anti-CD207 Molecule, Langerin (CD207) Antibodies

The protein encoded by CD207 is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. Additionally we are shipping CD207 Proteins (13) and CD207 Kits (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CD207 246278 Q8VBX4
CD207 50489 Q9UJ71
CD207 502852  
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Top anti-CD207 Antibodies at antibodies-online.com

Showing 10 out of 132 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rat Un-conjugated IHC (fro), FACS, IHC (p) 50 μg Log in to see 8 to 10 Days
$422.62
Details
Human Rat Biotin IHC (fro), FACS 50 μg Log in to see 8 to 10 Days
$459.91
Details
Human Rat Alexa Fluor 546 IHC (fro), FACS 50 μg Log in to see 8 to 10 Days
$484.77
Details
Human Rat Alexa Fluor 647 IHC (fro), FACS 50 μg Log in to see 8 to 10 Days
$484.77
Details
Human Rat Alexa Fluor 488 IHC (fro), FACS   50 μg Log in to see 8 to 10 Days
$484.77
Details
Human Mouse Un-conjugated IHC (fro), FACS, WB 50 μg Log in to see 8 to 10 Days
$298.32
Details
Human Mouse Biotin IHC (fro), FACS, WB 50 μg Log in to see 8 to 10 Days
$335.61
Details
Human Mouse Alexa Fluor 488 IHC (fro), FACS   50 μg Log in to see 8 to 10 Days
$348.04
Details
Human Mouse Alexa Fluor 647 ICC, FACS, IF   50 μg Log in to see 8 to 10 Days
$348.04
Details
Human Mouse Alexa Fluor 546 IHC (fro), FACS   50 μg Log in to see 8 to 10 Days
$348.04
Details

Top referenced anti-CD207 Antibodies

  1. Human Monoclonal CD207 Primary Antibody for IHC (fro), FACS - ABIN786757 : Abadie, Badell, Douillard, Ensergueix, Leenen, Tanguy, Fiette, Saeland, Gicquel, Winter: Neutrophils rapidly migrate via lymphatics after Mycobacterium bovis BCG intradermal vaccination and shuttle live bacilli to the draining lymph nodes. in Blood 2005 (PubMed)
    Show all 46 Pubmed References

  2. Human Monoclonal CD207 Primary Antibody for IHC (fro), FACS - ABIN786755 : Arizon, Nudel, Segev, Mizraji, Elnekave, Furmanov, Eli-Berchoer, Clausen, Shapira, Wilensky, Hovav: Langerhans cells down-regulate inflammation-driven alveolar bone loss. in Proceedings of the National Academy of Sciences of the United States of America 2012 (PubMed)
    Show all 46 Pubmed References

  3. Human Monoclonal CD207 Primary Antibody for IHC (fro), FACS - ABIN786758 : Bachy, Hervouet, Becker, Chorro, Carlin, Herath, Papagatsias, Barbaroux, Oh, Benlahrech, Athanasopoulos, Dickson, Patterson, Kwon, Geissmann, Klavinskis: Langerin negative dendritic cells promote potent CD8+ T-cell priming by skin delivery of live adenovirus vaccine microneedle arrays. in Proceedings of the National Academy of Sciences of the United States of America 2013 (PubMed)
    Show all 46 Pubmed References

  4. Human Monoclonal CD207 Primary Antibody for IHC (fro), FACS - ABIN786754 : Bursch, Wang, Igyarto, Kissenpfennig, Malissen, Kaplan, Hogquist: Identification of a novel population of Langerin+ dendritic cells. in The Journal of experimental medicine 2007 (PubMed)
    Show all 46 Pubmed References

  5. Human Monoclonal CD207 Primary Antibody for IHC (fro), FACS - ABIN786756 : Bobr, Olvera-Gomez, Igyarto, Haley, Hogquist, Kaplan: Acute ablation of Langerhans cells enhances skin immune responses. in Journal of immunology (Baltimore, Md. : 1950) 2010 (PubMed)
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  6. Human Monoclonal CD207 Primary Antibody for IHC (fro), FACS - ABIN786759 : Bigley, Haniffa, Doulatov, Wang, Dickinson, McGovern, Jardine, Pagan, Dimmick, Chua, Wallis, Lordan, Morgan, Kumararatne, Doffinger, van der Burg, van Dongen, Cant, Dick, Hambleton, Collin: The human syndrome of dendritic cell, monocyte, B and NK lymphoid deficiency. in The Journal of experimental medicine 2011 (PubMed)
    Show all 32 Pubmed References

