anti-Chemokine (C-C Motif) Receptor 4 (CCR4) Antibodies

The protein encoded by CCR4 belongs to the G-protein-coupled receptor family .

list all antibodies Gene Name GeneID UniProt
Anti-Human CCR4 CCR4 1233 P51679
Anti-Mouse CCR4 CCR4 12773 P51680
Anti-Rat CCR4 CCR4 171054  
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Top anti-CCR4 Antibodies at antibodies-online.com

Showing 10 out of 226 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Biotin FACS   0.5 mg Log in to see 15 to 18 Days
$504.51
Details
Human Mouse Un-conjugated FACS   0.1 mg Log in to see 15 to 18 Days
$223.82
Details
Human Mouse Un-conjugated CyTOF, FACS Detection of CCR4 in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human CD4 APC-conjugated Monoclonal Antibody. 100 μg Log in to see 8 to 9 Days
$346.15
Details
Human Mouse PE FACS Detection of CCR4 in Rat Peripheral Blood Cells by Flow Cytometry. Rat peripheral blood cells were stained with Mouse Anti-Human/Rat CCR4 PE-conjugated Monoclonal Antibody. Detection of CCR4 in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human CD3 epsilon APC-conjugated Monoclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$363.40
Details
Human Mouse Fluorescein FACS Detection of CCR4 in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human/Rat CCR4 Fluorescein-conjugated Monoclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$299.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-CCR4 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  721_B cell lysate CCR4 is supported by BioGPS gene expression data to be expressed in 721_B 100 μL Log in to see 2 to 3 Days
$289.00
Details
Dog Rabbit Un-conjugated WB Western blot analysis of CCR4 expression in HEK293T (A), NIH3T3 (B) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Cow Rabbit Un-conjugated WB Western blot analysis of CCR4 expression in HL60 (A), MCF7 (B) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Goat Un-conjugated ICC, FACS, IHC (fro), IF, IHC (p), IHC, ELISA, WB Immunohistochemistry on paraffin section of human spleen 0.1 mg Log in to see 8 to 11 Days
$415.44
Details
Human Mouse APC FACS Detection of CCR4 in Rat Splenocytes by Flow Cytometry. Rat splenocytes were stained with Mouse Anti-Human/Rat CCR4 APC-conjugated Monoclonal Antibody. Detection of CCR4 in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human CD3 epsilon PE-conjugated Monoclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$416.30
Details

Top referenced anti-CCR4 Antibodies

  1. Human Monoclonal CCR4 Primary Antibody for CyTOF, FACS - ABIN4899090 : Aruga, Takeshita, Kotera, Okuyama, Matsushita, Ohta, Takeda, Yamamoto: Long-term Vaccination with Multiple Peptides Derived from Cancer-Testis Antigens Can Maintain a Specific T-cell Response and Achieve Disease Stability in Advanced Biliary Tract Cancer. in Clinical cancer research : an official journal of the American Association for Cancer Research 2013 (PubMed)
    Show all 12 Pubmed References

  2. Human Monoclonal CCR4 Primary Antibody for FACS - ABIN4895505 : Aruga, Takeshita, Kotera, Okuyama, Matsushita, Ohta, Takeda, Yamamoto: Phase I clinical trial of multiple-peptide vaccination for patients with advanced biliary tract cancer. in Journal of translational medicine 2014 (PubMed)
    Show all 11 Pubmed References

  3. Human Monoclonal CCR4 Primary Antibody for FACS - ABIN2689051 : Bonecchi, Bianchi, Bordignon, DAmbrosio, Lang, Borsatti, Sozzani, Allavena, Gray, Mantovani, Sinigaglia: Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. in The Journal of experimental medicine 1998 (PubMed)
    Show all 9 Pubmed References

  4. Human Monoclonal CCR4 Primary Antibody for FACS - ABIN2689052 : Campbell, Haraldsen, Pan, Rottman, Qin, Ponath, Andrew, Warnke, Ruffing, Kassam, Wu, Butcher: The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells. in Nature 1999 (PubMed)
    Show all 7 Pubmed References

  5. Human Monoclonal CCR4 Primary Antibody for FACS - ABIN4895502 : James, Gates, LaFond, Yamamoto, Ni, Mai, Gersuk, OBrien, Nguyen, Zeitner, Lanteri, Norris, Chaussabel, Malhotra, Kwok: Neuroinvasive West Nile Infection Elicits Elevated and Atypically Polarized T Cell Responses That Promote a Pathogenic Outcome. in PLoS pathogens 2016 (PubMed)
    Show all 7 Pubmed References

  6. Human Polyclonal CCR4 Primary Antibody for ICC, FACS - ABIN152140 : Power, Meyer, Nemeth, Bacon, Hoogewerf, Proudfoot, Wells: Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line. in The Journal of biological chemistry 1995 (PubMed)
    Show all 6 Pubmed References

