anti-Carnosine Dipeptidase 1 (Metallopeptidase M20 Family) (CNDP1) Antibodies

CNDP1 encodes a member of the M20 metalloprotease family. Additionally we are shipping Carnosine Dipeptidase 1 (Metallopeptidase M20 Family) Kits (19) and Carnosine Dipeptidase 1 (Metallopeptidase M20 Family) Proteins (18) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CNDP1 84735 Q96KN2
CNDP1 338403 Q8BUG2
CNDP1 307212 Q66HG3
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Top anti-Carnosine Dipeptidase 1 (Metallopeptidase M20 Family) Antibodies at antibodies-online.com

Showing 10 out of 103 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-CNDP1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC, IHC (p) Immunohistochemistry-Paraffin: CNDP1 Antibody [NBP1-85528] - Staining of human cerebral cortex shows moderate cytoplasmic positivity in neuronal cells. Western Blot: CNDP1 Antibody [NBP1-85528] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11.Lane 2: Human cell line RT-4.Lane 3: Human cell line U-251MG sp.Lane 4: Human plasma (IgG/HSA depleted).Lane 5: Human liver tissue.Lane 6: Human tonsil tissue 0.1 mL Log in to see 10 to 13 Days
$494.38
Details
Human Rabbit Un-conjugated EIA, FACS, IHC (p), WB CNDP1 Antibody (C-term) flow cytometry analysis of CEM cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Formalin-fixed and paraffin-embedded human brain tissue reacted with CNDP1 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated IF, WB 100 μL Log in to see 11 to 14 Days
$507.83
Details
Cow Rabbit Un-conjugated WB 50 μg Log in to see 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated WB CNDP1 Antibody (Center)  western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the CNDP1 antibody detected the CNDP1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of CNDP1 Antibody (C-term) (ABIN653113) in CEM cell line lysates (35 µg/lane). CNDP1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human brain tissue reacted with CNDP1 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Recombinant protein. Figure.DAB staining on IHC-P. Samples: Human Tissue 100 μg Log in to see 13 to 16 Days
$350.00
Details
Human Rabbit Un-conjugated WB Western blot analysis in A375 cell line lysates (35ug/lane). 400 μL Log in to see 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated ELISA, IF, IF/ICC 100 μg Log in to see 14 to 16 Days
$273.90
Details

Top referenced anti-Carnosine Dipeptidase 1 (Metallopeptidase M20 Family) Antibodies

  1. Human Polyclonal CNDP1 Primary Antibody for IHC, IHC (p) - ABIN4287941 : Peters, Kebbewar, Jansen, Jakobs, Riedl, Koeppel, Frey, Adelmann, Klingbeil, Mack, Hoffmann, Janssen, Zschocke, Yard: Relevance of allosteric conformations and homocarnosine concentration on carnosinase activity. in Amino acids 2010 (PubMed)
    Show all 5 Pubmed References

More Antibodies against Carnosine Dipeptidase 1 (Metallopeptidase M20 Family) Interaction Partners

Human Carnosine Dipeptidase 1 (Metallopeptidase M20 Family) (CNDP1) interaction partners

  1. The CNDP2 rs6566810 (A/A genotype) is overrepresented in endurance athletes, but only in international-level endurance athletes. Three SNPs (CNDP2 rs3764509, CNDP2-CNDP1 rs2346061, and CNDP1 rs2887) were overrepresented in power athletes compared with nonathletes.

  2. The distribution of the (CTG)5 homozygous genotype in the no-diabetic nephropathy (DN) and clinical-DN patients was comparable, a lower frequency was found in the biopsy proven-DN patients, particularly in females. We observed a significant trend towards high frequencies of the (CTG)5 homozygous genotype with increased time on dialysis.

  3. Considering that approximately 40 per cent of the population are homozygous for the 5L allele of (CTG) n repeat polymorphism in CNDP1 gene and seem to be less prone to develop DN, it is needed to evaluate whether the majority of diabetic patients (who do not have the 5L-5L genotype) would be benefited from supplementation with carnosine or with a more intensive monitoring

  4. Compared to healthy individuals and those with diabetes but no kidney disease, patients with diabetic nephropathy exhibited lower frequencies of 5L-5L genotype and 5L allele of CNDP1 gene, suggesting that this allele might confer protection against development of kidney disease in this population.