  7. Human Monoclonal CD207 Primary Antibody for ICC, FACS - ABIN786761 : Bonetti, Bacci, Santosuosso, Mazzanti, Aldinucci, Ballerini, Guasti, Calosi, Bosi, Romagnoli: Rosiglitazone promotes the differentiation of Langerhans cells and inhibits that of other dendritic cell types from CD133 positive hematopoietic precursors. in Histology and histopathology 2014 (PubMed)
    Show all 32 Pubmed References

  8. Human Monoclonal CD207 Primary Antibody for IHC (fro), FACS - ABIN786762 : Debeer, Le Luduec, Kaiserlian, Laurent, Nicolas, Dubois, Kanitakis: Comparative histology and immunohistochemistry of porcine versus human skin. in European journal of dermatology : EJD 2013 (PubMed)
    Show all 32 Pubmed References

  9. Human Monoclonal CD207 Primary Antibody for IHC (fro), FACS - ABIN786763 : de Jong, de Witte, Taylor, Geijtenbeek: Herpes simplex virus type 2 enhances HIV-1 susceptibility by affecting Langerhans cell function. in Journal of immunology (Baltimore, Md. : 1950) 2010 (PubMed)
    Show all 32 Pubmed References

  10. Human Monoclonal CD207 Primary Antibody for IHC (fro), FACS - ABIN786760 : Eisenwort, Jurkin, Yasmin, Bauer, Gesslbauer, Strobl: Identification of TROP2 (TACSTD2), an EpCAM-like molecule, as a specific marker for TGF-?1-dependent human epidermal Langerhans cells. in The Journal of investigative dermatology 2011 (PubMed)
    Show all 32 Pubmed References

More Antibodies against CD207 Interaction Partners

Mouse (Murine) CD207 Molecule, Langerin (CD207) interaction partners

  1. Data show that the development of langerhans cells (LC) from embryonic and bone marrow-derived progenitors and langerin(+ )conventional dendritic cells (DC) is regulated by the retinoic acid receptor alpha (RARalpha)-retinoic acid (RA) axis.

  2. Binding analysis between purified long and short forms of langerin and a series of keratin sulfate disaccharide components shows that the binding critically requires the 6-sulfation of Gal and that the long form of langerin displays higher affinity than the short form.

  3. Bacterial Polysaccharide Specificity of the Pattern Recognition Receptor Langerin Is Highly Species-dependent

  4. Data show that Candida albicans and Candida tropicalis preferentially localized in (and persisted within) a sub- population of Peyer's patch Langerin-positive dendritic cells.

  5. Langerin is expressed by the XCR1(+) "DC1" population of mice.

  6. Langerin+ dermal dendritic cells appear to be site- and strain-specific

  7. TLR7-activated langerin(neg) dendritic cells trigger psoriatic plaque formation via IL-23-mediated activation of innate IL-17/IL-22-producing lymphocytes, independently of IFN-I.

  8. model of epicutaneous ovalbumin sensitization inducing an inflammatory skin resembling atopic dermatitis (AD) to explore the role of CD207 in the pathogenesis of AD

  9. Langerin-positive dendritic cells appear to be the predominant, though not exclusive, population responsible for in vivo transport of anti-DEC-205 antibodies from the skin to the draining lymph nodes in steady state and inflammation.

  10. Data demonstrated that CD207(+) CD8alpha(+) thymic DCs do not share a common origin with T cells but originate from intrathymic precursors.

  11. The normal corneal epithelium is endowed with CD11c(+) Langerin+ cells that are LCs, whereas the stroma is endowed with a separate population of (non-LC) Langerin+ DCs.

  12. Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A.

  13. Langerhan cells and (Langerin(+)) dermal dendritic cells thus seem to have a redundant function in regulating contact hypersensitivity

  14. molecular cloning and expression of Langerin transcripts in dendritic cells

  15. Developmentally regulated expression of Langerin isoforms provides a mechanism by which Langerin involvement in antigen uptake and processing could be regulated.

