BIRC6 antibody (C-Term)

Catalog No. ABIN6990463

This Rabbit Polyclonal antibody specifically detects BIRC6 in ELISA and IHC (p). It exhibits reactivity toward Human.

Quick Overview for BIRC6 antibody (C-Term) (ABIN6990463)

Target: BIRC6 (Baculoviral IAP Repeat-Containing 6 (BIRC6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BIRC6 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-BIRC6 Antibody

Binding Specificity: AA 4760-4810, C-Term

Specificity: BRUCE antibody is human specific. Multiple isoforms of BRUCE are known to exist.

Purification: BRUCE Antibody is affinity chromatography purified via peptide column.

Immunogen: BRUCE antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human BRUCE. The immunogen is located within amino acids 4760 - 4810 of BRUCE.

Isotype: IgG

Application Details

Application Notes: BRUCE antibody can be used for detection of BRUCE by immunohistochemistry at 5 μ,g/mL.

Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: BRUCE Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: BRUCE antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for BIRC6

Target: BIRC6 (Baculoviral IAP Repeat-Containing 6 (BIRC6))

Alternative Name: BRUCE

Background: BRUCE Antibody: Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. BRUCE, also known as BIRC6, is an IAP family member protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. BRUCE regulates p53 and the mitochondrial pathway of apoptosis by facilitating the degradation of apoptotic proteins such as Caspase-9 and SMAC by ubiquitination.

Molecular Weight: 534 kDa

Gene ID: 57448

NCBI Accession: NP_057336

UniProt: Q9NR09