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Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. Additionally we are shipping Carbonic Anhydrase VA Proteins (9) and Carbonic Anhydrase VA Kits (2) and many more products for this protein.
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In this report, genetic knockdown and overexpression studies confirm that mitochondrial CA VA regulates respiration in pericytes, whereas mitochondrial CA VB (show CA5B Antibodies) does not contribute significantly. Identification of mitochondrial CA VA as a sole regulator of respiration provides a specific target to develop new drugs with fewer side effects that may be better tolerated and can protect the brain from diabetic injury.
both Car5A and Car5B (show CA5B Antibodies) contribute to both ammonia detoxification (ureagenesis) and regulation of fasting blood sugar (gluconeogenesis).
In 10 of 96 patients, mutations in CA5A were identified on both alleles but none in CA5B (show CA5B Antibodies). Exhibiting decreased enzyme activity or thermal stability, all CAVA mutations were proven to cause disease, whereas the three variants showed no relevant effect
CA5A alterations cause hyperammonemia in early childhood that result in mitochondrial carbonic anhydrase VA deficiency
activators enhanced kcat, with no effect on KM, favoring the RDS (show PRPH2 Antibodies) in the catalytic cycle; the activation pattern of the two mitochondrial isoforms is very different from each other and as compared to those of the cytosolic isoforms hCA I and II.
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA VA is localized in the mitochondria and expressed primarily in the liver. It may play an important role in ureagenesis and gluconeogenesis. CA5A gene maps to chromosome 16q24.3 and an unprocessed pseudogene has been assigned to 16p12-p11.2.
, carbonate dehydratase VA
, carbonic anhydrase 5, mitochondrial
, carbonic anhydrase 5A, mitochondrial
, carbonic anhydrase 5b, mitochondrial
, carbonic anhydrase VA
, carbonic anhydrase 5 mitochondrial
, carbonic anhydrase Va, mitochondrial
, carbonic anhydrase V, mitochondrial
, carbonic dehydratase