  16. CD207 has a role in maintaining Birbeck granules but not in Langerhans cell function

  17. Langerin may have an unanticipated role in cell-matrix interactions that modulate LC development, localization, or function

  18. CD207 antigens manifest a high degree of colocalization around the nucleus of the Langerhans cells.

  19. langerin(+) DCs patrol the dermis in the steady state and migrate to the skin DLNs charged with skin antigens

  20. dermal Langerin(+) dendritic cells (DCs) are radiosensitive and display a distinct cell surface phenotype

Human CD207 Molecule, Langerin (CD207) interaction partners

  1. Binding analysis between purified long and short forms of langerin and a series of keratin sulfate disaccharide components shows that the binding critically requires the 6-sulfation of Gal and that the long form of langerin displays higher affinity than the short form.

  2. CD207(+)CD1a(+) cells are circulating in patients with active Langerhans cell histiocytosis, and TSLP and TGF-beta are potential drivers of Langerhans-like cells in vivo.

  3. the data provide evidence that human Langerhans cells are able to cross-present antigens after langerin-mediated internalization.

  4. Calcium-independent activation of an allosteric network in langerin by heparin oligosaccharides has been reported.

  5. Bacterial Polysaccharide Specificity of the Pattern Recognition Receptor Langerin Is Highly Species-dependent

  6. Kinetic and Structural Studies of Interactions between Glycosaminoglycans and Langerin

  7. We suggest that CD207 gene polymorphisms rs13421115 and rs17718987 increase the risk of development of end-stage renal disease.

  8. This study shows that mutations in the Langerin gene are present in the analysed populations at different genotypic and allelic frequencies and further studies should be conducted to verify the role of these mutations in HIV-1 susceptibility.

  9. This study is the first to demonstrate that langerin represents an authentic receptor that binds and internalizes influenza A virus to facilitate infection.

  10. Data suggest that Langerin (CD207)-mediated binding of Yersinia pestis to antigen-presenting cells (APCs) may promote its dissemination and infection.

  11. Langerin binds heparin (HEP)-like oligosaccharides in two different binding sites depending on the ligand size.

  12. The authors not only show that langerin and caveolin-1 co-localize at the cell membrane and in vesicles but that caveolin-1 mediated HIV-1 uptake is an intrinsic restriction mechanism present in human Langerhans cells that prevents HIV-1 infection.

  13. The impact of two carbohydrate recognition domains mutations, W264R and F241L, on langerin structure, function, and Birbeck granules assembly.

  14. Langerin is not expressed by freshly isolated CD1c(+) blood DCs but is rapidly induced on CD1c(+) DCs by serum or TGF-beta via an ALK-3-dependent pathway.

  15. Cell-sorting experiments demonstrated that IDO1 expression is found in a subset of CD1a(+)CD14(-)langerin(+) cells, expressing CD103

  16. However, the superoxide dismutase C (SodC) protein of the Mycobacterium leprae cell wall was identified as a langerin-reactive ligand.

  17. Both phases of HIV transfer from eLCs to T cells were inhibited when eLCs were pretreated with a mAb to langerin CRD or when HIV was pretreated with a soluble langerin trimeric extracellular domain or by a CRD homolog.

  18. Altered langerin function in individuals with the linked N288D and K313I polymorphisms may affect susceptibility to infection by microorganisms.

  19. binding properties of langerin

  20. A langerin-cre recombinase transgenic knockin mouse strain is generated that efficiently targets Langerhans cells and other langerin-positive dendritic cells, in particular, in the dermis and the lung.

CD207 Antigen Profile

Protein Summary

The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity.

Gene names and symbols associated with CD207

  • CD207 molecule (CD207) antibody
  • CD207 antigen (Cd207) antibody
  • CD207 molecule (Cd207) antibody
  • CD207 antibody
  • CLEC4K antibody
  • RGD1565913 antibody

Protein level used designations for CD207

CD207 molecule, langerin , CD207 antigen, langerin , C-type lectin domain family 4 member K , Langerhans cell specific c-type lectin , langerin , C-type lectin domain family 4, member K , CD 207 antigen

GENE ID SPECIES
511000 Bos taurus
703420 Macaca mulatta
737419 Pan troglodytes
100580491 Nomascus leucogenys
246278 Mus musculus
50489 Homo sapiens
100037935 Sus scrofa
502852 Rattus norvegicus
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