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More ELISA Kits for BMPR1B Interaction Partners
Zebrafish Bone Morphogenetic Protein Receptor, Type IB (BMPR1B) interaction partners
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These results indicate a germ-cell-autonomous role for BMP signal transduction in germ-cell differentiation.
Mouse (Murine) Bone Morphogenetic Protein Receptor, Type IB (BMPR1B) interaction partners
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Study concludes that growth/differentiation factor-5 (GDF-5) protects hippocampal neurons against kainic acid-induced neurodegeneration by signaling through bone morphogenetic protein receptor type IB, suggesting a therapeutic potential for GDF-5 in neurodegenerative diseases.
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dermal BMPRIB+ cells possessed a similar osteogenic differentiation potential with BMSCs in a mouse model. Dermal BMPRIB+ subpopulations possessed low immunogenicity and immunosuppressive properties before and after osteogenic differentiation.
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BMPR1B plays distinct roles from BMPR1A and ACVR1 in maintaining bone mass and transducing BMP signaling
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This study demonistrated that BMP signaling has no major role in the development of excitatory and inhibitory synapses in the lateral superior olive.
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Local administration of adenovirus expressing siRNA-targeting BMPR-IB may be a feasible and effective therapeutic candidate to treat or prevent wear debris-associated osteolysis.
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Type Ib BMP receptors mediate the rate of commissural axon extension through inhibition of cofilin activity
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the BMP-2-BMPR-IB-ODAM-MAPK signaling cascade has important roles in ameloblast differentiation and enamel mineralization
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Variation in BMPR1B is associated with dizygotic twinning.
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signaling through BMPR1A;B performs at least two roles in early respiratory development: first, it promotes tracheal formation through repression of Sox2; and second, it restricts the site of lung bud initiation.
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These studies support a role for a functional BMP signaling axis as a tumor suppressor pathway in the ovary, with BMPR1A and BMPR1B acting downstream of BMP ligands and upstream of BMP receptor SMADs.
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results indicate a requirement for BMP signaling in generating the dorsalmost neuronal lineage of the telencephalon, DG granule neurons, and in the development of the stem cell niche that makes neurons in the adult hippocampus.
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TbetaRIII enhanced ALK6-mediated stimulation of the BMP-responsive promoters XVent2 & 3GC2, & up-regulation of the early-response gene Smad6. Interaction with ALK6 required both the extracellular & cytoplasmic domains.
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BMPR1a and BMPR1b exert directly opposing effects on the initial reactive astrocytic hypertrophy in gliosis after spinal cord injury.
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effects of loss of one of the BMP receptors, the BmprIb, on the development of the eye by using targeted deletion
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in mesenchymal progenitors bone morphogenetic protein receptor BMPR-IA is responsible for initiation of osteogenic as well as chondrogenic development and BMPR-IA and -IB receptor pathways are well separated during differentiation of mesenchymal lineages
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signaling through bone morphogenetic protein (BMP) type 1 receptors is required for the formation of two populations of commissural neurons, DI1 and DI2
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Bmpr1a and Bmpr1b play redundant roles during retinal development, and different threshold levels of Bmp signaling regulate distinct developmental programs such as patterning, growth and differentiation of the retina
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BMPR1A and BMPR1B are functionally redundant during early chondrogenesis and BMP signaling is required for chondrocyte proliferation, survival, and differentiation in vivo.
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These results provide the first evidence of multiple type I and type II BMP-receptors, expressed in the dental epithelium and mesenchyme at different stages of development, to signal different cellular activities in a time- and tissue-specific way.
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Data demonstrate that the osteogenic commitment of multipotent mouse adipose-derived adult stromal cells requires retinoic acid, which enhances expression of the critical bone morphogenetic protein receptor-IB isoform.
Human Bone Morphogenetic Protein Receptor, Type IB (BMPR1B) interaction partners
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A novel homozygous variant in BMPR1B underlies acromesomelic dysplasia Hunter-Thompson type in a consanguineous family of Pakistani origin
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the level of apoptosis was inversely proportional to the expression of bone morphogenetic protein (BMPR1B) and follicle stimulating hormone (FSH) receptors, in granulosa cells.
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Our findings show that also recessive complex digit malformation can be caused by BMPR1B variant and not all biallelic BMPR1B variants cause acromesomelic dysplasia. PDHA2 is a novel candidate gene for male infertility; the protein product is a mitochondrial enzyme with highest expression in ejaculated sperm.
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Results identified the tumor-suppressive BMPR1B regulated by miR-1274a in clear cell renal cell carcinoma.
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We detected two BMPR1B mutations in two unrelated PRS families, suggesting that BMPR1B disruption is probably a cause of human PRS.
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over-expression of CYP2J2 in MDA-MB-468-derived breast cancer cells activates BMPR1B expression that may contribute to increased migration
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BMPR1A and the ubiquitous isoform of BMPR1B differed in mode of translocation into the endoplasmic reticulum; and (ii) BMPR1A was N-glycosylated while BMPR1B was not, resulting in greater efficiency of processing and plasma membrane expression of BMPR1A.
