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CTNND2 encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. Additionally we are shipping Catenin (Cadherin-Associated Protein), delta 2 (Neural Plakophilin-Related Arm-Repeat Protein Proteins (4) and many more products for this protein.
Showing 10 out of 61 products:
Human Monoclonal CTNND2 Primary Antibody for ELISA, WB - ABIN560530
Koutras, Lévesque: Identification of novel NPRAP/?-catenin-interacting proteins and the direct association of NPRAP with dynamin 2. in PLoS ONE 2011
delta-Catenin Regulates Spine Architecture via Cadherin and PDZ (show INADL Antibodies)-dependent Interactions.
Results conclude that the introduction of CTNND2 gene variation is an important milestone in prostate cancer metabolic adaptation.
Delta-catenin occurs in mouse brain dendrites along with PSD-95 (show DLG4 Antibodies) in postsynaptic scaffolds. It forms stable complexes with glutamate (show GRIN1 Antibodies) receptors, suggesting a link between delta-catenin and glutamatergic synaptic transmission during neuronal development.
PS-1 (show PSEN1 Antibodies) can affect delta-catenin-induced morphogenesis possibly through the regulation of its processing and stability.
conditional targeting of p120 catenin (show CTNND1 Antibodies) in mice leads to progressive development of skin neoplasias associated with intrinsic NF-kappaB (show NFKB1 Antibodies) activation.
Acute knockdown of delta-catenin leads to increases in spine and synapse density in hippocampal neurons during development.
Data provide evidence that delta-catenin may serve an important role in the malignancy of lung adenocarcinoma through activation of canonical Wnt (show WNT2 Antibodies) signaling and cancer stem cell maintenance.
Gene Ontology analysis revealed that neuronal differentiation-related genes were enriched among targets that were co-regulated by REST and TRIM28 (show TRIM28 Antibodies), while the level of CTNND2 was increased by the knockdown of REST and TRIM28 (show TRIM28 Antibodies). Consistently, during neuronal differentiation, the level of CTNND2 increased while those of REST and TRIM28 (show TRIM28 Antibodies) decreased, suggesting that CTNND2 expression may be co-regulated by both.
We propose CTNND2 as the causal gene infamilial cortical myoclonic tremor and epilepsy-3
At the molecular level, CTNND2 is at the crossroad with interactions to such signaling pathways of Wnt and Rho family small GTPases in the Ras superfamily, which are known to drive human disease pathogenesis.
Our data suggested that genetic variants in GRM6 (show GRM6 Antibodies) are associated with high myopia. The mechanism of GRM6 (show GRM6 Antibodies) in the development of high myopia need to be further investigated.
Multigenerational autosomal dominant inheritance of 5p chromosomal deletions resulting in Cri-du-Chat Syndrome with SEMA5A, CTNND2, and ICE1 deficiencies has been described.
the effect of CTNND2 polymorphisms on normal variability and identified a polymorphism (rs2561622) with significant effect on phonological ability and white matter volume in the left frontal lobe, was investigated.
Study describes two Ion-syndromic intellectual disability cases, positive for the presence of a small copy number variants, intragenic CTNND2 gene deletion.
co-expression of Delta-catenin and RhoA (show RHOA Antibodies) was significantly associated with histological type, differentiation, pTNM stage, lymphatic metastasis and a poor prognosis in non-small cell lung cancer
This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome.
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
, catenin delta-2-like
, catenin delta 2
, catenin delta-2
, neural plakophilin-related arm-repeat protein
, T-cell delta-catenin
, catenin (cadherin-associated protein), delta 2