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The protein encoded by CINP interacts with CDK2, MCM5, and CDC7, and is associated with the origin recognition complex protein ORC2.
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NS5B delays cells in S phase through interaction with CINP and relocalization of the protein from the nucleus to the cytoplasm
CINP is part of the Cdc7-dependent mechanism of origin firing and a functional and physical link between Cdk2 and Cdc7 complexes at the origins
CINP interacts with ATR-interacting protein and regulates ATR-dependent signaling, resistance to replication stress, and G2 checkpoint integrity.
The protein encoded by this gene interacts with CDK2, MCM5, and CDC7, and is associated with the origin recognition complex protein ORC2. It acts as a homodimer and is involved in replication and ATR-mediated checkpoint signaling. Three transcript variants encoding different isoforms have been found for this gene.
cyclin-dependent kinase 2-interacting protein
, CDK2-interacting protein