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Mutations in three genes (GDF5, NPR2, BMPR1B) have been reported to cause different forms of acromesomelic dysplasia
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Data show that protein kinase LKB1 physically interacts with BMP type I receptors and requires Smad7 protein to promote downregulation of the receptor.
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Results show an association between age-induced depletion of the ovarian reserve and BMPR1B receptor density and suggest that the dysregulation of BMP receptor signalling may inhibit the normal steroidogenic differentiation required for maturation in older patients.
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Low expression of BMPRIB is associated with breast cancer.
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Two novel mutations in BMPR1B were identified in two patients with brachydactyly type A1.
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Using computational analyses with the COREX/BEST algorithm, the study uncovered an overall pattern connecting various regions of BMPR-1B ectodomain, including the four conserved residues in the protein-protein interface.
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Novel mutation in the BMPR1B gene (R486L) in a Polish family and further delineation of the phenotypic features of BMPR1B-related brachydactyly.
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Data found a hypomorphic BMPR1B mutation causes du Pan acromesomelic dysplasia
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Disequilibrium of BMP2 levels in the breast stem cell niche launches epithelial transformation by overamplifying BMPR1B cell response.
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Disrupting the binding of miR-125b toward BMPR1B would increase protein expression, diminishing abnormal cell proliferation as well as serum and cellular CA125 levels
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Data indicate missense (c.157T>C, p.(C53R)) or nonsense (c.657G>A, p.(W219*)) mutations in bone morphogenetic protein receptor type IB (BMPR1B) in two consanguineous families with acromesomelic chondrodysplasia-type Grebe.
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the shear-induced apoptosis and autophagy are mediated by bone morphogenetic protein receptor type (BMPR)-IB, BMPR-specific Smad1 and Smad5, and p38 mitogen-activated protein kinase.
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Using primary cells and a cell line mimicking CP-CML, we found that myeloid progenitor expansion is driven by the exposure of immature cells overexpressing BMP receptor Ib to BMP2 and BMP4.
Cow (Bovine) Bone Morphogenetic Protein Receptor, Type IB (BMPR1B) interaction partners
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MicroRNA-125b regulates apoptosis by targeting BMPR1B in yak granulosa cells.
Pig (Porcine) Bone Morphogenetic Protein Receptor, Type IB (BMPR1B) interaction partners
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These findings provide an important role of BMPRIB in the regulation of apoptosis and steroidogenesis of porcine granulosa cells.
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Report temporal regulation of BMPR1B mRNA expression in the oocyte, granulosa and theca cells of developing preovulatory follicles in the pig.
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Polymorphisms within the BMPR1B gene are associated with reproductive performance.
BMPR1B Antigen Profile
Antigen Summary
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene.
Gene names and symbols associated with BMPR1B
- bone morphogenetic protein receptor type 1B (BMPR1B) antibody
- bone morphogenetic protein receptor type 1B (bmpr1b) antibody
- bone morphogenetic protein receptor, type IBb (bmpr1bb) antibody
- bone morphogenetic protein receptor, type 1B (Bmpr1b) antibody
- bone morphogenetic protein receptor, type IBa (bmpr1ba) antibody
- bone morphogenetic protein receptor type 1B (Bmpr1b) antibody
- Acvrlk6 antibody
- AI385617 antibody
- ALK-6 antibody
- Alk6 antibody
- alk6b antibody
- alk6tr antibody
- AV355320 antibody
- BMP15 antibody
- BMPR-1B antibody
- BMPR-IB antibody
- bmpr1b antibody
- BMPRIB antibody
- BR1b antibody
- CDw293 antibody
- CFK-43a antibody
- FecB antibody
- RPK-1 antibody
- SKR6 antibody
- zALK-6 antibody
- zgc:92220 antibody
- zgc:172219 antibody
Protein level used designations for BMPR1B
BMP receptor IB , activin receptor-like kinase 6 , bone morphogenetic protein receptor type-1B , bone morphogenetic protein receptor, type IB , bone morphogenetic protein receptor type IB,b , bone morphogenetic protein receptor type-1B-like , BMP type-1B receptor , serine/threonine-protein kinase receptor R6 , alk6 , bone morphogenetic protein receptor, type 1b , BMPR-1B , serine/threonine receptor kinase , bone morphogenetic protein receptor IB , bone morphogenetic protein binding serine/threonine kinase receptor , ALK-6 , SKR6 , receptor protein kinase , bone morphogenetic protein receptor 1B
GENE ID | SPECIES |
---|---|
443454 | Ovis aries |
780089 | Xenopus (Silurana) tropicalis |
100149664 | Danio rerio |
461683 | Pan troglodytes |
705474 | Macaca mulatta |
100218713 | Taeniopygia guttata |
100397724 | Callithrix jacchus |
100444576 | Pongo abelii |
100467049 | Ailuropoda melanoleuca |
12167 | Mus musculus |
30742 | Danio rerio |
658 | Homo sapiens |
478484 | Canis lupus familiaris |
407128 | Bos taurus |
310914 | Rattus norvegicus |
396030 | Gallus gallus |
396691 | Sus scrofa |
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