anti-Bcl2 Modifying Factor (BMF) Antibodies

Human Bcl2 Modifying Factor (BMF) interaction partners

1. The findings are consistent with rs539846 influencing chronic lymphocytic leukemia (CLL) susceptibility through differential RELA (show NFkBP65 Antibodies) binding, with direct modulation of BMF expression impacting on anti-apoptotic BCL2 (show BCL2 Antibodies), a hallmark of oncogenic dependency in CLL.

2. Reciprocal regulation of BMF and BIRC5 (show BIRC5 Antibodies) is linked to Eomes (show EOMES Antibodies) overexpression in colorectal cancer.

3. Early generated B1 B cells with restricted BCRs become chronic lymphocytic leukemia with continued c-Myc (show MYC Antibodies) and low Bmf expression

4. these findings suggest that p53 (show TP53 Antibodies)-R273H can specifically drive AKT (show AKT1 Antibodies) signaling and suppress BMF expression, resulting in enhanced cell survivability and anoikis resistance.

5. On the corresponding BMF gene promoter, loss of HDAC8 (show HDAC8 Antibodies) was associated with signal transducer and activator of transcription 3 (STAT3 (show STAT3 Antibodies))/specificity protein 3 (Sp3) transcription factor exchange and recruitment of p300 (show EP300 Antibodies).

6. Overexpression of ApoL2 (show APOL2 Antibodies) did not induce cell death on its own. ApoL2 (show APOL2 Antibodies) did not sensitize or protect cells from overexpression of the BH3-only (show BBC3 Antibodies) proteins Bmf or Noxa (show PMAIP1 Antibodies).

7. Diva (show BCL2L10 Antibodies) binds peptides derived from the BH3 domain of several other proapoptotic Bcl-2 (show BCL2 Antibodies) proteins, including mouse Harakiri (show HRK Antibodies), Bid (show BID Antibodies), Bak (show BAK1 Antibodies) and Bmf.

8. BMF is induced in human IEC by the loss of cell attachment and is likely to play an important role in the regulation of IEC survival

9. characterization of the bmf gene locus; molecular basis of the generation of the 2 major isoforms of Bmf; provide evidence that Bmf can act as a sensor for stress that associates with the repression of the conventional CAP-dependent translation machinery

10. Data show that hypoxic conditions inhibit anoikis and block expression of proapoptotic BH3-only (show BBC3 Antibodies) family members Bim (show BCL2L11 Antibodies) and Bmf in epithelial cells.

Mouse (Murine) Bcl2 Modifying Factor (BMF) interaction partners

1. FOXO (show FOXO3 Antibodies)-dependent BMF expression is repressed in E-cadherin (show CDH1 Antibodies)-negative and metastatic breast cancer cells and that expression of BMFis sufficient to inhibit tumour growth and dissemination in mice.

2. BMF loss is associated with germ cell loss during oogenesis.

3. Bcl2 interacting mediator of cell death (Bim (show BCL2L11 Antibodies)) and Bcl2 modifying factor (Bmf), mediate apoptosis in the context of TACI (show TNFRSF13B Antibodies)-Ig overexpression that effectively neutralizes BAFF (show TNFSF13B Antibodies) as well as APRIL.

4. Bmf deficiency induced significant protection against oxygen/glucose deprivation injury in cultured neurons.

5. Our findings support an important role for BMF in determining the number of primordial follicles maintained in the ovary throughout adult reproductive life.

6. Bim (show BCL2L11 Antibodies) and Bmf act in concert to prevent autoimmunity and malignant disease

7. Bmf-deficient mice showed normal sensitivity to the convulsant effects of KA, displayed significantly more neuronal death in the hippocampal CA1 (show CA1 Antibodies) and CA3 (show CA3 Antibodies) subfields after SE.

8. deacetylation of p53 (show TP53 Antibodies) suppresses Bmf expression and facilitates autophagy.

9. critical role for Bim (show BCL2L11 Antibodies) and Bmf as regulators of hematopoietic stem and progenitor cell dynamics both during early engraftment and long-term reconstitution

10. our study suggests that Bad and Bmf co-regulate lymphocyte homeostasis and limit spontaneous transformation by mechanisms that may not exclusively be linked to the induction of lymphocyte apoptosis.