CHFR Proteins

E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons.

Data Quality
  • 5
Type
  • 5
    Protein
Antigen
  • 5
Reactivity
  • 4
  • 1
Application
  • 4
  • 4
  • 2
  • 2
  • 2
Host
  • 2
  • 2
  • 1
Binding Specificity
  • 2
  • 1
  • 1
  • 1
Conjugate
  • 2
  • 2
  • 1
Protein Type
  • 5
Format
  • 2
5 Products
Recombinant Protein, Insect Cells (Source), Purity >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ReactivityHuman
Application Crys, ELISA, SDS, WB
Order details Cat. No. ABIN3091433
$9,371.15
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 60 Business Days
Recombinant Protein, Insect Cells (Source), Purity >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ReactivityMouse (Murine)
Application Crys, ELISA, SDS, WB
Order details Cat. No. ABIN3136097
$9,371.15
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 60 Business Days
ReactivityHuman
Application AA, AP, ELISA, WB
Order details Cat. No. ABIN1349312
$414.29
Plus shipping costs $45.00 and $22.00 dry ice
Delivery in 11 to 12 Business Days
ReactivityHuman
Application AA, AP, ELISA, WB
Order details Cat. No. ABIN1349314
$414.29
Plus shipping costs $45.00 and $22.00 dry ice
Delivery in 11 to 12 Business Days
Recombinant Protein, HEK-293 Cells (Source), Purity > 80 % as determined by SDS-PAGE and Coomassie blue staining
ReactivityHuman
Application AbP, Func, PI, STD
Order details Cat. No. ABIN2713969
$932.80
20 μg
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 11 Business Days
  • <
  • 1
  • >

CHFR Protein Profile

Protein Summary

E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating ubc13-mms2 (ube2n-ube2v2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress (By similarity).

Gene names and symbols associated with CHFR

  • checkpoint with forkhead and ring finger domains (CHFR) antibody
  • checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase (chfr) antibody
  • checkpoint with forkhead and ring finger domains (Chfr) antibody
  • checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase L homeolog (chfr.L) antibody
  • 5730484M20Rik antibody
  • C230082M18 antibody
  • CHFR antibody
  • rnf116 antibody
  • rnf196 antibody

Protein level used designations for CHFR

E3 ubiquitin-protein ligase CHFR , RING finger protein 196 , checkpoint with forkhead and RING finger domains protein , checkpoint with forkhead and ring finger domains , e3 ubiquitin-protein ligase CHFR-like

GENE ID SPECIES
55743 Homo sapiens
416792 Gallus gallus
694297 Macaca mulatta
395009 Xenopus (Silurana) tropicalis
231600 Mus musculus
100355591 Oryctolagus cuniculus
100467000 Ailuropoda melanoleuca
734287 Xenopus laevis