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B-Cell Linker Products

(B-Cell Linker (BLNK))

Categories

This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012].

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Featured B-Cell Linker Categories

B-Cell Linker Antibodies

High quality antibodies with extensive validation data.

B-Cell Linker ELISA Kits

Reliable ELISA kits for a wide range of species.

B-Cell Linker Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended B-Cell Linker Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Application WB, ELISA, IHC, FACS, ICC
Validations
  • (2)
  • (6)
Cat. No. ABIN968984
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, ICC, IP
Validations
  • (6)
Cat. No. ABIN7441781
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, FACS, IF
Validations
  • (4)
Cat. No. ABIN184602
Quantity 100 μg
Datasheet Datasheet

Recommended B-Cell Linker ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN1380291
Quantity 2 x 96 tests
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN1380804
Quantity 2 x 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Competition ELISA
Validations
Cat. No. ABIN511244
Quantity 96 tests
Datasheet Datasheet

Recommended B-Cell Linker Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1346721
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1346719
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7121966
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our B-Cell Linker products

Luger, Yang, Raviv, Weinberg, Banerjee, Lee, Trepel, Yang, Wakefield: "Expression of the B-cell receptor component CD79a on immature myeloid cells contributes to their tumor promoting effects." in: PLoS ONE, Vol. 8, Issue 10, pp. e76115, (2013) (PubMed).

Pighi, Gu, Dalai, Barbi, Parolini, Bertolaso, Pedron, Parisi, Ren, Cecconi, Chilosi, Menestrina, Zamò: "Phospho-proteomic analysis of mantle cell lymphoma cells suggests a pro-survival role of B-cell receptor signaling." in: Cellular oncology (Dordrecht), Vol. 34, Issue 2, pp. 141-53, (2011) (PubMed).

Imamura, Oda, Katahira, Bundo, Pike, Ratcliffe, Kitamura: "BLNK binds active H-Ras to promote B cell receptor-mediated capping and ERK activation." in: The Journal of biological chemistry, Vol. 284, Issue 15, pp. 9804-13, (2009) (PubMed).

Espeli, Mancini, Breton, Poirier, Schiff: "Impaired B-cell development at the pre-BII-cell stage in galectin-1-deficient mice due to inefficient pre-BII/stromal cell interactions." in: Blood, Vol. 113, Issue 23, pp. 5878-86, (2009) (PubMed).

Kamino, Futamura, Nakamura, Kitamura, Kabu, Arakawa: "B-cell linker protein prevents aneuploidy by inhibiting cytokinesis." in: Cancer science, Vol. 99, Issue 12, pp. 2444-54, (2008) (PubMed).

Koretzky, Abtahian, Silverman: "SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond." in: Nature reviews. Immunology, Vol. 6, Issue 1, pp. 67-78, (2006) (PubMed).

Wu, Koretzky: "The SLP-76 family of adapter proteins." in: Seminars in immunology, Vol. 16, Issue 6, pp. 379-93, (2004) (PubMed).

Taguchi, Kiyokawa, Takenouch, Matsui, Tang, Nakajima, Suzuki, Shiozawa, Saito, Katagiri, Takahashi, Karasuyama, Matsuo, Okita, Fujimoto: "Deficiency of BLNK hampers PLC-gamma2 phosphorylation and Ca2+ influx induced by the pre-B-cell receptor in human pre-B cells." in: Immunology, Vol. 112, Issue 4, pp. 575-82, (2004) (PubMed).

Janssen, Zhang: "Adaptor proteins in lymphocyte activation." in: Current opinion in immunology, Vol. 15, Issue 3, pp. 269-76, (2003) (PubMed).

Kersseboom, Middendorp, Dingjan, Dahlenborg, Reth, Jumaa, Hendriks: "Bruton's tyrosine kinase cooperates with the B cell linker protein SLP-65 as a tumor suppressor in Pre-B cells." in: The Journal of experimental medicine, Vol. 198, Issue 1, pp. 91-8, (2003) (PubMed).

Synonyms and alternative names related to B-Cell Linker

B-cell linker (BLNK), B-cell linker (blnk), B cell linker (Blnk), B-cell linker (Blnk), AGM4, BASH, Bca, bca, BLNK, blnk, BLNK-S, Ly-57, Ly57, LY57, Lyw-57, MGC147045, SLP-65, SLP65

Protein level used designations for B-Cell Linker

  • B-cell linker
  • B-cell linker protein
  • b-cell linker protein-like
  • B-cell adapter containing a SH2 domain protein
  • B-cell adapter containing a Src homology 2 domain protein
  • cytoplasmic adapter protein
  • lymphocyte antigen 57
  • src homology 2 domain-containing leukocyte protein of 65 kDa
  • B cell adaptor containing SH2 domain
  • B cell linker protein
  • B-cell activation
  • Src homology 2 domain-containing leukocyte protein of 65 kDa
  • Src homology [SH2] domain-containing leukocyte protein of 65 kD
  • B cell linker protein BLNK
  • B-cell adapter SH2 domain-containing protein
  • SLP-65
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