anti-Cathepsin E (CTSE) Antibodies

Human Cathepsin E (CTSE) interaction partners

1. Cathepsin E, mitochondrial fission, and caspase activation/apoptosis are linked in the pathogenesis of pulmonary emphysema.

2. High Expression of Cathepsin E is associated with Tissues but Not Blood of Patients with Barrett's Esophagus and Adenocarcinoma.

3. Decreased activity of cathepsin E produced by decidual macrophages might be responsible for the induction of miscarriages in some recurrent miscarriage patients.

4. data demonstrate that CatE contributes to normal growth and development of mammary glands through proper trafficking and secretion of Wnt5a

5. CTSE is a marker of both gastric differentiation and signet-ring cell carcinoma, which should shed light on the mechanism of gastric tumorigenesis.

6. Cath E activity is useful as a potential molecular target for Pancreatic ductal adenocarcinoma and early detection imaging.

7. A comparative structure model of splice variant 2 was computed based on its alignment to the known structure of cathepsin E intermediate (Protein Data Bank code 1TZS) and used to rationalize its conformational properties and loss of activity.

8. Emerging roles of cathepsin E in immune system cells and skin keratinocytes, and in host defense against cancer cells.

9. Cath E selectivity was established by having -Leu**Pro- residues at the scissile peptide bond.

10. These results suggest the possible involvement of cathepsin E in disruption of the structural and functional integrity of alpha 2-macroglobulin in the endolysosome system.

11. Reduced expression of cathepsin E is observed in erythrocytes of humans with atopic dermatitis.

12. crystal structure of an activation intermediate of cathepsin E at 2.35A resolution

13. Both cathepsin E message and protein are found in human dendritic cells, but are absent in monocytes.

14. Three-dimensional structure of cathepsin-E.

15. the human cathepsin E gene is regulated by the constitutive androstane receptor

16. cathepsin E differentially regulates the nature and function of dendritic cells and macrophages

17. cathepsin E plays a substantial role in host defense against tumor cells through TRAIL-dependent apoptosis and/or tumor-associated macrophage-mediated cytotoxicity

18. CatE is important in the processing of tetanus toxin C-fragment in primary human B cells.

19. This study demonstrates the over-expression in CTSE, in particular, and TFF1 in sessile serrated adenomas compared to both hyperplastic polyps and tubular adenomas.

Mouse (Murine) Cathepsin E (CTSE) interaction partners

1. Cathepsin E, mitochondrial fission, and caspase activation/apoptosis are linked in the pathogenesis of pulmonary emphysema.

2. These results indicate that cathepsin E deficiency causes autophagy impairment concomitantly with increased aberrant mitochondria as well as increased oxidative stress.

3. impaired adipose tissue development in high fat diet-induced CatE(-/-) mice was probably due to reduced infiltration of macrophages and may lead to hepatomegaly accompanied by hepatic steatosis and hypercholesterolemia

4. L1 stimulation triggers sumoylation and cleavage of L1, thus generating the L1-70 fragment which is cleaved by cathepsin E

5. Intradermal cathepsin E has pruritogenic activity, which is at least partly mediated by the production of endothelin-1.

6. Low expression levels of MHC class II and cathepsin E might contribute to the defect in induction of Ag-specific T cells in NC mice.

7. Results suggest that Sp1 binding plays a particularly important role in the regulation of cathepsin E gene expression.

8. the findings suggest that in keratinocytes CatE is functionally linked to the expression of terminal differentiation markers, thereby regulating epidermis formation and homeostasis.

9. required for the generation of an antigenic epitope from OVA but not for the processing of Ii in microglia

10. Development of atopic dermatitis in cathepsin E-deficient mouse model is initiated by systemic accumulation of interleukin (IL)-18 and IL-1 beta, mainly due to their reduced turnover rates.

11. Cathepsin E is expressed in mice myeloid dendritic cells, where it has an important nonredundant role in the class II major histocompatibility complex antigen processing pathway.

12. cathepsin E is located in mast-cell secretory granules in complex with heparin proteoglycans, and has a role in the processing of procarboxypeptidase A into active protease

13. results indicate an essential role of cathepsin E in immune defense against invading microorganisms, most probably due to regulation of the cell surface expression of TLR family members required for innate immune responses

14. cathepsin E is important for preventing the accumulation of lysosomal membrane sialoglycoproteins that can induce a new form of lysosomal storage disorder

15. cathepsin E plays a substantial role in host defense against tumor cells through TRAIL-dependent apoptosis and/or tumor-associated macrophage-mediated cytotoxicity

16. A total of 654 genes were identified as overexpressed (>2-fold) in CatE(-/-) mammary glands.

17. Cathepsin E deficient mice are behaviorally normal when housed communally, but they become more aggressive compared with wild-type littermates when housed individually.

18. The defects in chemotaxis and cell adhesion are likely to be involved in the imperfect function of CatE(-/-)macrophages.