anti-B-Cell Linker (BLNK) Antibodies

BLNK encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development.

list all antibodies Gene Name GeneID UniProt
Anti-Mouse BLNK BLNK 17060 Q9QUN3
Anti-Human BLNK BLNK 29760 Q8WV28
Anti-Rat BLNK BLNK 499356 Q4KM52
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Top anti-B-Cell Linker Antibodies at antibodies-online.com

Showing 10 out of 223 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-BLNK Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  NCI-H226 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of BLNK (arrow) using rabbit polyclonal BLNK Antibody (N-term) (ABIN657356). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the BLNK gene. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Goat Un-conjugated ELISA, WB ABIN184602 staining (4µg/ml) of Daudi lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. 100 μg Log in to see 6 to 7 Days
$358.02
Details
Human Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of BLNK staining in human liver cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of BLNK expression in Raji (A), LOVO (B) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from K562 cells treated with starved 24h, using BLNK (Phospho-Tyr84) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain, using BLNK (Phospho-Tyr84) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Mouse Un-conjugated ELISA, FACS, IF, IHC, IHC (p), WB 100 μL Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from LOVO cells, treated with etoposide 25uM 24h, using BLNK (Ab-96) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human tonsil tissue, using BLNK (Ab-96) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from COLO205 cells, using BLNK (Phospho-Tyr96) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human lymph node, using BLNK (Phospho-Tyr96) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Mouse Un-conjugated ICC, FACS, IHC, ELISA, WB Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 ng), Blue: Antigen (100 ng) Figure 2: Flow cytometric analysis of NIH/3T3 cells using BLNK mouse mAb (green) and negative control (purple) . 100 μL Log in to see 2 to 3 Days
$430.10
Details
Cow Goat Un-conjugated EIA, WB   0.1 mg Log in to see 8 to 11 Days
$462.00
Details

Top referenced anti-B-Cell Linker Antibodies

  1. Human Monoclonal BLNK Primary Antibody for ICS - ABIN1176912 : Li, Martin, Oliver, Kearney, Carter: Antigen receptor proximal signaling in splenic B-2 cell subsets. in Journal of immunology (Baltimore, Md. : 1950) 2001 (PubMed)
    Show all 4 Pubmed References

  2. Human Monoclonal BLNK Primary Antibody for ICC, FACS - ABIN968984 : Imamura, Oda, Katahira, Bundo, Pike, Ratcliffe, Kitamura: BLNK binds active H-Ras to promote B cell receptor-mediated capping and ERK activation. in The Journal of biological chemistry 2009 (PubMed)
    Show all 2 Pubmed References

  3. Human Monoclonal BLNK Primary Antibody for ICS - ABIN1177037 : Espeli, Mancini, Breton, Poirier, Schiff: Impaired B-cell development at the pre-BII-cell stage in galectin-1-deficient mice due to inefficient pre-BII/stromal cell interactions. in Blood 2009 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal BLNK Primary Antibody for IF (p), IHC (p) - ABIN750038 : Luger, Yang, Raviv, Weinberg, Banerjee, Lee, Trepel, Yang, Wakefield: Expression of the B-cell receptor component CD79a on immature myeloid cells contributes to their tumor promoting effects. in PLoS ONE 2013 (PubMed)

  5. Human Polyclonal BLNK Primary Antibody for ELISA, WB - ABIN256934 : Fu, Turck, Kurosaki, Chan: BLNK: a central linker protein in B cell activation. in Immunity 1998 (PubMed)

  6. Mouse (Murine) Polyclonal BLNK Primary Antibody for WB - ABIN2477663 : Lane, Grodner, Graves: Irradiation studies of mallard duck eggs material containing Mirex. in Journal of agricultural and food chemistry 1976 (PubMed)
    Show all 3 Pubmed References

More Antibodies against B-Cell Linker Interaction Partners

Mouse (Murine) B-Cell Linker (BLNK) interaction partners

  1. The pre-B-cell receptor (pre-BCR (show BCR Antibodies)) signaling molecules BLNK, BTK (show BTK Antibodies) and BANK1 (show BANK1 Antibodies) were positively regulated by the ZFP521 (show ZNF521 Antibodies) gene, leading to enhancement of the pre-BCR (show BCR Antibodies) signaling pathway.

  2. Authors demonstrate leukemogenicity of PAX5 (show PAX5 Antibodies)-PML (show PML Antibodies) by introducing it into normal mouse pro-B cells; B-cell linker protein (Blnk) is repressed by PAX5 (show PAX5 Antibodies)-PML (show PML Antibodies) in leukemia cells; enforced expression of Blnk increases survival despite introduction of PAX5 (show PAX5 Antibodies)-PML (show PML Antibodies).

  3. B-cell linker protein expression contributes to controlling allergic and autoimmune diseases by mediating IL-10 (show IL10 Antibodies) production in regulatory B cells.

  4. Tumor suppressor BLNK is a target of transcriptional activation by PU.1 and Spi-B (show SPIB Antibodies) in the B cell lineage.

