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CLEC16A encodes a member of the C-type lectin domain containing family.
Showing 10 out of 82 products:
Human Polyclonal CLEC16A Primary Antibody for ELISA - ABIN314273
Hakonarson, Grant, Bradfield, Marchand, Kim, Glessner, Grabs, Casalunovo, Taback, Frackelton, Lawson, Robinson, Skraban, Lu, Chiavacci, Stanley, Kirsch, Rappaport, Orange, Monos, Devoto, Qu et al.: A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene. ... in Nature 2007
Human Polyclonal CLEC16A Primary Antibody for ELISA, WB - ABIN4299112
Skinningsrud, Husebye, Pearce, McDonald, Brandal, Wolff, Løvås, Egeland, Undlien: Polymorphisms in CLEC16A and CIITA at 16p13 are associated with primary adrenal insufficiency. in The Journal of clinical endocrinology and metabolism 2008
Human Polyclonal CLEC16A Primary Antibody for ICC, IF - ABIN4299113
Wu, Li, Chen, Yan, Jiang, Wu, Shao, Xu, Kang, Huang, Zhu, Ji, Gao: Involvement of CLEC16A in activation of astrocytes after LPS treated. in Neurochemical research 2012
Human Polyclonal CLEC16A Primary Antibody for WB - ABIN390971
Li, Jørgensen, Maggadottir, Bakay, Warnatz, Glessner, Pandey, Salzer, Schmidt, Perez, Resnick, Goldacker, Buchta, Witte, Padyukov, Videm, Folseraas, Atschekzei, Elder, Nair, Winkelmann, Gieger et al.: Association of CLEC16A with human common variable immunodeficiency disorder and role in murine B cells. ... in Nature communications 2015
Data (including data from studies using knockout and transgenic mice/cells) suggest that CLEC16A, NRDP1 (show RNF41 Antibodies), and USP8 (show USP8 Antibodies) form tripartite complex; CLEC16A-NRDP1 (show RNF41 Antibodies)-USP8 (show USP8 Antibodies) complex appears to rely on ubiquitin signals to promote mitophagy and maintain mitochondrial function necessary for beta-cell function. (CLEC16A = C-type lectin domain family 16 member A; NRDP1 (show RNF41 Antibodies) = ubiquitin-protein ligase (show UBE2K Antibodies) NRDP1 (show RNF41 Antibodies); USP8 (show USP8 Antibodies) = ubiquitin specific peptidase 8 (show USP8 Antibodies))
Golgi-associated CLEC16A negatively regulates autophagy via modulation of mTOR (show FRAP1 Antibodies) activity.
Study provides evidence that Clec16a plays a key role in the survival of Purkinje cells and in the degradative function or clearance of autolysosomes.
A possible regulatory role for the multiple sclerosis-associated rs12927355 in CLEC16A.
CLEC16A was found to be a susceptibility factor for SLE, with possible contribution to the development of the disease.
Clec16a knockdown mice showed reduced number of B cells and elevated IgM levels compared with controls.
identify CLEC16A as a pivotal gene in multiple sclerosis that serves as a direct regulator of the human leukocyte antigen class II (show HLA-DRB5 Antibodies) pathway in antigen-presenting cells.
data suggests that two polymorphisms of the CLEC16A gene play an important role in the developing of ACS in men.
This study demonstrated that the Polymorphism, Single Nucleotide of CLEC16A is associated with multiple sclerosis in Russia.
The study suggested that a CLEC16A polymorphism may be protective against Vogt-Koyanagi-Harada syndrome syndrome in a Chinese Han population.
CLEC16A associations in common variable immunodeficiency disorder represent the first robust evidence of non-HLA associations in this immunodeficiency condition.
The novel Pdx1 (show PDX1 Antibodies)-Clec16a-Nrdp1 (show RNF41 Antibodies) pathway this study describes provides a genetic basis for the pathogenesis of mitochondrial dysfunction in multiple forms of diabetes.
Islets from mice with pancreas-specific deletion of Clec16a have abnormal mitochondria with reduced oxygen consumption and ATP concentration, both of which are required for normal beta cell function, Clec16a controls beta cell function and prevents diabetes by controlling mitophagy.
This gene encodes a member of the C-type lectin domain containing family. Single nucleotide polymorphisms in introns of this gene have been associated with diabetes mellitus, multiple sclerosis and rheumatoid arthritis. Multiple transcript variants encoding different isoforms have been found for this gene.
C-type lectin domain family 16, member A
, KIAA0350 protein-like
, protein CLEC16A-like
, protein CLEC16A