anti-Ceramide Synthase 2 (CERS2) Antibodies

CERS2 encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Additionally we are shipping Ceramide Synthase 2 Kits (7) and Ceramide Synthase 2 Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CERS2 29956 Q96G23
CERS2 76893 Q924Z4
CERS2 310667  
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Top anti-Ceramide Synthase 2 Antibodies at antibodies-online.com

Showing 10 out of 63 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-LASS2 Antibody Titration:  0.2-1 ug/ml  Positive Control:  HepG2 cell lysate CERS2 is supported by BioGPS gene expression data to be expressed in HepG2 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-LASS2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  Human kidney Rabbit Anti-CERS2 Antibody   Formalin Fixed Paraffin Embedded Tissue: Human heart Tissue Observed Staining: Plasma membrane in intercalated disk Primary Antibody Concentration: 1:100 Other Working Concentrations: N/A Secondary Antibody: Donkey anti-Rabbit-Cy3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0.5 - 2.0 sec 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB Immunohistochemistry with Human kidney lysate tissue at an antibody concentration of 5.0ug/ml using anti-LASS2 antibody WB Suggested Anti-LASS2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  Human brain 100 μL Log in to see 2 to 3 Days
$289.00
Details
Guinea Pig Rabbit Un-conjugated IHC, IHC (p), WB Human Kidney (formalin-fixed, paraffin-embedded) stained with LASS2 antibody ABIN462181 followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Human Liver (formalin-fixed, paraffin-embedded) stained with LASS2 antibody ABIN462181 followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 11 to 14 Days
$727.83
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: LASS2 Antibody [NBP1-84537] Staining of human cell line A-431 shows positivity in nuclear membrane & endoplasmic reticulum. Immunohistochemistry-Paraffin: LASS2 Antibody [NBP1-84537] - Staining of human breast shows moderate cytoplasmic positivity in glandular cells. 0.1 mL Log in to see 10 to 13 Days
$491.63
Details
Fish Mouse Un-conjugated FACS, ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: LASS2 Antibody (B3-2)  - Staining LASS2 (red) in K562 cells. Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. Immunohistochemistry-Paraffin: LASS2 Antibody (B3-2)  - Analysis of paraffin-embedded human brain tissue using anti-LASS2 antibody. Counter stained with hematoxylin. 100 μL Log in to see 34 Days
$373.75
Details
Guinea Pig Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Bat Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Mouse Un-conjugated WB LASS2 monoclonal antibody (M01A), clone 1A6 Western Blot analysis of LASS2 expression in HepG2. Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (67.32 KDa) . Dilution: 1:500~1000 200 μL Log in to see 8 to 11 Days
$461.00
Details
Human Rabbit Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$390.50
Details

CERS2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Ceramide Synthase 2 Antibodies

  1. Human Monoclonal CERS2 Primary Antibody for ELISA, WB - ABIN526190 : Separovic, Breen, Joseph, Bielawski, Pierce, VAN Buren, Gudz: Ceramide synthase 6 knockdown suppresses apoptosis after photodynamic therapy in human head and neck squamous carcinoma cells. in Anticancer research 2012 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal CERS2 Primary Antibody for WB - ABIN526188 : Jensen, Calvert, Volpert, Kouri, Hurley, Luciano, Wu, Chalastanis, Futerman, Stegh: Bcl2L13 is a ceramide synthase inhibitor in glioblastoma. in Proceedings of the National Academy of Sciences of the United States of America 2014 (PubMed)

More Antibodies against Ceramide Synthase 2 Interaction Partners

Human Ceramide Synthase 2 (CERS2) interaction partners

  1. Results show that silencing of ATP6V0C (show ATP6V0C Antibodies) in highly metastatic prostate cancer (PC) cell lines, inhibited V-ATPase (show ATP6V1H Antibodies) activity, which coincided with the inhibition of cell migration and invasion in vitro, as well as a marked decrease in the expression of LASS2/TMSG1 probably through positive feedback.

  2. CerS2-knockdown via CRISPR-Cas9 technology in cultured colon epithelial cells impaired barrier function.

  3. Low expression of LASS2 and TGFB1 (show TGFB1 Antibodies) contributes to the aggressiveness and poor prognosis of hepatocellular carcinoma, and may represent a novel prognostic biomarker for hepatocellular carcinoma patients.

  4. ASGR1 (show ASGR1 Antibodies) can inhibit the activity of V-ATPase (show ATP6V1H Antibodies) by interacting with LASS2, thereby suppressing the metastatic potential of hepatoma cells.

  5. Data show that 1-acylglycerol-3-phosphate O-acyltransferase 9 (AGPAT9 (show AGPAT9 Antibodies)) inhibit cell growth by regulating expression of KLF4 (show KLF4 Antibodies)/LASS2/V-ATPase (show ATP6V1H Antibodies) proteins in breast cancer.