  5. genetic association studies in pediatric population in Germany: Data suggest that, in pediatric patients with chronic kidney disease, the nephroprotective effect of CNDP1 Mannheim genetic variant against disease progression is not restricted to patients with diabetic nephropathy.

  6. The experimentally measured higher affinity of homocarnosine for the enzyme relative to l-carnosine might be explained, at least in part, by more extensive interactions inside the monomeric and dimeric hCN1's active site.

  7. CNDP1 and CARNS are expressed in glomeruli and tubular cells; TauT is expressed in renal epithelial cells; CDNP1 may have a role in diabetic neuropathy

  8. Data shows that higher carnosine content in human skeletal muscle is positively associated with insulin resistance and fasting metabolic preference for glucose.

  9. In gastrointestinal cancer, reduced plasma levels of CNDP1 associate with signs of catabolism and poor outcome.

  10. Alterations of serum carnosinase (CN1) activity has been associated with several pathological conditions, such as neurological disorders, chronic diseases and cancer

  11. This meta-analysis confirms that the carnosinase D18S880 microsatellite polymorphism is associated with daibetic nephropathy susceptibility, especially in the type 2 DM and the Caucasian population.

  12. Rs12604675-A in CNDP1 may confer susceptibility to overt proteinuria in Japanese women with type 2 diabetes.

  13. In this review, correlations between serum carnosine and carnosinase activity and polymorphism in CNDP1 gene are analyzed. The role of CNDP1 gene polymorphism the development of diabetic nephropathy and non-diabetic chronic kidney disease is discussed.

  14. Plasma levels of FLT and S100A9 proteins are up-regulated and CNDP1 levels are down-regulated in patients with glioblastoma.

  15. Common variants in CNDP1 and CNDP2 play a role in susceptibility to kidney disease in patients with type 2 diabetes.

  16. These findings provide nominal evidence supporting a role between CNDP1 variants and diabetic kidney disease.

  17. neither CNDP1 genotype nor the normal variation in circulating testosterone levels affects the muscular carnosine content

  18. Serum histidine dipeptide concentrations are not correlated to serum carnosinase activity

  19. CNDP1 polymorphism predicts progression to ESRD in patients with diabetic nephropathies, but only late after baseline measurements.

  20. CTG polymorphism of the CNDP1 gene does not affect survival of Chinese peritoneal dialysis subjects.

Carnosine Dipeptidase 1 (Metallopeptidase M20 Family) (CNDP1) Antigen Profile

Protein Summary

This gene encodes a member of the M20 metalloprotease family. The encoded protein is specifically expressed in the brain, is a homodimeric dipeptidase which was identified as human carnosinase. This gene contains trinucleotide (CTG) repeat length polymorphism in the coding region.

Gene names and symbols associated with CNDP1

  • carnosine dipeptidase 1 (metallopeptidase M20 family) L homeolog (cndp1.L) antibody
  • carnosine dipeptidase 1 (CNDP1) antibody
  • carnosine dipeptidase 1 (metallopeptidase M20 family) (cndp1) antibody
  • carnosine dipeptidase 1 (cndp1) antibody
  • carnosine dipeptidase 1 (metallopeptidase M20 family) (Cndp1) antibody
  • carnosine dipeptidase 1 (Cndp1) antibody
  • AI746433 antibody
  • Cn1 antibody
  • CNDP1 antibody
  • CPGL2 antibody
  • HsT2308 antibody

Protein level used designations for CNDP1

carnosine dipeptidase 1 (metallopeptidase M20 family) , beta-Ala-His dipeptidase , CNDP dipeptidase 1 , carnosinase 1 , glutamate carboxypeptidase-like protein 2 , serum carnosinase

GENE ID SPECIES
398917 Xenopus laevis
421012 Gallus gallus
476165 Canis lupus familiaris
614200 Bos taurus
695195 Macaca mulatta
100061728 Equus caballus
100135225 Xenopus (Silurana) tropicalis
100172721 Pongo abelii
100554161 Anolis carolinensis
100583488 Nomascus leucogenys
84735 Homo sapiens
338403 Mus musculus
307212 Rattus norvegicus
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