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CMTM4 belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules.
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Human Polyclonal CMTM4 Primary Antibody for IHC, IHC (p) - ABIN4299310
Bei, Zhang, Wei, Zhu, Wang, Zeng, Chen, Tan: Clinical significance of CMTM4 expression in hepatocellular carcinoma. in OncoTargets and therapy 1970
CMTM6 (show CMTM6 Antibodies) is present at the cell surface, associates with the PD-L1 (show CD274 Antibodies) protein, reduces its ubiquitination and increases PD-L1 (show CD274 Antibodies) protein half-life; CMTM6 (show CMTM6 Antibodies) enhances the ability of PD-L1 (show CD274 Antibodies)-expressing tumour cells to inhibit T cells; collectively, our data reveal that PD-L1 (show CD274 Antibodies) relies on CMTM6 (show CMTM6 Antibodies)/4 to efficiently carry out its inhibitory function, and suggest potential new avenues to block this pathway
CMTM4 is downregulated and exhibits tumour-suppressor activities in clear cell renal cell carcinoma (show MOK Antibodies), and could be exploited as a target for clear cell renal cell carcinoma (show MOK Antibodies) treatment.
Data show that CMTM4 might be an important gene involved in cell growth and cell cycle regulation.
Bioinformatics based on CKLF2 (show CKLF Antibodies) cDNA and protein sequences in combination with experimental validation identified CKLFSF1 (show CMTM1 Antibodies)-8 gene clusters, between the SCY (show CELSR1 Antibodies) and the TM4SF (show TSPAN1 Antibodies) gene families. The 8 family members were cloned and characterized.
This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. Alternatively spliced transcript variants encoding different isoforms have been identified.
CKLF-like MARVEL transmembrane domain-containing protein 4
, chemokine-like factor super family 4
, chemokine-like factor superfamily member 4
, chemokine-like factor superfamily 4