  5. a novel negative feedback regulation of BCR (show BCR Antibodies) signaling by HPK1 (show MAP4K1 Antibodies)-mediated phosphorylation, ubiquitination, and subsequent degradation of the activated BLNK

  6. CMTM7 (show CMTM7 Antibodies) functions to link sIgM and BLNK in the plasma membrane.

  7. Live cell imaging and co-immunoprecipitation experiments confirmed that both SLP65 and CIN85 (show SH3KBP1 Antibodies) are both required for the onset and progression phases of B-cell antigen receptor signal transduction.

  8. malignant transformation of Btk (show BTK Antibodies)/Slp65 double-deficient pre-B cells is independent of deregulated V(D)J recombination activity.

  9. Swip-1 (show WSB1 Antibodies) provides a membrane scaffold that is required for the Syk (show SYK Antibodies)-, SLP-65-, and PLCgamma2 (show PLCG2 Antibodies)-dependent BCR (show BCR Antibodies)-induced calcium flux.

  10. malignant transformation of Slp65(-/-) pre-B cells involves disruption of the p19(Arf)-Mdm2-p53 tumor suppressor pathway

Human B-Cell Linker (BLNK) interaction partners

  1. vesicular signaling scaffolds are required for B cell activation indicates that vesicles may deliver preassembled signaling cargo to sites of BCR (show BCR Antibodies) activation.

  2. early Ca(2 (show CA2 Antibodies)+) fluxing provides feed-forward signal amplification by promoting anchoring of the PLCgamma2 (show PLCG2 Antibodies) C2 domain to phospho-SLP65.

  3. up-regulation of BLNK is associated with RUNX1 (show RUNX1 Antibodies) mutations in cytogenetically normal acute myeloid leukemia (show BCL11A Antibodies).

  4. Live cell imaging and co-immunoprecipitation experiments confirmed that both SLP65 and CIN85 (show SH3KBP1 Antibodies) are both required for the onset and progression phases of B-cell antigen receptor signal transduction.

  5. 16 of the 34 childhood pre-B acute lymphoblastic leukaemia samples that were tested showed a complete loss or drastic reduction of SLP-65 expression

  6. The BLNK protein is present in the majority of mediastinal B cell lymphomas.

  7. In B cells SLP-65 exists in a 180 kDa complex as well as in monomeric form.

  8. V(H) gene rearrangement represents a frequent feature in B-lymphoid malignancy, which can be attributed to SLP65 deficiency in many cases.

  9. Syk (show SYK Antibodies) is required to link phosphorylated SLP-65 to Ca(2 (show CA2 Antibodies)+) mobilization.

  10. Plasmacytoid dendritic cells express a signalosome consisting of Lyn (show LYN Antibodies), Syk (show SYK Antibodies), Btk (show BTK Antibodies), Slp65 (Blnk) and PLCgamma2 (show PLCG2 Antibodies). Triggering CD303 leads to tyrosine phosphorylation of Syk (show SYK Antibodies), Slp65, PLCgamma2 (show PLCG2 Antibodies) & cytoskeletal proteins.

B-Cell Linker (BLNK) Antigen Profile

Protein Summary

This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with anti-B-Cell Linker (BLNK) Antibodies

  • B-cell linker (BLNK) antibody
  • B-cell linker (blnk) antibody
  • B cell linker (Blnk) antibody
  • B-cell linker (Blnk) antibody
  • AGM4 antibody
  • BASH antibody
  • bca antibody
  • blnk antibody
  • BLNK-S antibody
  • Ly-57 antibody
  • LY57 antibody
  • Lyw-57 antibody
  • MGC147045 antibody
  • SLP-65 antibody
  • SLP65 antibody

Protein level used designations for anti-B-Cell Linker (BLNK) Antibodies

B-cell linker , B-cell linker protein , b-cell linker protein-like , B-cell adapter containing a SH2 domain protein , B-cell adapter containing a Src homology 2 domain protein , cytoplasmic adapter protein , lymphocyte antigen 57 , src homology 2 domain-containing leukocyte protein of 65 kDa , B cell adaptor containing SH2 domain , B cell linker protein , B-cell activation , Src homology 2 domain-containing leukocyte protein of 65 kDa , Src homology [SH2] domain-containing leukocyte protein of 65 kD , B cell linker protein BLNK , B-cell adapter SH2 domain-containing protein , SLP-65

GENE ID SPECIES
100070841 Equus caballus
405764 Danio rerio
450641 Pan troglodytes
548350 Xenopus (Silurana) tropicalis
704363 Macaca mulatta
100306798 Salmo salar
100456635 Pongo abelii
100481331 Ailuropoda melanoleuca
100593492 Nomascus leucogenys
17060 Mus musculus
29760 Homo sapiens
395733 Gallus gallus
499356 Rattus norvegicus
486814 Canis lupus familiaris
100152350 Sus scrofa
510393 Bos taurus
100712978 Cavia porcellus
101111241 Ovis aries
100354716 Oryctolagus cuniculus
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