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ASPN encodes a cartilage extracellular protein that is member of the small leucine-rich proteoglycan family. Additionally we are shipping Asporin Kits (39) and Asporin Proteins (5) and many more products for this protein.
Showing 10 out of 49 products:
Human Polyclonal Asporin Primary Antibody for ICC, IF - ABIN250383
Yang, Nyalwidhe, Guo, Drake, Semmes: Targeted identification of metastasis-associated cell-surface sialoglycoproteins in prostate cancer. in Molecular & cellular proteomics : MCP 2011
Show all 2 Pubmed References
Human Polyclonal Asporin Primary Antibody for ICC, IF - ABIN4281912
Murphy, Dowling, Zweyer, Mundegar, Henry, Meleady, Swandulla, Ohlendieck: Proteomic analysis of dystrophin deficiency and associated changes in the aged mdx-4cv heart model of dystrophinopathy-related cardiomyopathy. in Journal of proteomics 2016
ASPN D15 (show MRPL16 Antibodies) is associated with increased risk of symmetrical hand osteoarthritis particularly in individuals with low variation in work tasks.
we found that asporin can be downregulated by bone morphogenetic protein 4 (show BMP4 Antibodies) in Hs578T cells and its upregulation may be facilited by serum-free cultivation or by three dimensional growth
Asporin promotes epithelial mesenchymal transformation, invasion, and migration of pancreatic cancer cellss by activating CD44 (show CD44 Antibodies)-AKT (show AKT1 Antibodies)/ERK (show EPHB2 Antibodies)-NF-kappaB (show NFKB1 Antibodies) pathway in paracrine and autocrine manner.
High ASPN expression in stroma is associated with prostate cancer progression.
To test the associations of ASPN variations with risk of subsequent oncologic outcomes.
Collectively, our findings indicate that ASPN is upregulated and plays an oncogenic role in gastric cancer progression and metastasis by influencing the EGFR (show EGFR Antibodies) signaling pathway.
Our results showed that ASPN rs13301537 T to C change and variant C genotype may contribute to knee OA risk in a Chinese Han population.
this is the first case-control study in Mexican women that suggests that menopause and the D-repeat polymorphism in the ASPN gene are associated with knee OA
Osteomodulin (show OMD Antibodies), osteoglycin (show OGN Antibodies), and asporin appear to be distinctly regulated in osteoarthritis labrum compared to OA cartilage.
Asporin may represent a new therapeutic target molecule for the development of drugs aimed at manipulating the cancer microenvironment.
Asporin deficiency changes skin glycosaminoglycan composition, and decorin (show DCN Antibodies) and biglycan (show BGN Antibodies) content, which may explain the changes in skin mechanical properties.
inhibition of TLR2 (show TLR2 Antibodies)- and TLR4 (show TLR4 Antibodies)-induced inflammatory responses and binding abilities to TLR2 (show TLR2 Antibodies) and TLR4 (show TLR4 Antibodies)
positively regulates FGF-2 (show FGF2 Antibodies) activity through a direct interaction
Findings suggest that asporin is one of the important cartilage matrix proteins that binds to the ECM (show MMRN1 Antibodies) and TGF-beta1 (show TGFB1 Antibodies) and thereby modulates interactions between TGF-beta (show TGFB1 Antibodies) and its signaling receptors.
PLAP-1/asporin plays a specific role in the periodontal ligament as a negative regulator of cytodifferentiation and mineralization by regulating BMP-2 (show BMP2 Antibodies) activity to prevent the periodontal ligament from developing non-physiological mineralization
The findings indicate that TGF-beta1 (show TGFB1 Antibodies) induces ASPN through Smad3 (show SMAD3 Antibodies) but that this induction is indirect.
Leucine-rich repeat motif 5 (LRR5) of PLAP-1/asporin, plays an important role in the PLAP-1/asporin-BMP-2 (show BMP2 Antibodies) interaction.
The small leucine-rich repeat secreted protein Asporin induces eyes in Xenopus embryos through the IGF signalling pathway.
Mapping of the OGN (show OGN Antibodies) and ASPN genes and association with growth and carcass traits.
This gene encodes a cartilage extracellular protein that is member of the small leucine-rich proteoglycan family. The encoded protein may regulate chondrogenesis by inhibiting transforming growth factor-beta 1-induced gene expression in cartilage. This protein also binds collagen and calcium and may induce collagen mineralization. Polymorphisms in the aspartic acid repeat region of this gene are associated with a susceptibility to osteoarthritis. Alternate splicing results in multiple transcript variants.
asporin (LRR class 1)
, asporin proteoglycan
, periodontal ligament associated protein 1
, small leucine-rich protein 1C
, biglycan-like protein 3
, periodontal ligament-associated protein 1