CD207 antibody

Catalog No. ABIN7505884

The Mouse Monoclonal anti-CD207 antibody is suitable to detect CD207 in samples from Human and Non-Human Primate. It has been validated for ELISA, FACS, ICC and IHC (fro).

Quick Overview for CD207 antibody (ABIN7505884)

Target: CD207 (CD207 Molecule, Langerin (CD207))

Reactivity: Human, Non-Human Primate

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD207 antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 2G3

Product Details anti-CD207 Antibody

Purpose: Anti-Hu CD207 Purified

Characteristics: The mouse monoclonal antibody 2G3 recognizes an extracellular/luminal epitope of CD207, a transmembrane protein selectively expressed by Langerhans cells and by some other dendritic cell subsets. This antibody clone can target vaccine-peptides to dendritic cells.

Purification: Purified by protein-A affinity chromatography.

Immunogen: Fusion protein of human CD207 extracellular part and IgG Fc fragment

Isotype: IgG1 lambda

Application Details

Application Notes: Flow cytometry: Recommended dilution: 0.5-4 μg/mL. Extracellular and intracellular staining.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do not freeze

Storage: 4 °C

Storage Comment: Store at 2-8°C. Do not freeze.

Target Details for CD207

Target: CD207 (CD207 Molecule, Langerin (CD207))

Alternative Name: CD207

Background: CD207 Molecule,CD207 is a 40 kDa type II transmembrane glycoprotein of the C-type lectin family. It binds to mannose-bearing glycoproteins and glycolipids of microbial and viral antigens, including HIV gp120. CD207 is expressed only in Langerhans cells, which are immature dendritic cells of the epidermis and mucosa, and its expression decreases during Langerhans cells maturation. Upon antigen binding CD207 localizes to the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed membranes, which leads to a nonclassical antigen-processing pathway.,CLEC4K, langerin

Gene ID: 50489

UniProt: Q9UJ71