anti-CD207 Molecule, Langerin (CD207) Antibodies

Mouse (Murine) CD207 Molecule, Langerin (CD207) interaction partners

1. Data show that the development of langerhans cells (LC) from embryonic and bone marrow-derived progenitors and langerin(+ )conventional dendritic cells (DC) is regulated by the retinoic acid receptor alpha (RARalpha)-retinoic acid (RA) axis.

2. Binding analysis between purified long and short forms of langerin and a series of keratin sulfate disaccharide components shows that the binding critically requires the 6-sulfation of Gal and that the long form of langerin displays higher affinity than the short form.

3. Bacterial Polysaccharide Specificity of the Pattern Recognition Receptor Langerin Is Highly Species-dependent

4. Data show that Candida albicans and Candida tropicalis preferentially localized in (and persisted within) a sub- population of Peyer's patch Langerin-positive dendritic cells.

5. Langerin is expressed by the XCR1(+) "DC1" population of mice.

6. Langerin+ dermal dendritic cells appear to be site- and strain-specific

7. TLR7-activated langerin(neg) dendritic cells trigger psoriatic plaque formation via IL-23-mediated activation of innate IL-17/IL-22-producing lymphocytes, independently of IFN-I.

8. model of epicutaneous ovalbumin sensitization inducing an inflammatory skin resembling atopic dermatitis (AD) to explore the role of CD207 in the pathogenesis of AD

9. Langerin-positive dendritic cells appear to be the predominant, though not exclusive, population responsible for in vivo transport of anti-DEC-205 antibodies from the skin to the draining lymph nodes in steady state and inflammation.

10. Data demonstrated that CD207(+) CD8alpha(+) thymic DCs do not share a common origin with T cells but originate from intrathymic precursors.

11. The normal corneal epithelium is endowed with CD11c(+) Langerin+ cells that are LCs, whereas the stroma is endowed with a separate population of (non-LC) Langerin+ DCs.

12. Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A.

13. Langerhan cells and (Langerin(+)) dermal dendritic cells thus seem to have a redundant function in regulating contact hypersensitivity

14. molecular cloning and expression of Langerin transcripts in dendritic cells

15. Developmentally regulated expression of Langerin isoforms provides a mechanism by which Langerin involvement in antigen uptake and processing could be regulated.

16. CD207 has a role in maintaining Birbeck granules but not in Langerhans cell function

17. Langerin may have an unanticipated role in cell-matrix interactions that modulate LC development, localization, or function

18. CD207 antigens manifest a high degree of colocalization around the nucleus of the Langerhans cells.

19. langerin(+) DCs patrol the dermis in the steady state and migrate to the skin DLNs charged with skin antigens

20. dermal Langerin(+) dendritic cells (DCs) are radiosensitive and display a distinct cell surface phenotype

Human CD207 Molecule, Langerin (CD207) interaction partners

1. Binding analysis between purified long and short forms of langerin and a series of keratin sulfate disaccharide components shows that the binding critically requires the 6-sulfation of Gal and that the long form of langerin displays higher affinity than the short form.

2. CD207(+)CD1a(+) cells are circulating in patients with active Langerhans cell histiocytosis, and TSLP and TGF-beta are potential drivers of Langerhans-like cells in vivo.

3. the data provide evidence that human Langerhans cells are able to cross-present antigens after langerin-mediated internalization.

4. Calcium-independent activation of an allosteric network in langerin by heparin oligosaccharides has been reported.

5. Bacterial Polysaccharide Specificity of the Pattern Recognition Receptor Langerin Is Highly Species-dependent

6. Kinetic and Structural Studies of Interactions between Glycosaminoglycans and Langerin

7. We suggest that CD207 gene polymorphisms rs13421115 and rs17718987 increase the risk of development of end-stage renal disease.

8. This study shows that mutations in the Langerin gene are present in the analysed populations at different genotypic and allelic frequencies and further studies should be conducted to verify the role of these mutations in HIV-1 susceptibility.

9. This study is the first to demonstrate that langerin represents an authentic receptor that binds and internalizes influenza A virus to facilitate infection.

10. Data suggest that Langerin (CD207)-mediated binding of Yersinia pestis to antigen-presenting cells (APCs) may promote its dissemination and infection.

11. Langerin binds heparin (HEP)-like oligosaccharides in two different binding sites depending on the ligand size.

12. The authors not only show that langerin and caveolin-1 co-localize at the cell membrane and in vesicles but that caveolin-1 mediated HIV-1 uptake is an intrinsic restriction mechanism present in human Langerhans cells that prevents HIV-1 infection.

13. The impact of two carbohydrate recognition domains mutations, W264R and F241L, on langerin structure, function, and Birbeck granules assembly.

14. Langerin is not expressed by freshly isolated CD1c(+) blood DCs but is rapidly induced on CD1c(+) DCs by serum or TGF-beta via an ALK-3-dependent pathway.

15. Cell-sorting experiments demonstrated that IDO1 expression is found in a subset of CD1a(+)CD14(-)langerin(+) cells, expressing CD103

16. However, the superoxide dismutase C (SodC) protein of the Mycobacterium leprae cell wall was identified as a langerin-reactive ligand.

17. Both phases of HIV transfer from eLCs to T cells were inhibited when eLCs were pretreated with a mAb to langerin CRD or when HIV was pretreated with a soluble langerin trimeric extracellular domain or by a CRD homolog.

18. Altered langerin function in individuals with the linked N288D and K313I polymorphisms may affect susceptibility to infection by microorganisms.

19. binding properties of langerin

20. A langerin-cre recombinase transgenic knockin mouse strain is generated that efficiently targets Langerhans cells and other langerin-positive dendritic cells, in particular, in the dermis and the lung.