  6. these results indicate that miR (show MLXIP Antibodies)-9 upregulation might be associated with malignant phenotype of bladder cancer. miR (show MLXIP Antibodies)-9 promotes chemoresistance of bladder cancer cells by target LASS2.

  7. Data show that CERS2 expression was markedly different between various breast cancer cells and inversely correlated with cell invasion.

  8. silencing of TMSG1 increased V-ATPase (show ATP6V1H Antibodies) activity, decreased extracellular pH and in turn the activation of secreted MMP-2 (show MMP2 Antibodies), which ultimately promoted metastasis capacity of breast cancer cell.

  9. Results confirmed that TMSG1 is a potential metastasis suppressor gene, and suggested that the mechanism involved the induction of apoptosis and inhibition of cell proliferation via a caspase (show CASP3 Antibodies)-dependent mitochondrial pathway.

  10. the vacuolar ATPase (V-ATPase (show DNAH8 Antibodies)) activity and extracellular hydrogen ion concentration were significantly decreased and the activity of secreted matrix metalloproteinase-2 (MMP-2 (show MMP2 Antibodies)) was downregulated in MCF-7 cells overexpressing LASS2/TMSG1

Mouse (Murine) Ceramide Synthase 2 (CERS2) interaction partners

  1. Deficiency of CerS2 influences intestinal barrier function and the severity of experimental colitis and may represent a potential mechanism for inflammatory bowel disease pathogenesis.

  2. LASS2 plays an important role in efficient liver regeneration in response to partial hepatectomy.

  3. Deletion of CerS2 strongly reduced very long-chain ceramides (Cer24:0, 24:1) but concomitantly increased long-chain ceramides and sphinganine in plasma and colon tissue. In naive CerS2(-/-) mice, the expression of tight junction proteins including ZO-1 (show TJP1 Antibodies) was almost completely lost in the colon epithelium, leading to increased membrane permeability. Ceramide synthase 2 deficiency aggravates dextran induced colitis in mice.

  4. this study shows that Cers2 limits the levels of S1P (show S1PR1 Antibodies) in thymus and blood to maintain functional S1P (show S1PR1 Antibodies) gradients that mediate thymocyte emigration into the circulation

  5. that only LCBs, the substrates common for all of the CerS isoforms, but not ceramides and complex sphingolipids, were restored to the wild-type levels in the Cers2-rescued Cers1 (show CERS1 Antibodies) mutant mouse brains.

  6. CerS1 (show CERS1 Antibodies), -2, and -6 are hyperacetylated in the mitochondria of SIRT3 (show SIRT3 Antibodies)-null mice.

  7. Haploinsufficiency for this enzyme altered the pattern of ceramide acylation in the liver without affecting total ceramide levels, replacing very-long-chain ceramides with long-chain C16-ceramides.

  8. Development of pheochromocytoma in ceramide synthase 2 null mice

  9. our data strongly indicate that G-CSF (show CSF3 Antibodies)-induced CXCR2 (show CXCR2 Antibodies) expression is regulated in a CerS2-dependent manner and that CerS2 thereby promotes the migration of neutrophils, thus, contributing to inflammation and the development of EAE and MS.

  10. Data indicate that the augmented rate of death of ceramide synthase 2 (CerS2) null mice is due to elevated levels of tumor necrosis factor alpha (TNFalpha (show TNF Antibodies)) secretion as a result of enhanced activity of TNFalpha (show TNF Antibodies)-converting enzyme (TACE (show ADAM17 Antibodies)).

Ceramide Synthase 2 (CERS2) Antigen Profile

Protein Summary

This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described.

Gene names and symbols associated with CERS2

  • ceramide synthase 2 (CERS2) antibody
  • ceramide synthase 2 (Cers2) antibody
  • 0610013I17Rik antibody
  • AI225939 antibody
  • L3 antibody
  • Lass2 antibody
  • SP260 antibody
  • TMSG1 antibody
  • TRH3 antibody

Protein level used designations for CERS2

LAG1 homolog, ceramide synthase 2 , LAG1 longevity assurance 2 , longevity assurance (LAG1, S. cerevisiae) homolog 2 , tumor metastasis-suppressor gene 1 protein , LAG1 longevity assurance homolog 2 , TRAM homolog 3 , longevity assurance homolog 2 , translocating chain-associating membrane protein homolog 3

GENE ID SPECIES
100055037 Equus caballus
29956 Homo sapiens
483187 Canis lupus familiaris
539223 Bos taurus
76893 Mus musculus
310667 Rattus norvegicus
100156737 Sus scrofa
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