryl hydrocarbon receptor interacting protein (Aip)
  • aryl-hydrocarbon receptor-interacting protein (Aip)
  • AA408703 protein
  • AIP protein
  • Ara9 protein
  • AW476050 protein
  • D19Bwg1412e protein
  • Fkbp16 protein
  • FKBP37 protein
  • SMTPHN protein
  • wu:fa03h10 protein
  • xaip protein
  • XAP-2 protein
  • Xap2 protein
  • zgc:101101 protein

Protein level used designations for AIP

aryl hydrocarbon receptor interacting protein , AH receptor-interacting protein-like , AH receptor-interacting protein , HBV X-associated protein 2 , immunophilin homolog ARA9 , aryl-hydrocarbon receptor-interacting protein , HBV-X associated protein , immunophilin XAP2

451371 Pan troglodytes
100124770 Xenopus (Silurana) tropicalis
100407721 Callithrix jacchus
9049 Homo sapiens
334795 Danio rerio
395123 Gallus gallus
610467 Canis lupus familiaris
360190 Bos taurus
100723913 Cavia porcellus
101119947 Ovis aries
11632 Mus musculus
282827 Rattus norvegicus
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