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Associates with the NF-kappa-B complex and suppresses its transcriptional activity (By similarity). Additionally we are shipping COMM Domain Containing 7 Antibodies (20) and COMM Domain Containing 7 Kits (12) and many more products for this protein.
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COMMD7 activates CXCL10 production by regulating NFkappaB and the production of ROS. The present study highlighted the role of COMMD7 in the development of HCC, and provides novel options for anticancer drug design.
COMMD7 up-regulation is correlated with a novel NF-kappaB positive feedback loop in hepatocellular carcinoma, regulation cell proliferation, cell migration and apoptosis.
High COMMD7 expression was specifically detected in pancreatic ductal adenocarcinoma tissues and pancreatic ductal adenocarcinoma cell lines. In addition, COMMD7 overexpression positively correlated with histological differentiation and tumor node metastasis (TNM) stage.
The present data suggests a potential role of CXCL10 in the oncogenic function of COMMD7.
COMMD7's binding to NEMO does not interfere with the binding to the IKKs, and that the disruption of the IKK complex through the use of the NBP competitor impairs the termination of NF-kappaB activity
COMMD7 contributes to hepatocellular carcinoma progression by reducing cell apoptosis and overcoming cell cycle arrest.
BC047440 can promote the growth and invasion of hepatocellular carcinoma.
Associates with the NF-kappa-B complex and suppresses its transcriptional activity (By similarity).
COMM domain containing 7
, COMM domain-containing protein 7