CD1b Molecule Proteins (CD1B)

CD1B encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. Additionally we are shipping CD1b Antibodies (161) and CD1b Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CD1B 910 P29016
CD1B 100037709  
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Top CD1b Proteins at

Showing 7 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
Human Cells Human Fc Tag 100 μg 14 to 16 Days
HEK-293 Cells Human Fc Tag Validation with Western Blot 20 μg 6 to 10 Days
Wheat germ Human GST tag 10 μg 11 to 12 Days
Escherichia coli (E. coli) Human His tag 100 μg 15 to 19 Days
Yeast Rabbit His tag   1 mg 60 to 71 Days
Wheat germ Human Un-conjugated   10 μg 11 to 12 Days

CD1B Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , , ,

More Proteins for CD1b Molecule (CD1B) Interaction Partners

Human CD1b Molecule (CD1B) interaction partners

  1. Sulfoglycolipids (SGLs) are uniquely synthesized by Mycobacterium tuberculosis. This study designed a novel hybrid synthesis of a naturally occurring SGL, generated CD1b tetramers loaded with natural or synthetic SGL analogs, and studied the molecular requirements for T cell receptor binding and T cell activation.

  2. polyclonal germline-encoded mycolyl lipid-reactive T cell receptors that recognize CD1b-glucose-6-O-monomycolate use relatively conserved molecular mechanisms

  3. the development of polyvalent complexes of CD1b proteins and carbohydrate backbones (dextramers) and their use in identifying CD1b autoreactive T cells from human donors.

  4. [review] Humans express both Group 1 (CD1a, CD1b and CD1c) and Group 2 (CD1d) CD1 molecules with nonredundant functions in response to the presentation of endogenous lipids.

  5. for isoforms CD1b through CD1e, our simulations show the near-complete collapse of the hydrophobic cavities in the absence of the antigen. This event results from the spontaneous closure of the binding domain entrance, flanked by two alpha-helices.

  6. Dysregulated CD1 profile in myeloid dendritic cells in CVID is normalized by IVIg treatment.

  7. Molecular mechanisms by which CD1b captures distinct classes of self- and mycobacterial antigens are reviewed. Review.

  8. Deciphering the role of CD1e protein in mycobacterial phosphatidyl-myo-inositol mannosides (PIM) processing for presentation by CD1b to T lymphocytes

  9. CD1b has a mechanism for presenting either two small or one large lipid, allowing presentation of antigens with an unusually broad range of chain lengths.

  10. a cognate mechanism whereby CD1b-glycolipid complexes bind to TCRs.

  11. The DC-SIGNlow/CD86high population is characterized by a reduced CD1b expression that correlates with a reduced iMtb-specific lymphocyte proliferation together with an enhanced mixed leukocyte reaction.

  12. gammadelta T cells recognize lipid A (LA) in a CD1b- or CD1c-restricted manner in first response against Gram-bacteria, while the interaction between TLR4 on gammadelta T cells and LA might strengthen the subsequent response of gammadelta T cells.

  13. Lipid length controls antigen entry into endosomal and nonendosomal pathways for CD1b presentation.

  14. Failure of trafficking and antigen presentation by CD1b in AP-3-deficient cells

  15. CD1b and CD1c show strong binding of nitrobenzoxadiazole (NBD)-labeled dialkyl-based ligands.

  16. model proposed in which saposin C exposes lipid antigens from intralysosomal membranes for loading onto CD1b

  17. Current crystal structure illustrates for the first time the binding of a natural bacterial lipid antigen to CD1b and shows how its novel structural features fit the CD1b molecule for its role in the immune response to intracellular bacteria.

  18. CD1b expression was detected on monocytes in the majority of sickle cell anemia patients, and was highly expressed in Sbeta thalassemia patients.

  19. Expression of DC-SIGN and CD1b in human leprosy.

  20. identified CD1a-, CD1b-, and CD1c-restricted T cells from normal human donors that induce cytolysis and secrete copious IFN-gamma in response to self-CD1 expressed on monocyte-derived dendritic cells

Cow (Bovine) CD1b Molecule (CD1B) interaction partners

  1. The crystal structure of CD1b3 has been determined in complex with endogenous ligands, identified as a mixture of phosphatidylcholine and phosphatidylethanolamine, and the ability of the protein to bind mycobacterial glycolipids has been analyzed.

Rhesus Monkey CD1b Molecule (CD1B) interaction partners

  1. These results underscore substantial conservation of the group 1 CD1 system between humans and rhesus macaque monkeys.

CD1b (CD1B) Protein Profile

Protein Summary

This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail, and requires vesicular acidification to bind lipid antigens.

Gene names and symbols associated with CD1b Molecule Proteins (CD1B)

  • CD1b molecule (CD1B)
  • T-cell surface glycoprotein CD1b-3 (LOC443423)
  • CD1b1 molecule (CD1B1)
  • T-cell surface glycoprotein CD1b1 (LOC100720602)
  • CD1 protein
  • CD1-b protein
  • CD1A protein
  • CD1B protein
  • CD1B3 protein
  • R1 protein

Protein level used designations for CD1b Molecule Proteins (CD1B)

CD1B antigen, b polypeptide , T-cell surface glycoprotein CD1b , cortical thymocyte antigen CD1B , differentiation antigen CD1-alpha-3 , CD1b3 , CD1b molecule , T-cell surface glycoprotein CD1b-3 , CD1b antigen

910 Homo sapiens
509004 Bos taurus
443423 Ovis aries
457420 Pan troglodytes
718955 Macaca mulatta
100034038 Equus caballus
100037709 Oryctolagus cuniculus
100174779 Canis lupus familiaris
100599192 Nomascus leucogenys
100720602 Cavia porcellus
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