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CHST4 encodes an N-acetylglucosamine 6-O sulfotransferase.
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GlcNAc6ST-2, whose expression is regulated by butyrate, is a major sulfotransferase in the biosynthesis of sulfomucins in the mouse colon, where they serve as a mucosal barrier against colonic inflammation
GST-3 is responsible for MECA-79 defined luminal ligands
N-acetylglucosamine-6-O-sulfotransferases (GlcNAc6ST-1 (show CHST2 ELISA Kits) and GlcNAc6ST-2) deficiency results in elimination of both peripheral node addressin and sialyl 6-sulfo Lewis X (show FUT4 ELISA Kits) in high endothelial venules.
Data suggest that GlcNAc6ST-2 (CHST4) is critical for biosynthesis of MECA-79 sulfated (show SULF1 ELISA Kits) glycans in apical membranes of small-sized intrahepatic bile ducts and of cholangiolocellular carcinoma (CoCC) cells; MUC1 (show MUC1 ELISA Kits) protein decorated with GlcNAc6ST-2-dependent MECA-79 sulfated (show SULF1 ELISA Kits) glycans may serve as a useful CoCC marker.
A method for O-GlcNAc (show OGT ELISA Kits) detection using in vitro sulfation with two N-acetylglucosamine (GlcNAc)-specific sulfotransferases, carbohydrate sulfotransferase 2 (show CHST2 ELISA Kits) and carbohydrate sulfotransferase 4.
GlcNAc6ST2 could therefore be a good serological marker for detecting early-stage uterine cervical and corpus cancers.
Ectopic expression of a GlcNAc 6-O-sulfotransferase, GlcNAc6ST-2, in colonic mucinous adenocarcinoma
N-acetylgluosamine-6-O-sulfotransferase is overexpressed in a subgroup of paediatric precursor-B acute lymphoblastic leukaemia
This gene encodes an N-acetylglucosamine 6-O sulfotransferase. The encoded enzyme transfers sulfate from 3'phosphoadenosine 5'phospho-sulfate to the 6-hydroxyl group of N-acetylglucosamine on glycoproteins. This protein is localized to the Golgi and is involved in the modification of glycan structures on ligands of the lymphocyte homing receptor L-selectin. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein.
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
, carbohydrate sulfotransferase 4-like
, L-selectin ligand sulfotransferase
, N-acetylglucosamine 6-O-sulfotransferase 2
, carbohydrate sulfotransferase 4
, galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 3
, high endothelial cell GlcNAC-6-sulphotransferase
, high endothelial cells N-acetylglucosamine 6-O-sulfotransferase
, galactose/N-acetylglucosamine/N-acetylgalactosamine 6-O-sulfotransferase 3
, carbohydrate (chondroitin 6/keratan) sulfotransferase 4