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STS1 encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. Additionally we are shipping Cbl-Interacting Protein Sts-1 Antibodies (26) and many more products for this protein.
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Data suggest that Sts1 (suppressor of T-cell receptor signaling-1) negatively regulates TCR (T-cell receptor) signaling in activated T-lymphocytes via dephosphorylation of ZAP70 (show ZAP70 Proteins).
The results show that the interaction between STS-1 and ShcA (show SHC1 Proteins) is regulated in response to EGF receptor (show EGFR Proteins) activation.
The study reveals a role of CBL (show CBL Proteins) in restricting myeloid proliferation of human AML1 (show RUNX1 Proteins)-ETOinduced leukemia, and identifies UBASH3B as a potential target for pharmaceutical intervention.
targeting Aurora B (show AURKB Proteins) to microtubules by UBASH3B is necessary for the timing and fidelity of chromosome segregation in human cells
These results show that TULA-2 is a target of miR (show MLXIP Proteins)-148a-3p
This recovery involves the phosphorylation of p70 (show ANXA6 Proteins) independent of mTOR (show FRAP1 Proteins).
results demonstrate the importance of STS-1 in regulating IFN-alpha (show IFNA Proteins)-induced autophagy in B cells
UBASH3B is a functional target of anti-invasive microRNA200a that is down-regulated in triple negative breast cancer. Importantly, the oncogenic potential of UBASH3B is dependent on its tyrosine phosphatase activity.
Ablation of TULA-2 resulted in hyperphosphorylation of Syk (show SYK Proteins) and its downstream effector phospholipase C (show PLC Proteins)-gamma2 as well as enhanced GPVI (show GP6 Proteins)-mediated platelet functional responses.
Sts-1 and Sts-2 (show UBASH3A Proteins) bind to Cbl (show CBL Proteins) and inhibit endocytosis of receptor tyrosine kinases
Data suggest that Sts1 (suppressor of T-cell receptor signaling-1) negatively regulates TCR (T-cell receptor) signaling in activated T-lymphocytes via dephosphorylation of Zap70 (show ZAP70 Proteins).
Sts-1 and Sts-2 (show UBASH3A Proteins) are not required for the immune control of murine herpesvirus 68 in a normal course of gammaherpesvirus infection.
The absence of TULA-2 and also the relative level of TULA-2 expression modulates FcgammaRIIA-mediated platelet reactivity and heparin-induced thrombocytopenia in vivo.
dephosphorylation of Tyr (show TYR Proteins)(P)(346) may be considered an important "checkpoint" in the regulation of Syk (show SYK Proteins) activation process. Putative biological functions of TULA-2-mediated dephosphorylation of Tyr (show TYR Proteins)(P)(346) may include deactivation of receptor-activated Syk (show SYK Proteins) or suppression of Syk (show SYK Proteins) activation by suboptimal stimulation.
Biochemical analysis identified STS-1 and STS-2 as direct phosphatases of FLT3 and c-KIT.
results demonstrate the importance of STS-1 in regulating IFN-alpha (show IFNA Proteins)-induced autophagy in B cells.
The lack of TULA-2 facilitates T-cell responses to TCR/CD3 (show CD3E Proteins) stimulation, thus exacerbating T-cell-dependent inflammation.
TULA-2 negatively regulates osteoclast differentiation and function.
Once phosphorylated, tyrosines in carboxyl terminus of protein-tyrosine kinase (show YES1 Proteins) Syk (show SYK Proteins) interact with signaling proteins, including TULA-2, a negative regulator of mast cell degranulation.
This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor.
Cbl-interacting protein Sts-1
, SH3 domain-containing 70 kDa protein, suppressor of T-cell receptor signaling 1, nm23-phosphorylated unknown substrate
, T-cell ubiquitin ligand 2
, cbl-interacting protein p70
, nm23-phosphorylated unknown substrate
, suppressor of T-cell receptor signaling 1
, tyrosine-protein phosphatase STS1/TULA2
, ubiquitin-associated and SH3 domain-containing protein B