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Trophic factor for dopamine neurons. Additionally we are shipping CDNF Antibodies (94) and CDNF Kits (39) and many more products for this protein.
Showing 10 out of 23 products:
In various animal models of Parkinson Disease, CDNF is efficient in protecting and repairing dopaminergic neurons, and it inhibits endoplasmic reticulum stress, euroinflammation, and apoptosis.
The results showed that AAV8-CDNF administration significantly improved the motor function and increased the tyrosine hydroxylase (TH (show TH Proteins)) levels in Parkinson's disease rats with mild lesions (2 weeks post lesion), but it had limited therapeutic effects in rats with severe lesions (5 weeks post lesion).
Results suggest that CDNF treatment selectively enhances long-term memory consolidation
showed that CDNF was able to protect dopaminergic neurons against injury caused by alpha-synuclein oligomers. This advises its use against physiological damages caused by alpha-synuclein oligomers
Expression of CDNF in the substantia nigra has an anti-inflammatory effect on experimental Parkinson's disease.
Although no CDNF mutations are found in early-onset Parkinson's disease patient samples, a trend towards increased risk for Parkinson's in carriers of the C allele of rs7094179 single nucleotide polymorphism (SNP) is found.
expressed in several tissues; might be beneficial for the treatment of Parkinson's disease
structures of MANF (show MANF Proteins) and CDNF were solved; structure explains why MANF (show MANF Proteins) and CDNF are bifunctional; neurotrophic activity may reside in the N-terminal domain and ER stress response in the C-terminal domain
Study suggests that there is no association between variants in the CDNF gene and cocaine dependence.
secretion of mouse MANF (show MANF Proteins) and mouse CDNF is fundamentally regulated in the same manner, the variation of four C-terminal amino acids in the MANF (show MANF Proteins) and CDNF among species might influence their intracellular functions.
This study demonstrated that decrease in mRNA level of CDNF in brain in microgravity.
CDNF (Armetl1) is expressed in several tissues, including the mouse embryonic and postnatal brain
Trophic factor for dopamine neurons. Prevents the 6- hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra.
ARMET-like protein 1
, arginine-rich, mutated in early stage tumors-like 1
, conserved dopamine neurotrophic factor
, arginine-rich protein mutated in early stage tumors-like 1