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CDCA4 encodes a protein that belongs to the E2F family of transcription factors. Additionally we are shipping Cell Division Cycle Associated 4 Proteins (4) and and many more products for this protein.
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The results confirmed that CDCA4 RNA interference reduced the percentage of human breast cancer cells to <50%. In addition, RNA interference of CDCA4 resulted in a significant increase in the apoptotic rate of cells.
High CDCA4 expression is associated with malignant melanoma.
CDCA4 participates in the regulation of cell proliferation, mainly through the E2F/retinoblastoma protein pathway
Data suggest that CDCA4 is involved in spindle organization from prometaphase, and when anaphase begins, it may play a different role as a midzone factor involved in chromosome segregation or cytokinesis.
an important role of CDCA4 in the context of transcriptional regulation and cell fate determination through the JUN oncogene (show JUN Antibodies)
The evolutionary conservation and murine embryonic expression of the gene encoding the SERTA domain-containing protein Cdca4 was studied.
This gene encodes a protein that belongs to the E2F family of transcription factors. This protein regulates E2F-dependent transcriptional activation and cell proliferation, mainly through the E2F/retinoblastoma protein pathway. It also functions in the regulaton of JUN oncogene expression. This protein shows distinctive nuclear-mitotic apparatus distribution, it is involved in spindle organization from prometaphase, and may also play a role as a midzone factor involved in chromosome segregation or cytokinesis. Two alternatively spliced transcript variants encoding the same protein have been noted for this gene. Two pseudogenes have also been identified on chromosome 1.
cell division cycle associated 4
, cell division cycle-associated protein 4
, hematopoietic progenitor protein