anti-Asp (Abnormal Spindle) Homolog, Microcephaly Associated (Drosophila) (ASPM) Antibodies

ASPM is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. Additionally we are shipping and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
Anti-Rat ASPM ASPM 289054  
ASPM 259266 Q8IZT6
Anti-Mouse ASPM ASPM 12316 Q8CJ27
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-ASPM Antibodies at antibodies-online.com

Showing 10 out of 19 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated IHC, IHC (p) Anti-ASPM antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN960544 concentration 5 ug/ml. Anti-ASPM antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg 11 to 14 Days
$727.83
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from various samples, using ASPM Antibody. Lane 1: 293 treated with blocking peptide. Lane 2: 293; Lane 3: Hela; Western blot analysis of ASPM using HeLa whole cell lysates 100 μL 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated ICC, IF ASPM / MCPH5 antibody tested by immunofluorescence. Top right: HeLa cells stained with ASPM / MCPH5 antibody (2 µg/ml). Top left: Same cells stained with alpha Tubulin mAb (Clone 5-B-1-2). Bottom left: Stained with DAPI. Bottom right: Merge of all 3 images. ASPM / MCPH5 antibody tested by immunofluorescence. Top right: HeLa cells stained with ASPM / MCPH5 antibody (2 µg/ml). Top left: Same cells stained with alpha Tubulin mAb (Clone 5-B-1-2). Bottom left: Stained with DAPI. Bottom right: Merge of all 3 images. 100 μg 1 to 2 Days
$507.50
Details
Human Rabbit Un-conjugated IHC (p)   100 μL 11 to 13 Days
$335.04
Details
Human Rabbit Un-conjugated WB Western blot analysis ASPM using HeLa whole cell lysates. 100 μg 11 to 18 Days
$440.62
Details
Human Rabbit Un-conjugated IHC, ELISA   100 μg 11 to 16 Days
$661.57
Details
Human Rabbit Un-conjugated ICC, IF   100 μL 11 to 14 Days
$625.17
Details
Human Rabbit Biotin ELISA   100 μg 11 to 16 Days
$469.05
Details
Human Rabbit FITC ELISA   100 μg 11 to 16 Days
$469.05
Details
Human Rabbit HRP ELISA   100 μg 11 to 16 Days
$469.05
Details

Top referenced anti-ASPM Antibodies

  1. Human Polyclonal ASPM Primary Antibody for ICC, IF - ABIN250665 : Griffith, Walker, Martin, Vagnarelli, Stiff, Vernay, Al Sanna, Saggar, Hamel, Earnshaw, Jeggo, Jackson, ODriscoll: Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling. in Nature genetics 2008 (PubMed)
    Show all 5 Pubmed References

More Antibodies against ASPM Interaction Partners

Human Asp (Abnormal Spindle) Homolog, Microcephaly Associated (Drosophila) (ASPM) interaction partners

  1. in three colorectal cancers and two gastric cancers, observed ASPM somatic mutations, which consisted of a frameshift mutation by deletion of one base (c.5149delA (p. Ile1717fsX1)) or another frameshift mutation by duplication of one base (c.5149delA (p. Ile1717AsnfsX24)) in the A7 repeat

  2. ASPM-related microcephaly is not systematically associated with intellectual deficiency.

  3. downregulation of ASPM expression pronouncedly attenuated the proliferation, colony formation, and the invasive behavior of PCA cells, and dramatically reduced the number of ALDH(+) CSCs and inhibited cancer stemness and tumorigenicity. Mechanistically, ASPM interacts with disheveled-3 (Dvl-3), a cardinal upstream regulator of canonical Wnt signaling, and inhibits its proteasome-dependent degradation

  4. The c.7543C>T (p.Arg2515Ter) mutation in ASPM is a novel pathogenic mutation for the typical MCPH phenotype in this family

  5. ASPM protein is a spindle pole-focusing factor that functions redundantly with CDK5RAP2.

  6. Whole exome sequencing in one family revealed a novel 1-bp deletion NM_018136.4: c.10013delA (p.Asp3338Valfs*2), while the other family showed a previously reported nonsense mutation NM_018136.4: c.9730C>T (rs199422195 (p.Arg3244*)) in ASPM gene. The novel frame-shift mutation (p.Asp3338Valfs*2) in ASPM presumably truncates the protein synthesis that results in loss of armadillo-type fold domain.

  7. Using homozygosity mapping complemented with whole-exome, gene panel or Sanger sequencing, we identified 12 novel mutations in 3 known MCPH-associated genes - 9 in ASPM, 2 in MCPH1 and 1 in CDK5RAP2. The 2 MCPH1 mutations were homozygous microdeletions of 164,250 and 577,594 bp, respectively, for which we were able to map the exact breakpoints

  8. Abnormal cortical development in primary microcephaly was recapitulated with organoid culture in vitro using patient's induced pluripotent stem cells with ASPM mutation.

  9. Our study enlarges the collection of mutation data in ASPM-related microcephaly and offers new insight into the types and frequencies of the ASPM mutations. Further, our data highlight the clinical and imaging variability in patients with the same causative mutation, suggesting the involvement of additional (epigenetic) factors besides the primary locus.

  10. ASPM-katanin complex controls microtubule disassembly at spindle poles and that misregulation of this process can lead to microcephaly.

  11. in this study we have provided evidence that ASPM controls spindle orientation by regulating the dynamics of astral MT and that CITK is a critical downstream partner of ASPM for this activity.

