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BEST4 is a member of the bestrophin gene family of anion channels.
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Cow (Bovine) Polyclonal Bestrophin 4 Primary Antibody for WB - ABIN2776288
Stöhr, Marquardt, Nanda, Schmid, Weber: Three novel human VMD2-like genes are members of the evolutionary highly conserved RFP-TM family. in European journal of human genetics : EJHG 2002
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BEST2 (show BEST2 Antibodies) and BEST4 could be added to the lineage-specific genes of humans intestinal epithelial cells
identified three novel VMD2 (show BEST1 Antibodies)-related human genes demonstrating a high degree of conservation in their respective RFP-TM domains
Human Best4 chloride channels on excised membrane patches can be activated by free calcium (Ca2 (show CA2 Antibodies)+) on the cytoplasmic side.
This gene is a member of the bestrophin gene family of anion channels. Bestrophin genes share a similar gene structure with highly conserved exon-intron boundaries, but with distinct 3' ends. Bestrophins are transmembrane proteins that contain a homologous region rich in aromatic residues, including an invariant arg-phe-pro motif. Mutation in one of the family members (bestrophin 1) is associated with vitelliform macular dystrophy. The bestrophin 4 gene is predominantly expressed in the colon.
, vitelliform macular dystrophy 2-like 2
, vitelliform macular dystrophy 2-like protein 2