anti-BCL6 Co-Repressor (BCOR) Antibodies

The protein encoded by BCOR was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. Additionally we are shipping BCOR Proteins (7) and BCOR Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
BCOR 54880 Q6W2J9
BCOR 317346  
BCOR 71458 Q8CGN4
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Top anti-BCOR Antibodies at antibodies-online.com

Showing 10 out of 76 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Goat Un-conjugated ChIP, ELISA   100 μg 6 to 7 Days
$429.84
Details
Human Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of BCOR staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of BCOR expression in HEK293T (A) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, IHC, WB ABIN6274592 staining COLO205 by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody. ABIN6274592 at 1/100 staining Mouse colon tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from COLO cells, using BCOR Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using BCOR Antibody. The picture on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, IHC, WB 100 μL Available
$363.46
Details
Human Rabbit Un-conjugated ELISA, IHC, IHC (p), WB 100 μL 11 to 14 Days
$493.17
Details
Human Rabbit Un-conjugated IHC, IHC (p), IP Anti-BCOR antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml. 50 μL 11 to 14 Days
$639.83
Details
Bat Goat Un-conjugated ELISA   100 μg 11 to 14 Days
$610.50
Details
Human Rabbit Un-conjugated IF, IF/ICC Immunofluorescence staining of BCOR in HeLa cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS,blocked with 10% serum, and incubated with rabbit anti-human BCOR polyclonal antibody (1 µg/ml) at 4℃ overnight. Then cells were stained with the Alexa Fluor®594-conjugated Goat Anti-rabbit IgG secondary antibody (red)Positive staining was localized to nucleus. 100 μL 14 to 16 Days
$247.82
Details
Human Mouse Un-conjugated IF, WB Western Blot analysis of BCOR expression in transfected 293T cell line by BCOR MaxPab polyclonal antibody.Lane 1: BCOR transfected lysate(110.44 KDa).Lane 2: Non-transfected lysate. BCOR MaxPab polyclonal antibody. Western Blot analysis of BCOR expression in human colon. 50 μL 11 to 12 Days
$440.00
Details

Top referenced anti-BCOR Antibodies

  1. Human Polyclonal BCOR Primary Antibody for ChIP, ELISA - ABIN185043 : Tang, Dowbenko, Jackson, Toney, Lewin, Dent, Lasky: The forkhead transcription factor AFX activates apoptosis by induction of the BCL-6 transcriptional repressor. in The Journal of biological chemistry 2002 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal BCOR Primary Antibody for ELISA, WB - ABIN565785 : Sánchez, Sánchez, Demmers, Rodriguez, Strouboulis, Vidal: Proteomics analysis of Ring1B/Rnf2 interactors identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6 interacting corepressor. in Molecular & cellular proteomics : MCP 2007 (PubMed)

  3. Human Polyclonal BCOR Primary Antibody for IP, WB - ABIN4283798 : Dietrich, Lerdrup, Landt, Agrawal-Singh, Bak, Tommerup, Rappsilber, Södersten, Hansen: REST-mediated recruitment of polycomb repressor complexes in mammalian cells. in PLoS genetics 2012 (PubMed)

More Antibodies against BCOR Interaction Partners

Human BCL6 Co-Repressor (BCOR) interaction partners

  1. BCOR rearranged high grade endometrial stromal sarcoma has distinct morphological features and aggressive clinical behavior

  2. A new term of X-linked BCOR-related syndrome.

  3. Letter: diffuse strong nuclear labeling for BCOR occurs in pediatric clear cell sarcoma of the kidney.

  4. Detection of fusion transcripts BCOR-CCNB3 in the bone marrow suggests that undifferentiated sarcoma patients with positive findings are at high risk of tumor progression.

  5. The C terminus of BCOR regulates the assembly and targeting of the PRC1.1 complex, while the N terminus contributes to BCOR-PRC1.1 repressor function.

  6. co-expression of KPNA2, KPNA4, or KPNA6 with BCOR carrying a previously described mutation which eliminated one of the two nuclear localization signals significantly increased nuclear accumulation of the mutant BCOR.

  7. Report a series of BCOR-CCNB3 fusion sarcomas, highlighting the significant morphologic, immunohistochemical and transcriptional overlap with other primitive round/spindle cell sarcomas.

  8. Suggest that uterine neoplasms with BCOR internal tandem duplication be regarded as a unique subtype of high-grade uterine sarcoma, possibly within the family of endometrial stromal neoplasia.

  9. BCOR-ITDs define a rare subset of pediatric sarcomas and clinically aggressive endometrial stromal sarcoma cases, as defined by NGS for the first time.

