Ash2 (Absent, Small, Or Homeotic)-Like (Drosophila) Proteins (ASH2L)

Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. Additionally we are shipping ASH2L Antibodies (110) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ASH2L 9070 Q9UBL3
ASH2L 23808 Q91X20
Rat ASH2L ASH2L 290829  
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Top ASH2L Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
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Escherichia coli (E. coli) Human His-SUMO Tag 100 μg Log in to see 11 Days
$411.40
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
$888.80
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ASH2L Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Mouse (Murine)

More Proteins for Ash2 (Absent, Small, Or Homeotic)-Like (Drosophila) (ASH2L) Interaction Partners

Human Ash2 (Absent, Small, Or Homeotic)-Like (Drosophila) (ASH2L) interaction partners

  1. berrant histone methylation of IFN-gamma associating H3K4me3 and H3K27me3 caused by over-binding of Ash2L and Jmjd3 might be involved in immune dysfunction and vascular damage in Kawasaki disease in the acute phase.

  2. our results suggest that ASH2L contributes to leukemogenesis by cooperating with other proteins that aberrantly upregulate cellular growth and proliferation pathways.

  3. different cancer mutations in MLL1 lead to a loss or increase in activity, illustrating the complex and tumor-specific role of MLL1 in carcinogenesis.

  4. Overall, epigenetic modulation is a promising approach to evaluate the role of chromatin structure for the radioresponsiveness of glioma cell lines.

  5. Data suggest an interplay between megakaryocytic leukemia 1 (MKL1) and ASH2 protein to promote tumor necrosis factor alpha (TNF-alpha) induced proinflammatory transcription in macrophages.

  6. the histone methyltransferase core enzyme ASH2L was bound at EGFR in the germinal matrix and in gliomas where levels of H3K4me3 are high, and the histone acetyltransferase P300 was bound in samples with H3K27ac enrichment

  7. Ash2L acts in concert with P53 promoter occupancy to activate RNA Polymerase II by aiding formation of a stable transcription pre-initiation complex required for its activation.

  8. ASH2L enhances ERalpha expression as a coactivator of GATA3 in breast cancers

  9. Non active site mutations in the MLL1 SET domain render the protein defective for H3K4 dimethylation by the MLL1 core complex, which is associated with a loss of the ability of MLL1 to interact with WRAD or with the RbBP5/Ash2L heterodimer.

  10. Data indicate that MLL1 methylates Ash2L in the absence of histone H3, but only when assembled within a complex with WDR5 and RbBP5.

  11. H2B dependent regulation of MLL family histone methylatransferases depends on the N-terminal WH motif of ASH2L.

  12. crystal structure of the C-terminal SPRY domain of human Ash2L

  13. The structure shows that Ash2L contains an atypical PHD finger that does not have histone tail-binding activity.

  14. ASH2L binds DNA using a forkhead-like helix-wing-helix (HWH) domain.

  15. NF-Y acts upstream of H3K4me3 deposition by recruiting Ash2L

  16. Protein-arginine methyltransferase 1 (PRMT1) methylates Ash2L, a shared component of mammalian histone H3K4 methyltransferase complexes.

  17. Data suggest that both Ash2L/RbBP5 and the MLL1 SET domain make direct contacts with the substrates and contribute to the formation of a joint catalytic center.

  18. Results show that Depletion of CHD8 enhances HOXA2 expression and a loss of the WDR5/Ash2L/RbBP5 subcomplex.

  19. Ash2l and Saf-A are recruited to the inactive X chromosome at the onset of stable X inactivation.

  20. high dimethylation of histone H3 at lysine 4 expression is rare in hepatocellular carcinoma compared with other carcinomas, possibly due to complex epigenetic regulation involving Ash2

Mouse (Murine) Ash2 (Absent, Small, Or Homeotic)-Like (Drosophila) (ASH2L) interaction partners

  1. Ash2l-1 and Ash2l-2 are involved in the maintenance of mESCs pluripotency and the regulation of genomic H3K4me3.

  2. We discuss the implications of these results to understand the role of ASH2L and Xist repeat E for histone modifications and escape gene regulation during random X-chromosome inactivation.

  3. ASH2L enhances ERalpha expression as a coactivator of GATA3 in breast cancers

  4. Ash2l is essential for pluripotency and maintaining open chromatin in embryonic stem cells

  5. Tbx1 and Ash2l have overlapping mRNA and protein expression patterns during development.

  6. Several candidate targets of complexes containing Ap2delta and Ash2l were identified that can be used to further elucidate their roles during development and showed that Fgfr3 is a novel direct target of these complexes.

  7. Ap2delta associates with ASH2L and MLL2 (ALR), forming a complex that methylates lysine 4 of histone H3.

ASH2L Protein Profile

Protein Summary

Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis (By similarity).

Gene names and symbols associated with ASH2L

  • ASH2 like histone lysine methyltransferase complex subunit (ASH2L)
  • ash2 (absent, small, or homeotic)-like (Drosophila) (Ash2l)
  • ash2 (absent, small, or homeotic)-like (Drosophila) (ash2l)
  • ash2 (absent, small, or homeotic)-like L homeolog (ash2l.L)
  • ASH2 like histone lysine methyltransferase complex subunit (Ash2l)
  • ASH2 protein
  • ash2-like protein
  • ASH2L protein
  • ASH2L1 protein
  • ASH2L2 protein
  • Bre2 protein
  • fb34c06 protein
  • fe38b04 protein
  • fi20h02 protein
  • wu:fb34c06 protein
  • wu:fe38b04 protein
  • wu:fi20h02 protein
  • zgc:171444 protein

Protein level used designations for ASH2L

ASH2-like protein , set1/Ash2 histone methyltransferase complex subunit ASH2 , ash2-like

GENE ID SPECIES
9070 Homo sapiens
23808 Mus musculus
426774 Gallus gallus
558193 Danio rerio
699382 Macaca mulatta
100127317 Xenopus laevis
290829 Rattus norvegicus
475589 Canis lupus familiaris
100138350 Bos taurus
100732899 Cavia porcellus
100059465 Equus caballus
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