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CNDP1 encodes a member of the M20 metalloprotease family.
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Human Polyclonal CNDP1 Primary Antibody for IHC, IHC (p) - ABIN4287941
Peters, Kebbewar, Jansen, Jakobs, Riedl, Koeppel, Frey, Adelmann, Klingbeil, Mack, Hoffmann, Janssen, Zschocke, Yard: Relevance of allosteric conformations and homocarnosine concentration on carnosinase activity. in Amino acids 2010
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The CNDP2 (show CNDP2 Antibodies) rs6566810 (A/A genotype) is overrepresented in endurance athletes, but only in international-level endurance athletes. Three SNPs (CNDP2 (show CNDP2 Antibodies) rs3764509, CNDP2 (show CNDP2 Antibodies)-CNDP1 rs2346061, and CNDP1 rs2887) were overrepresented in power athletes compared with nonathletes.
Considering that approximately 40 per cent of the population are homozygous for the 5L allele of (CTG) n repeat polymorphism in CNDP1 gene and seem to be less prone to develop DN, it is needed to evaluate whether the majority of diabetic patients (who do not have the 5L-5L genotype) would be benefited from supplementation with carnosine or with a more intensive monitoring
Compared to healthy individuals and those with diabetes but no kidney disease, patients with diabetic nephropathy exhibited lower frequencies of 5L-5L genotype and 5L allele of CNDP1 gene, suggesting that this allele might confer protection against development of kidney disease in this population.
genetic association studies in pediatric population in Germany: Data suggest that, in pediatric patients with chronic kidney disease, the nephroprotective effect of CNDP1 Mannheim genetic variant against disease progression is not restricted to patients with diabetic nephropathy.
The experimentally measured higher affinity of homocarnosine for the enzyme relative to l-carnosine might be explained, at least in part, by more extensive interactions inside the monomeric and dimeric hCN1 (show HCN1 Antibodies)'s active site.
CNDP1 and CARNS are expressed in glomeruli and tubular cells; TauT (show TAUT Antibodies) is expressed in renal epithelial cells; CDNP1 may have a role in diabetic neuropathy
Data shows that higher carnosine content in human skeletal muscle is positively associated with insulin (show INS Antibodies) resistance and fasting metabolic preference for glucose.
In gastrointestinal cancer, reduced plasma levels of CNDP1 associate with signs of catabolism and poor outcome.
Alterations of serum carnosinase (CN1) activity has been associated with several pathological conditions, such as neurological disorders, chronic diseases and cancer
Rs12604675-A in CNDP1 may confer susceptibility to overt proteinuria in Japanese women with type 2 diabetes.
This gene encodes a member of the M20 metalloprotease family. The encoded protein is specifically expressed in the brain, is a homodimeric dipeptidase which was identified as human carnosinase. This gene contains trinucleotide (CTG) repeat length polymorphism in the coding region.
carnosine dipeptidase 1 (metallopeptidase M20 family)
, beta-Ala-His dipeptidase
, CNDP dipeptidase 1
, carnosinase 1
, glutamate carboxypeptidase-like protein 2
, serum carnosinase