anti-Baculoviral IAP Repeat-Containing 6 (BIRC6) Antibodies

Human Baculoviral IAP Repeat-Containing 6 (BIRC6) interaction partners

1. Data indicate BRUCE/Apollon/Birc6, an inhibitor of apoptosis protein (IAP (show BIRC2 Antibodies)), as a new autophagy regulator.

2. Since specific expression of BRUCE protein was revealed in majority of gastric carcinoma tissues, BRUCE protein may be a useful therapeutic target for cancer therapy.

3. BIRC6 targeting inhibited the growth of enzalutamide-resistant castration-resistant prostate cancer models and may represent a new option for clinical treatment of advanced, enzalutamide-resistant prostate cancer

4. AVEN (show AVEN Antibodies) and BIRC6 are inhibited by combination therapy of miR (show MLXIP Antibodies)-30e and proanthocyanidin in glioblastoma stem cells

5. Apollon expression is associated with the biological characteristics of esophageal squamous cell carcinoma (ESCC), and may be a valuable prognostic factor and a novel chemotherapeutic target for ESCC treatment.

6. Apollon role in the multidrug resistance of human chronic myelogenous leukemia cells

7. Apollon gene silencing can induce apoptosis and growth impairment in HeLa cells. In this regard, apollon can be considered a candidate therapeutic target in HeLa cells as a positive human papillomavirus cancer cell line.

8. BRUCE protein was detected in 82% of tumors and tumor progression stage and invasion depth correlated significantly with BRUCE protein expression

9. Results show that in addition to the scaffolding function in complex formation, BRUCE has an E3 ligase function to promote BRIT1 (show MCPH1 Antibodies) deubiquitination by USP8 (show USP8 Antibodies) leading to accumulation of BRIT1 (show MCPH1 Antibodies) at DNA double-strand break.

10. BIRC6 overexpression is a predictor of poor prognosis in colorectal cancer and could be a potential target for colorectal cancer therapy.

Cow (Bovine) Baculoviral IAP Repeat-Containing 6 (BIRC6) interaction partners

1. The results of this study reveal the importance of BIRC6 expression for embryo survival during bovine preimplantation embryo development.

Mouse (Murine) Baculoviral IAP Repeat-Containing 6 (BIRC6) interaction partners

1. Data indicate BRUCE/Apollon/Birc6, an inhibitor of apoptosis protein (IAP (show BIRC2 Antibodies)), as a new autophagy regulator.

2. Humanin signaling pathway via htHNR/JAKs/STAT3 (show STAT3 Antibodies) increased the expression levels of mRNA and protein of Apollon/Bruce, an unusual member of the inhibitors of apoptosis proteins

3. BRUCE acts as a scaffold, bridging the ubiquitin-specific peptidase 8 (USP8 (show USP8 Antibodies)) and BRIT1 (show MCPH1 Antibodies) in a complex to coordinate USP8 (show USP8 Antibodies)-catalyzed deubiquitination of BRIT1 (show MCPH1 Antibodies).

4. BRUCE protects cells against apoptosis and functions as an inhibitor of apoptosis.

5. BRUCE is broadly expressed in embryonic, extraembryonic, and adult mouse tissues, this bifunctional protein might play a unique role in normal trophoblast differentiation and embryonic survival

6. p53 (show TP53 Antibodies) is a downstream effector of Bruce, and, in response to loss of Bruce function, p53 (show TP53 Antibodies) activates Pidd (show PIDD Antibodies)/caspase-2 (show CASP2 Antibodies) and Bax (show BAX Antibodies)/Bak (show BAK1 Antibodies), leading to mitochondrial apoptosis

7. Birc6 plays a role in cell division

8. These results establish a previously unrecognized link between NFAT (show NFATC1 Antibodies) signaling and regulation of IAP (show ALPI Antibodies) expression and are the first to identify a signaling pathway that increases BRUCE expression.