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The protein encoded by BCOR was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. Additionally we are shipping BCOR Proteins (7) and BCOR Kits (4) and many more products for this protein.
Showing 10 out of 69 products:
Human Polyclonal BCOR Primary Antibody for ELISA, WB - ABIN565785
Sánchez, Sánchez, Demmers, Rodriguez, Strouboulis, Vidal: Proteomics analysis of Ring1B/Rnf2 interactors identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6 interacting corepressor. in Molecular & cellular proteomics : MCP 2007
Cow (Bovine) Polyclonal BCOR Primary Antibody for ChIP, ELISA - ABIN249965
Tang, Dowbenko, Jackson, Toney, Lewin, Dent, Lasky: The forkhead transcription factor AFX activates apoptosis by induction of the BCL-6 transcriptional repressor. in The Journal of biological chemistry 2002
Human Polyclonal BCOR Primary Antibody for IP, WB - ABIN4283798
Dietrich, Lerdrup, Landt, Agrawal-Singh, Bak, Tommerup, Rappsilber, Södersten, Hansen: REST-mediated recruitment of polycomb repressor complexes in mammalian cells. in PLoS genetics 2012
Human Polyclonal BCOR Primary Antibody for ChIP, ELISA - ABIN185043
Huet, Fanget, Jouannot, Meireles, Zeiske, Larochette, Darchen, Desnos: Myrip couples the capture of secretory granules by the actin-rich cell cortex and their attachment to the plasma membrane. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2012
Show all 2 Pubmed References
BCOR-ITD was positively detected in the cfDNA of two cases, both of which were later diagnosed as CCSK based on histological feature of the resected tumor specimen, while it was not detected for a normal control and a patient diagnosed with Wilms' tumor.
Multivariate analysis demonstrated that BCOR mutations were an independent unfavorable prognostic factor (P = 0.0038, P = 0.0463) for both OS and RFS.
BCOR mutation is associated with tooth agenesis.
The majority of the cases of clear cell sarcoma of the kidney in our cohort had BCOR internal tandem duplications
BCOR was negative in all ewing sarcoma family of tumors
BCOR immunohistochemical staining is a highly sensitive marker for YWHAE (show YWHAE Antibodies)-NUTM2 high-grade endometrial stromal sarcoma with both classic and unusual morphology and identifies a subset of high-grade endometrial stromal sarcoma with BCOR alterations, including BCOR rearrangement and internal tandem duplication.
the frequent BCOR mutations and the absence of alterations in genes regulating the NF-kappaB (show NFKB1 Antibodies) pathway (triple-negative for KLF2 (show KLF2 Antibodies), TNFAIP3 (show TNFAIP3 Antibodies) and MYD88 (show MYD88 Antibodies) mutations) or the absence of a BRAF (show BRAF Antibodies) mutation appear to delineate a specific genetic pattern of SDRPL, which is distinct from that already identified in SMZL, HCL or HCL-v.
BCOR internal tandem duplication and/or nuclear immunoreactivity for BCOR or BCL6 (show BCL6 Antibodies) can aid in the diagnosis of primitive myxoid mesenchymal tumor of infancy and help to differentiate it from congenital infantile fibrosarcoma.
Case Report: altered BCOR expression and homogeneous coactivation of both the SHH (show SHH Antibodies) and WNT (show WNT2 Antibodies) signaling pathways, and suggest potential novel therapeutic approaches for patients with a high grade neuroepithelial tumor of the central nervous system with BCOR alteration diagnosis.
Immunohistochemistry for either CCNB3 (show CCNB3 Antibodies) or BCOR is not completely sensitive and specific in undifferentiated sarcoma with BCOR-CCNB3 (show CCNB3 Antibodies) fusion.
Genomic characterization of Emu-Myc (show MYC Antibodies) mouse lymphomas identifies Bcor as a Myc (show MYC Antibodies) cooperative tumor-suppressor gene.
results provide the first evidence of a tumor suppressor role for BCOR in the pathogenesis of T lymphocyte malignancies
Data show that BCL6 interacting corepressor Bcor Is Specifically Down-regulated by Activin (show Actbeta Antibodies) Signaling in trophoblast stem cells (TSCs).
T cell-expressed BCOR is critical for optimal GC-Tfh cell differentiation and humoral immunity.
IRF8 (show IRF8 Antibodies) pairs with BCL6 co-repressor BCOR in the nucleus to enhance its transcriptional repressive activity.
Results suggest that Bcor expressed in the mesenchyme plays crucial roles during early tooth development.
Study isolated an Fbxl10/Jhdm1B (show KDM2B Antibodies) complex by Study using a high throughput proteomics approach identified interactors with Rnf2 (show RNF2 Antibodies) including Fbxl10/Jhdm1B (show KDM2B Antibodies), casein kinase subunits, and the BcoR corepressor
Bcor plays a role in differentiation of multiple tissue lineages during early embryonic development.
The protein encoded by this gene was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link between the two classes of HDACs. Several transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome Y.
, BCL-6 interacting corepressor
, BCL6 co-repressor
, Bcl6 interacting corepressor