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Associates with the NF-kappa-B complex and suppresses its transcriptional activity (By similarity). Additionally we are shipping COMM Domain Containing 7 Antibodies (20) and COMM Domain Containing 7 Kits (12) and many more products for this protein.
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COMMD7 activates CXCL10 (show CXCL10 Proteins) production by regulating NFkappaB (show NFKB1 Proteins) and the production of ROS (show ROS1 Proteins). The present study highlighted the role of COMMD7 in the development of HCC (show FAM126A Proteins), and provides novel options for anticancer drug design.
COMMD7 up-regulation is correlated with a novel NF-kappaB (show NFKB1 Proteins) positive feedback loop in hepatocellular carcinoma, regulation cell proliferation, cell migration and apoptosis.
High COMMD7 expression was specifically detected in pancreatic ductal adenocarcinoma tissues and pancreatic ductal adenocarcinoma cell lines. In addition, COMMD7 overexpression positively correlated with histological differentiation and tumor node metastasis (TNM (show ODZ1 Proteins)) stage.
The present data suggests a potential role of CXCL10 (show CXCL10 Proteins) in the oncogenic function of COMMD7.
COMMD7's binding to NEMO (show IKBKG Proteins) does not interfere with the binding to the IKKs, and that the disruption of the IKK (show CHUK Proteins) complex through the use of the NBP (show NUBP1 Proteins) competitor impairs the termination of NF-kappaB (show NFKB1 Proteins) activity
COMMD7 contributes to hepatocellular carcinoma progression by reducing cell apoptosis and overcoming cell cycle arrest.
Associates with the NF-kappa-B complex and suppresses its transcriptional activity (By similarity).
COMM domain containing 7
, COMM domain-containing protein 7