  12. Through co-expression analysis, ASPM was identified and validated in association with the progression of Hepatitis C virus cirrhosis probably by regulating tumor-related phosphorylation.

  13. The results confirm that mutations in ASPM or WDR62 are the major cause of autosomal recessive primary microcephaly in the Pakistani population.

  14. A novel homozygous splice-site variant in the ASPM gene was identified. The variant is predicted to have an effect on splicing. Human Splice Finder, an in silico tool, predicted skipping of exon 16 due to this variant. Skipping of exon 16 may change the order and number of IQ motifs in the ASPM protein leading to typical autosomal recessive primary microcephaly phenotype.

  15. contrary to current opinion, the cortical volume and surface area of patients with ASPM mutations is reduced depending on a regionally specific fashion and their cognitive profile reflects this heterogeneity.

  16. Suberoylanilide hydroxamic acid enhanced the expression of malignant genes such as ASPM in lung cancer cells remaining after treatment, creating a more drug-resistant state.

  17. Gene-level tests showed that DRD2 was associated with vocabulary, ASPM with vocabulary and reading decoding, and AVPR1A with all three endophenotypes.

  18. ASPM mutations in primary autosomal recessive microcephaly patients in ethnically diverse patients

  19. microcephalin and ASPM expression are deregulated in epithelial ovarian cancer progression

  20. ASPM promotes aggressiveness of pancreatic ductal adenocarcinoma (PDAC) by maintaining Wnt-beta-catenin signaling and stem cell features of PDAC cells.

Mouse (Murine) Asp (Abnormal Spindle) Homolog, Microcephaly Associated (Drosophila) (ASPM) interaction partners

  1. in this study we have provided evidence that ASPM controls spindle orientation by regulating the dynamics of astral MT and that CITK is a critical downstream partner of ASPM for this activity.

  2. Aspm and Wdr62 interact genetically to control brain size, with mice lacking Wdr62, Aspm, or both showing gene dose-related centriole duplication defects that parallel the severity of the microcephaly and increased ectopic basal progenitors, suggesting premature delamination from the ventricular zone.

  3. Interaction between ASPM and the Cdk2/Cyclin E complex regulated the Cyclin activity by modulating its ubiquitination and localization into the nucleus.

  4. Aspm, a gene that is mutated in familial microcephaly, regulates postnatal neurogenesis in the cerebellum and supports the growth of medulloblastoma, the most common malignant pediatric brain tumor.

  5. Aspm is essential to the proliferation and differentiation of neural stem/progenitor cells. The Aspm gene loss model provided a novel pathogenetic insight into acquired microcephaly, which can be caused by in utero exposure teratogens.

  6. ASPM plays a critical role in meiotic spindle assembly and meiotic progression in mouse oocytes.

  7. AspM is expressed by proliferating cells of the adult mouse SVZ that can generate neuroblasts fated to become olfactory bulb neurons

  8. knockdown of Aspm results in decreased Wnt-mediated transcription

  9. truncated Aspm proteins cause a massive loss of germ cells, resulting in a severe reduction in testis and ovary size accompanied by reduced fertility

  10. tissue distribution of Calmbp1 in fetal and adult mice

  11. evolutionary selection of specific segments of the ASPM sequence strongly relates to differences in cerebral cortical size

  12. Aspm is crucial for maintaining a cleavage plane orientation that allows symmetric, proliferative divisions of neuroepithelial cells during brain develo

  13. NS5A protein down-regulates the expression of spindle gene Aspm through PKR-p38 signaling pathway

ASPM Antigen Profile

Protein Summary

This gene is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. Studies in mouse also suggest a role of this gene in mitotic spindle regulation, with a preferential role in regulating neurogenesis. Mutations in this gene are associated with microcephaly primary type 5. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with ASPM

  • abnormal spindle microtubule assembly (Aspm) antibody
  • abnormal spindle microtubule assembly (ASPM) antibody
  • abnormal spindle microtubule assembly (aspm) antibody
  • asp (abnormal spindle)-like, microcephaly associated (Drosophila) (Aspm) antibody
  • ASP antibody
  • ASPM antibody
  • Calmbp1 antibody
  • D330028K02Rik antibody
  • MCPH5 antibody
  • Sha1 antibody

Protein level used designations for ASPM

asp (abnormal spindle) homolog, microcephaly associated , calmodulin binding protein 1 , asp (abnormal spindle)-like, microcephaly associated , asp (abnormal spindle) homolog, microcephaly associated (Drosophila) , Abnormal spindle-like microcephaly-associated protein homolog , abnormal spindle-like microcephaly-associated protein , abnormal spindle-like microcephaly-associated protein homolog , abnormal spindle-like microcephaly protein , calmodulin-binding protein 1 , calmodulin-binding protein Sha1 , spindle and hydroxyurea checkpoint abnormal protein

GENE ID SPECIES
289054 Rattus norvegicus
424354 Gallus gallus
449566 Pan troglodytes
100232605 Taeniopygia guttata
100379990 Xenopus (Silurana) tropicalis
259266 Homo sapiens
534849 Bos taurus
493695 Felis catus
443284 Ovis aries
480009 Canis lupus familiaris
711153 Macaca mulatta
12316 Mus musculus
Selected quality suppliers for anti-ASPM (ASPM) Antibodies
Did you look for something else?