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Cnrip1 encodes a G-protein coupled receptor which interacts with the C-terminal tail of cannabinoid receptor 1. Additionally we are shipping Cnrip1 Antibodies (20) and Cnrip1 Kits (7) and many more products for this protein.
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The results suggest an instructive role of Xenopus laevis cnrip1 in early eye and neural development.
The Arg82 and Cys126 of CRIP1b are involved in the majority of hydrogen bond interactions with the CB1 receptor and are possible key residues required for interactions between the CB1 receptor and CRIP1b
CNRIP1 and RUNX3 as potential DNA methylation biomarkers for CRC diagnosis and treatment
CRIP1a can compete with beta-arrestins for interaction with C-terminal CB1R domains that could affect agonist-driven, beta-arrestin-mediated internalization of the CB1R.
Ddata indicate that cannabinoid receptor-interacting protein 1a enhances hippocampal cannabinoid type 1 receptor signaling in vivo.
These studies demonstrate a novel role for CRIP1a in agonist-driven CB1 R cell surface regulation postulated to occur by two mechanisms: 1) attenuating internalization that is agonist-mediated, but not that in the absence of exogenous agonists, and 2) biased agonist-dependent trafficking of de novo synthesized receptor to the cell surface
Endogenous levels of CRIP1a modulate CB1R-mediated signal transduction by facilitating a Gi/o protein subtype preference for Gi1 and Gi2, accompanied by an overall suppression of G-protein-mediated signaling in neuronal cells.
CRIP1a appears to act as a broad negative regulator of CB1 receptor function
sequential activation of muscarinic M3 receptors and cannabinoid CB1 receptors produce synergistic contractile effects of the bovine ciliary muscle by involving the activation of Rho-kinase and protein kinase C.
This gene encodes a G-protein coupled receptor which interacts with the C-terminal tail of cannabinoid receptor 1. This receptor plays a role in synaptic plasticity, analgesia, appetite, and neuroprotection. Two transcript variants encoding different isoforms have been described for this gene.
cannabinoid receptor interacting protein 1
, CB1 cannabinoid receptor-interacting protein 1
, cannabinoid receptor CB1-interacting protein 1
, CB1 cannabinoid receptor interacting
, cannabinoid receptor interacting protein 1 ortholog