anti-Baculoviral IAP Repeat-Containing 6 (BIRC6) Antibodies

Human Baculoviral IAP Repeat-Containing 6 (BIRC6) interaction partners

1. Our study shows that BIRC6 is upregulated in prostate cancer and is associated with aggressive tumor progression. Moreover, elevated level of BIRC6 predicts poor prognosis for prostate cancer patients, and BIRC6 can regulate prostate cancer cell proliferation and apoptosis in vitro.

2. The miR-204 may play an anti-carcinogenic role in AML and function as a novel biomarker and therapeutic target for the treatment of this disease.

3. circBIRC6 and circCORO1C are functionally associated with the pluripotent state in undifferentiated human embryonic stem cells

4. Data indicate BRUCE/Apollon/Birc6, an inhibitor of apoptosis protein (IAP), as a new autophagy regulator.

5. Since specific expression of BRUCE protein was revealed in majority of gastric carcinoma tissues, BRUCE protein may be a useful therapeutic target for cancer therapy.

6. BIRC6 targeting inhibited the growth of enzalutamide-resistant castration-resistant prostate cancer models and may represent a new option for clinical treatment of advanced, enzalutamide-resistant prostate cancer

7. AVEN and BIRC6 are inhibited by combination therapy of miR-30e and proanthocyanidin in glioblastoma stem cells

8. Apollon expression is associated with the biological characteristics of esophageal squamous cell carcinoma (ESCC), and may be a valuable prognostic factor and a novel chemotherapeutic target for ESCC treatment.

9. Apollon role in the multidrug resistance of human chronic myelogenous leukemia cells

10. Apollon gene silencing can induce apoptosis and growth impairment in HeLa cells. In this regard, apollon can be considered a candidate therapeutic target in HeLa cells as a positive human papillomavirus cancer cell line.

11. BRUCE protein was detected in 82% of tumors and tumor progression stage and invasion depth correlated significantly with BRUCE protein expression

12. Results show that in addition to the scaffolding function in complex formation, BRUCE has an E3 ligase function to promote BRIT1 deubiquitination by USP8 leading to accumulation of BRIT1 at DNA double-strand break.

13. BIRC6 overexpression is a predictor of poor prognosis in colorectal cancer and could be a potential target for colorectal cancer therapy.

14. The study demonstrates that the T allele of the rs2754511 in the BIRC6 gene plays a protective role in pseudoexfoliative glaucoma patients of the Pakistani population.

15. Humanin signaling pathway via htHNR/JAKs/STAT3 increased the expression levels of mRNA and protein of Apollon/Bruce, an unusual member of the inhibitors of apoptosis proteins

16. BRUCE acts as a scaffold, bridging the ubiquitin-specific peptidase 8 (USP8) and BRIT1 in a complex to coordinate USP8-catalyzed deubiquitination of BRIT1.

17. findings demonstrate that BIRC6 overexpression in hepatocellular carcinoma specimens is indicative of poor prognosis and that its interaction with p53 facilitates the degradation of p53

18. The expression of BIRC6 in the cytoplasm is associated with epithelial ovarian cancer (EOC) differentiation and may be a novel predictor for poor prognosis of EOC patients after curative resection.

19. APPOLON to be a novel regulator of mitotic CYCLIN A degradation independent of SAC.

20. Elevated expression of BIRC6 protein in non-small-cell lung cancers is associated with cancer recurrence and chemoresistance.

Cow (Bovine) Baculoviral IAP Repeat-Containing 6 (BIRC6) interaction partners

1. The results of this study reveal the importance of BIRC6 expression for embryo survival during bovine preimplantation embryo development.

Mouse (Murine) Baculoviral IAP Repeat-Containing 6 (BIRC6) interaction partners

1. Data indicate BRUCE/Apollon/Birc6, an inhibitor of apoptosis protein (IAP), as a new autophagy regulator.

2. Humanin signaling pathway via htHNR/JAKs/STAT3 increased the expression levels of mRNA and protein of Apollon/Bruce, an unusual member of the inhibitors of apoptosis proteins

3. BRUCE acts as a scaffold, bridging the ubiquitin-specific peptidase 8 (USP8) and BRIT1 in a complex to coordinate USP8-catalyzed deubiquitination of BRIT1.

4. BRUCE protects cells against apoptosis and functions as an inhibitor of apoptosis.

5. review of role of Apollonin in mechanisms of apoptosis and cell division

6. BRUCE is broadly expressed in embryonic, extraembryonic, and adult mouse tissues, this bifunctional protein might play a unique role in normal trophoblast differentiation and embryonic survival

7. p53 is a downstream effector of Bruce, and, in response to loss of Bruce function, p53 activates Pidd/caspase-2 and Bax/Bak, leading to mitochondrial apoptosis

8. Birc6 plays a role in cell division

9. These results establish a previously unrecognized link between NFAT signaling and regulation of IAP expression and are the first to identify a signaling pathway that increases BRUCE expression.