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CMTM6 belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. Additionally we are shipping CMTM6 Kits (41) and CMTM6 Proteins (6) and many more products for this protein.
Showing 10 out of 30 products:
Human Polyclonal CMTM6 Primary Antibody for ICC, IF - ABIN441218
Zhu, Qi, Li, Bei, Tan, Zhang, Shi, Zeng, Kong, Fu, Tan: Expression and Clinical Significance of CMTM6 in Hepatocellular Carcinoma. in DNA and cell biology 2019
Downregulation of CMTM6 is related to HCC metastasis and the prognosis of HCC patients.
CMTM6 plays an important role in regulating T cell activation and antitumor responses.
CMTM6 is present at the cell surface, associates with the PD-L1 protein, reduces its ubiquitination and increases PD-L1 protein half-life; CMTM6 enhances the ability of PD-L1-expressing tumour cells to inhibit T cells; collectively, our data reveal that PD-L1 relies on CMTM6/4 to efficiently carry out its inhibitory function, and suggest potential new avenues to block this pathway
CMTM6 depletion, via the reduction of PD-L1, significantly alleviates the suppression of tumour-specific T cell activity in vitro and in vivo; findings provide insights into the biology of PD-L1 regulation, identify a previously unrecognized master regulator of this critical immune checkpoint and highlight a potential therapeutic target to overcome immune evasion by tumour cells
Bioinformatics based on CKLF2 cDNA and protein sequences in combination with experimental validation identified CKLFSF1-8 gene clusters, between the SCY and the TM4SF gene families. The 8 family members were cloned and characterized.
This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene is widely expressed in many tissues, but the exact function of the encoded protein is unknown.
CKLF-like MARVEL transmembrane domain-containing protein 6
, chemokine-like factor super family 6
, chemokine-like factor superfamily 6
, CKLF-like MARVEL transmembrane domain containing 6
, chemokine-like factor superfamily member 6