  10. BCOR-ITD was positively detected in the cfDNA of two cases, both of which were later diagnosed as CCSK based on histological feature of the resected tumor specimen, while it was not detected for a normal control and a patient diagnosed with Wilms' tumor.

  11. Multivariate analysis demonstrated that BCOR mutations were an independent unfavorable prognostic factor (P = 0.0038, P = 0.0463) for both OS and RFS.

  12. BCOR mutation is associated with tooth agenesis.

  13. The majority of the cases of clear cell sarcoma of the kidney in our cohort had BCOR internal tandem duplications

  14. BCOR was negative in all ewing sarcoma family of tumors

  15. BCOR immunohistochemical staining is a highly sensitive marker for YWHAE-NUTM2 high-grade endometrial stromal sarcoma with both classic and unusual morphology and identifies a subset of high-grade endometrial stromal sarcoma with BCOR alterations, including BCOR rearrangement and internal tandem duplication.

  16. the frequent BCOR mutations and the absence of alterations in genes regulating the NF-kappaB pathway (triple-negative for KLF2, TNFAIP3 and MYD88 mutations) or the absence of a BRAF mutation appear to delineate a specific genetic pattern of SDRPL, which is distinct from that already identified in SMZL, HCL or HCL-v.

  17. BCOR internal tandem duplication and/or nuclear immunoreactivity for BCOR or BCL6 can aid in the diagnosis of primitive myxoid mesenchymal tumor of infancy and help to differentiate it from congenital infantile fibrosarcoma.

  18. Case Report: altered BCOR expression and homogeneous coactivation of both the SHH and WNT signaling pathways, and suggest potential novel therapeutic approaches for patients with a high grade neuroepithelial tumor of the central nervous system with BCOR alteration diagnosis.

  19. Immunohistochemistry for either CCNB3 or BCOR is not completely sensitive and specific in undifferentiated sarcoma with BCOR-CCNB3 fusion.

  20. Case Reports: renal sarcomas with BCOR-CCNB3 gene fusion showing histological overlap with BCOR-related clear cell sarcoma of the kidney.

Mouse (Murine) BCL6 Co-Repressor (BCOR) interaction partners

  1. results reveal a tumor suppressor function of BCOR in myeloid malignancies and highlight the impact of Bcor insufficiency on the initiation and progression of MDS.

  2. This study provides mechanistic understanding of how BCOR regulates cell fate decisions and how loss of function contributes to the development of leukaemia.

  3. Genomic characterization of Emu-Myc mouse lymphomas identifies Bcor as a Myc cooperative tumor-suppressor gene.

  4. results provide the first evidence of a tumor suppressor role for BCOR in the pathogenesis of T lymphocyte malignancies

  5. Data show that BCL6 interacting corepressor Bcor Is Specifically Down-regulated by Activin Signaling in trophoblast stem cells (TSCs).

  6. T cell-expressed BCOR is critical for optimal GC-Tfh cell differentiation and humoral immunity.

  7. IRF8 pairs with BCL6 co-repressor BCOR in the nucleus to enhance its transcriptional repressive activity.

  8. Results suggest that Bcor expressed in the mesenchyme plays crucial roles during early tooth development.

  9. Study isolated an Fbxl10/Jhdm1B complex by Study using a high throughput proteomics approach identified interactors with Rnf2 including Fbxl10/Jhdm1B, casein kinase subunits, and the BcoR corepressor

  10. Bcor plays a role in differentiation of multiple tissue lineages during early embryonic development.

BCOR Antigen Profile

Protein Summary

The protein encoded by this gene was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link between the two classes of HDACs. Several transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome Y.

Gene names and symbols associated with BCOR

  • BCL6 corepressor (BCOR) antibody
  • BCL6 corepressor (bcor) antibody
  • BCL6 co-repressor (Bcor) antibody
  • BCL6 interacting corepressor (Bcor) antibody
  • 5830466J11Rik antibody
  • 8430401K06Rik antibody
  • ANOP2 antibody
  • BCOR antibody
  • BcorR antibody
  • D930024N20Rik antibody
  • MAA2 antibody
  • MCOPS2 antibody
  • mKIAA1575 antibody
  • RGD1562735 antibody

Protein level used designations for BCOR

BCL-6 corepressor , BCL-6 interacting corepressor , BCL6 co-repressor , Bcl6 interacting corepressor

GENE ID SPECIES
54880 Homo sapiens
100050335 Equus caballus
698644 Macaca mulatta
784529 Bos taurus
402921 Danio rerio
418574 Gallus gallus
317346 Rattus norvegicus
480880 Canis lupus familiaris
465574 Pan troglodytes
71458 Mus musculus
100154380 Sus scrofa
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