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Functional information known about COMP comes from disorders caused either by COMP mutations or, more recently, by the recognition that altered regulation of COMP contributes to disease pathology. While the mechanism(s) causing dysregulation of COMP is not known, the presence of COMP in various disease states suggest important role(s). [review]
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Adolescent idiopathic scoliosis patients had significantly high COMP promoter methylation and low gene expression. Positive and high COMP promoter methylation was correlated with young age and high Cobb angle of main curve
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Our findings indicated that hepatic stellate cells-derived COMP collaborated with CD36 and subsequently played an essential role in MEK/ERK and PI3K/AKT-mediated hepatocellular carcinoma (HCC) progression. COMP might act as a promising target for the diagnosis and treatment of aggressive HCC.
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These findings suggest that Zalpha domain of human ADAR1 binding with the GAC hairpin stem in COMP can lead to a non-genetic, RNA editing-mediated substitution in COMP that may then play a crucial role in the development of pseudoachondroplasia.
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Higher serum COMP levels in knee osteoarthritis reflect knee structural damage.
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COMP (and C-reactive protein) serum levels were both associated with the incidence of knee osteoarthritis.
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Data indicate cartilage oligomeric matrix protein (COMP) homozygote missense variant [c.1423G>A; p.(D475N)] in 2 severely affected pseudoachondroplasia individuals.
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The serum COMP is a promising biomarker in rheumatoid arthritis which reflects disease activity and damage to the articular cartilage.
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the novel mutation of COMP may result in intracellular accumulation of the mutant protein. Decreased plasma COMP and increased plasma CTX-II may potentially serve as diagnostic markers of PSACH but may not be applicable in the presymptomatic carrier.
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COMP promoted colon cancer cell proliferation partially through the activation of PI3K/ Akt/ mTOR/ p70S6K pathway.
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The findings suggest that upregulation of ADAMTS-7 and down regulation of COMP are associated with human AA.
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Data show that a rare missense variant in the COMP gene (cartilage oligomeric matrix protein) and a frameshift variant in the CHADL gene (chondroadherin-like protein) strongly associate with osteoarthritis total hip replacement.
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COMP is a novel biomarker in breast cancer, which contributes to the severity of the disease by metabolic switching and increasing invasiveness and tumor cell viability, leading to reduced survival in animal models and human patients.
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The average sCOMP level was highest among the controls and lowest among the infected children. In the juvenile idiopathic arthritis patients, the level of sCOMP was not associated with the level of CRP or with clinical signs of disease activity.
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COMT Val158Met polymorphism may influence responses to dextromethorphan (30 mg/d) by decreasing depressive symptoms in BD patients.
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The serum COMP level has the potential to be used as a biological marker for differentiating between patients with rheumatoid arthritis and healthy individuals.
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The current study expanded the mutation spectrum of the COMP gene, and contributes to the understanding of phenotype/genotype of COMPassociated diseases.
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In the absence of ultrasonographic knee cartilage deformation, the response of serum lubricin and COMP following acute vigorous exercise indicates an increase in joint lubrication and cartilage metabolism, respectively, which appears largely independent of exercise modality.
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Running appears to decrease knee intra-articular pro-inflammatory cytokine concentration and facilitates the movement of COMP from the joint space to the serum.
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Results suggest that serum oligomeric matrix protein and hyaluronic acid (COMP and HA) concentrations can be used to predict early cartilage lesions in the knee.
