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BLNK encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. Additionally we are shipping B-Cell Linker Kits (27) and B-Cell Linker Proteins (13) and many more products for this protein.
Showing 10 out of 212 products:
Human Monoclonal BLNK Primary Antibody for WB - ABIN967596
Chiu, Dalton, Ishiai, Kurosaki, Chan: BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins. in The EMBO journal 2002
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Human Monoclonal BLNK Primary Antibody for ICS - ABIN1176912
Li, Martin, Oliver, Kearney, Carter: Antigen receptor proximal signaling in splenic B-2 cell subsets. in Journal of immunology (Baltimore, Md. : 1950) 2001
Show all 4 Pubmed References
Human Monoclonal BLNK Primary Antibody for ICC, FACS - ABIN968984
Imamura, Oda, Katahira, Bundo, Pike, Ratcliffe, Kitamura: BLNK binds active H-Ras to promote B cell receptor-mediated capping and ERK activation. in The Journal of biological chemistry 2009
Show all 2 Pubmed References
Human Monoclonal BLNK Primary Antibody for ICS - ABIN1177037
Espeli, Mancini, Breton, Poirier, Schiff: Impaired B-cell development at the pre-BII-cell stage in galectin-1-deficient mice due to inefficient pre-BII/stromal cell interactions. in Blood 2009
Show all 2 Pubmed References
Human Monoclonal BLNK Primary Antibody for ICS, WB - ABIN967656
Taguchi, Kiyokawa, Takenouch, Matsui, Tang, Nakajima, Suzuki, Shiozawa, Saito, Katagiri, Takahashi, Karasuyama, Matsuo, Okita, Fujimoto: Deficiency of BLNK hampers PLC-gamma2 phosphorylation and Ca2+ influx induced by the pre-B-cell receptor in human pre-B cells. in Immunology 2004
Human Polyclonal BLNK Primary Antibody for IF (p), IHC (p) - ABIN750038
Luger, Yang, Raviv, Weinberg, Banerjee, Lee, Trepel, Yang, Wakefield: Expression of the B-cell receptor component CD79a on immature myeloid cells contributes to their tumor promoting effects. in PLoS ONE 2013
The pre-B-cell receptor (pre-BCR (show BCR Antibodies)) signaling molecules BLNK, BTK (show BTK Antibodies) and BANK1 (show BANK1 Antibodies) were positively regulated by the ZFP521 (show ZNF521 Antibodies) gene, leading to enhancement of the pre-BCR (show BCR Antibodies) signaling pathway.
Authors demonstrate leukemogenicity of PAX5 (show PAX5 Antibodies)-PML (show PML Antibodies) by introducing it into normal mouse pro-B cells; B-cell linker protein (Blnk) is repressed by PAX5 (show PAX5 Antibodies)-PML (show PML Antibodies) in leukemia cells; enforced expression of Blnk increases survival despite introduction of PAX5 (show PAX5 Antibodies)-PML (show PML Antibodies).
B-cell linker protein expression contributes to controlling allergic and autoimmune diseases by mediating IL-10 (show IL10 Antibodies) production in regulatory B cells.
Tumor suppressor BLNK is a target of transcriptional activation by PU.1 and Spi-B (show SPIB Antibodies) in the B cell lineage.
a novel negative feedback regulation of BCR (show BCR Antibodies) signaling by HPK1 (show MAP4K1 Antibodies)-mediated phosphorylation, ubiquitination, and subsequent degradation of the activated BLNK
CMTM7 (show CMTM7 Antibodies) functions to link sIgM and BLNK in the plasma membrane.
Live cell imaging and co-immunoprecipitation experiments confirmed that both SLP65 and CIN85 (show SH3KBP1 Antibodies) are both required for the onset and progression phases of B-cell antigen receptor signal transduction.
malignant transformation of Btk (show BTK Antibodies)/Slp65 double-deficient pre-B cells is independent of deregulated V(D)J recombination activity.
Swip-1 (show WSB1 Antibodies) provides a membrane scaffold that is required for the Syk (show SYK Antibodies)-, SLP-65-, and PLCgamma2 (show PLCG2 Antibodies)-dependent BCR (show BCR Antibodies)-induced calcium flux.
malignant transformation of Slp65(-/-) pre-B cells involves disruption of the p19(Arf)-Mdm2-p53 tumor suppressor pathway
vesicular signaling scaffolds are required for B cell activation indicates that vesicles may deliver preassembled signaling cargo to sites of BCR (show BCR Antibodies) activation.
early Ca(2 (show CA2 Antibodies)+) fluxing provides feed-forward signal amplification by promoting anchoring of the PLCgamma2 (show PLCG2 Antibodies) C2 domain to phospho-SLP65.
up-regulation of BLNK is associated with RUNX1 (show RUNX1 Antibodies) mutations in cytogenetically normal acute myeloid leukemia (show BCL11A Antibodies).
16 of the 34 childhood pre-B acute lymphoblastic leukaemia samples that were tested showed a complete loss or drastic reduction of SLP-65 expression
The BLNK protein is present in the majority of mediastinal B cell lymphomas.
In B cells SLP-65 exists in a 180 kDa complex as well as in monomeric form.
V(H) gene rearrangement represents a frequent feature in B-lymphoid malignancy, which can be attributed to SLP65 deficiency in many cases.
Syk (show SYK Antibodies) is required to link phosphorylated SLP-65 to Ca(2 (show CA2 Antibodies)+) mobilization.
Plasmacytoid dendritic cells express a signalosome consisting of Lyn (show LYN Antibodies), Syk (show SYK Antibodies), Btk (show BTK Antibodies), Slp65 (Blnk) and PLCgamma2 (show PLCG2 Antibodies). Triggering CD303 leads to tyrosine phosphorylation of Syk (show SYK Antibodies), Slp65, PLCgamma2 (show PLCG2 Antibodies) & cytoskeletal proteins.
This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene.
, B-cell linker protein
, b-cell linker protein-like
, B-cell adapter containing a SH2 domain protein
, B-cell adapter containing a Src homology 2 domain protein
, cytoplasmic adapter protein
, lymphocyte antigen 57
, src homology 2 domain-containing leukocyte protein of 65 kDa
, B cell adaptor containing SH2 domain
, B cell linker protein
, B-cell activation
, Src homology 2 domain-containing leukocyte protein of 65 kDa
, Src homology [SH2] domain-containing leukocyte protein of 65 kD
, B cell linker protein BLNK
, B-cell adapter SH2 domain-containing protein