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CMTM7 belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies.
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Findings indicate the role of CMTM7 protein in the regulation of epidermal growth factor receptor (EGFR (show EGFR Antibodies))-AKT (show AKT1 Antibodies) proto-oncogene (show RAB1A Antibodies) protein signaling in tumor cells, and as a molecule related to Rab5 (show RAB5A Antibodies) GTP-binding protein (show HCAR3 Antibodies) activation.
Loss of CMTM7 by promoter CpG methylation is associated with neoplasms.
The CMTM7 expression may be related to survival of patients with non-smallcell lung cancer and a unique prognostic factor. CMTM7 may play an important role in NSCLC development.
CMTM7 functions to link sIgM and BLNK (show BLNK Antibodies) in the plasma membrane.
Bioinformatics based on CKLF2 (show CKLF Antibodies) cDNA and protein sequences in combination with experimental validation identified CKLFSF1 (show CMTM1 Antibodies)-8 gene clusters, between the SCY (show CELSR1 Antibodies) and the TM4SF (show TSPAN1 Antibodies) gene families. The 8 family members were cloned and characterized.
The reduction of B-1a cells in Cmtm7(flox/) mice was associated with reduced BCR (show BCR Antibodies) expression.
This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. The protein encoded by this gene is highly expressed in leukocytes, but its exact function is unknown. Alternatively spliced transcript variants encoding different isoforms have been identified.
CKLF-like MARVEL transmembrane domain-containing protein 7
, chemokine-like factor super family 7
, chemokine-like factor super family member 7 variant 2
, chemokine-like factor superfamily 7
, chemokine-like factor superfamily member 7
, CKLF-like MARVEL transmembrane domain containing 7 L homeolog