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The protein encoded by CAST is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. Additionally we are shipping Calpastatin Antibodies (84) and Calpastatin Kits (18) and many more products for this protein.
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Human Calpastatin Protein expressed in Escherichia coli (E. coli) - ABIN935258
Zór, Ortiz, Saatci, Bardsley, Parr, Csöregi, Nistor: Label free capacitive immunosensor for detecting calpastatin--a meat tenderness biomarker. in Bioelectrochemistry (Amsterdam, Netherlands) 2009
single nucleotide polymorphisms in CAST gene confer risk for keratoconus susceptibility in Han Chinese population
Kaposi sarcoma-associated herpesvirus reduces CAST (calpastatin) and consequently decreases ATG5 expression in both THP-1 monocytoid cells and primary monocytes.
calpains and calpastatin in patients with idiopathic pulmonary arterial hypertension (PAH) and mice with hypoxic or spontaneous (SM22 (show TAGLN Proteins)-5HTT (show SLC6A4 Proteins)(+) strain) PH, were investigated.
Loss of CAST in angiogenic ECs facilitates mu (show JAK3 Proteins)-calp (show STAT1 Proteins)ain-induced SOCS3 degradati (show SOCS3 Proteins)on, which amplifies p (show VEGFC Proteins)athological angiogenesis through interleukin-6/STAT3/VEGF-C axis.
We describe PLACK syndrome, as a clinical entity of defective epidermal adhesion, caused by loss-of-function mutations in calpastatin.
Calpastatin binds with Cav1.2 (show CACNA1C Proteins) amino acid motifs in a calcium dependent manner.
Calpastatin gene (CAST) is not associated with late onset sporadic Parkinson's disease in the Han Chinese population.
HER2 (show ERBB2 Proteins) inhibited calpain-1 (show CAPN1 Proteins) activity through upregulating calpastatin, an endogenous calpain inhibitor.
The results suggest that calpain-2 (show CAPN2 Proteins) and calpastatin expression is important in pancreatic cancers, influencing disease progression
Neuronal overexpression of calpastatin modulates amyloid precursor protein (show APP Proteins) processing in brains of transgenic beta-amyloid depositing mice.
Defective scar formation after myocardial infarction in calpastatin transgenic mice was associated with blunted CD4 (show CD4 Proteins)(+) T-cell and M2-macrophage recruitment.
Over-expression of Cast inhibits calpain activation and attenuates post-infarction myocardial remodeling.
EC-specific transgenic CAST downregulated JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins) signals, upregulated SOCS3 (show SOCS3 Proteins), and depleted VEGF-C (show VEGFC Proteins), counteracting unstable pathological neovessels and disease progression in tumors and oxygen-induced retinopathy lesions in mice.
Overexpression of the calpain-specific inhibitor calpastatin reduces human alpha-synuclein processing, aggregation and synaptic impairment in transgenic mice.
We observed that ischemia induction results in increased expression of CaN, Calp (show KCNIP4 Proteins) and Calpn.
Over-expression of calpastatin enhances doxorubicin-induced cardiac injuries through calpain inhibition.
The calpain/calpastatin system has opposing roles in growth and metastatic dissemination of melanoma.
Data show that genetic deficiency of calpastatin (CS) augmented Abeta (show APP Proteins) amyloidosis, tau phosphorylation, microgliosis, and somatodendritic dystrophy, and increased mortality in amyloid precursor protein (APP (show APP Proteins)) transgenic mice.
PIN1 apparently restrains the ability of calpastatin to inhibit calpain, maintaining calpain activity in endothelial cells.
The calpastatin gene (CAST), which is located on bovine chromosome 7 (BTAU7), is considered a strong functional candidate for meat tenderness in livestock species.
The suppression of calpastatin resulted in the increased expression of mu-calpain (show CAPNL1 Proteins), caspases, and HSPs which in turn regulate apoptotic cell death.
This work is supportive of the importance of CAPN1 (show CAPNL1 Proteins) and CAST for mean tenderness in beef.
bovine CAPN-CAST interaction were well reflected in the geometry between the pharmacophore features and its shape constraints identified using our modeled bovine CAPN1 (show CAPNL1 Proteins)/CAST4 complex structures
CAST binds and inhibits CAPN via its CAPN-inhibitor domains(CAST1-4) .CAST4 docks near the flexible active site of CAPN1 (show CAPNL1 Proteins), conformational changes at the interaction site after binding could be directly related to CAST4 inhibitory activity.
This work confirms the importance of CAPN1 (show CAPNL1 Proteins) and CAST for tenderness in beef, provides a new effect of CAST on beef tenderness, and questions the utility of GHR (show GHR Proteins) as a selection marker for beef quality.
The association of single nucleotide polymorphisms in calpastatin with muscle tenderness was studied.
Association of polymorphisms in calpain 1 (show CAPN1 Proteins), (mu/I) large subunit, calpastatin, and cathepsin D (show CTSD Proteins) genes with meat quality traits in double-muscled Piemontese cattle.
The CAST28 genotypes showing allele frequencies of C (0.429) and T (0.571) were significantly associated with calpastatin activity and Warner-Bratzler Shear Force in beef.
The association of polymorphisms in calpastatin and mu-calpain (show CAPNL1 Proteins) genes with meat tenderness in 3 French beef breeds is reported.
CT1 (show SLC6A8 Proteins) decreases cell death through a mechanism related to Stat3 (show STAT3 Proteins) and Akt (show AKT1 Proteins) phosphorylation and activation of calpastatin in D-galactosamine-treated hepatocytes.
CAST gene affected post-mortem activation time of calpain and drip loss.
The quality of meat influenced by RYR1 (show RYR1 Proteins) genotype may be modified by the simultaneous influence of genotype as regards the CAST locus
The effect of the beta-adrenergic agonist clenbuterol and porcine ST (pST (show SULT1A1 Proteins)) treatment on calpastatin promoter usage in vivo and in vitro are reported.
The Decreased expression of calpastatin mRNA during development is highly correlated with muscle protein accumulation in neonatal Sus scrofa.
The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described.
, sperm BS-17 component
, calpastatin type III
, calpastatin isoform III
, calpastatin type I
, calpastatin type II