  7. Human Monoclonal CCR4 Primary Antibody for FACS - ABIN4895498 : Antonelli, Mahnke, Hodge, Porter, Barber, DerSimonian, Greenwald, Roby, Mican, Sher, Roederer, Sereti: Elevated frequencies of highly activated CD4+ T cells in HIV+ patients developing immune reconstitution inflammatory syndrome. in Blood 2010 (PubMed)
    Show all 3 Pubmed References

  8. Human Polyclonal CCR4 Primary Antibody for WB - ABIN4289060 : Park, Roh, Kim, Kim, Han, Hong: CCR5 plays an important role in resolving an inflammatory response to single-walled carbon nanotubes. in Journal of applied toxicology : JAT 2013 (PubMed)
    Show all 3 Pubmed References

  9. Human Polyclonal CCR4 Primary Antibody for IF (p), IHC (p) - ABIN738666 : Ge, Li, Jiang, You, Liu, Zhong, Huang, Xing: Integration of nondegradable polystyrene and degradable gelatin in a core-sheath nanofibrous patch for pelvic reconstruction. in International journal of nanomedicine 2015 (PubMed)

  10. Mouse (Murine) Polyclonal CCR4 Primary Antibody for ICC, FACS - ABIN152144 : Herling, Patel, Weit, Lilienthal, Hallek, Keating, Jones: High TCL1 levels are a marker of B-cell receptor pathway responsiveness and adverse outcome in chronic lymphocytic leukemia. in Blood 2009 (PubMed)

More Antibodies against CCR4 Interaction Partners

Human Chemokine (C-C Motif) Receptor 4 (CCR4) interaction partners

  1. the expression of chemokine (show CCL1 Antibodies) receptors in different peripheral blood T-cell subsets in patients with polymyositis (PM) and dermatomyositis, was examined.

  2. This review presents key clinical studies of Multiple sclerosis together with experimental studies in animals that have demonstrated functional roles of CCR4, CCL17 (show CCL17 Antibodies), and CCL22 (show CCL22 Antibodies) in experimental autoimmune encephalomyelitis pathogenesis. [review]

  3. Taken together, our data showed a likely positive feedback mechanism of enhanced IL-6 (show IL6 Antibodies) production in ectopic milieu. The high levels of IL-6 (show IL6 Antibodies) in the peritoneal cavity stimulate the expression of CCL17 (show CCL17 Antibodies) in endometrial stromal cells by activating JNK (show MAPK8 Antibodies) signal pathway, and then, CCL17 (show CCL17 Antibodies) further induces CCR4 expression on macrophages, which eventually leads to an increase in IL-6 (show IL6 Antibodies) production via NF-kappaB (show NFKB1 Antibodies) activation.

  4. Investigations showed that the level of CCR4 could be induced by TNF-alpha (show TNF Antibodies) dependent of NF-kappaB (show NFKB1 Antibodies) activation in CRC (show CALR Antibodies) cells. CCR4 might be implicated in TNF-alpha (show TNF Antibodies)-regulated cancer cells metastasis.

  5. Tumor-associated macrophages promote prostate cancer migration through activation of the CCL22 (show CCL22 Antibodies)-CCR4 signaling axis.

  6. monocyte chemoattractant protein-1 (MCP-1 (show CCL2 Antibodies)), an endogenous CCR4-binding ligand, was specifically upregulated in the head and neck squamous cell carcinomamicroenvironment compared to the other four CCR4-binding ligands

  7. Chemokine (show CCL1 Antibodies) receptors CCR3 (show CCR3 Antibodies) and CCR4, and the mucosa specific chemokine (show CCL1 Antibodies) CCL28 (show ENC1 Antibodies) have predominant roles in oral wound healing by increasing human gingiva fibroblast proliferation, migration, and the secretion of IL-6 (show IL6 Antibodies) and HGF (show HGF Antibodies) and reducing the secretion of TIMP-1 (show TIMP1 Antibodies).

  8. A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer

  9. The percentage of CXCR3 (show CXCR3 Antibodies)(+) CD4 (show CD4 Antibodies)(+) TEM (show CYLD Antibodies) cells negatively correlated with the severity of the cutaneous disease in psoriasis patients. Importantly CLA (show SELPLG Antibodies)(+) CD4 (show CD4 Antibodies)(+) TCM cells expressing CCR6 (show CCR6 Antibodies)(+) or CCR4(+)CXCR3 (show CXCR3 Antibodies)(+) negatively correlated with psoriasis severity suggesting recruitment to the skin compartment.

  10. Case Report: CCR4+ T-cell depletion by mogamulizumab treatment of adult T-cell leukaemia/lymphoma results in CD8 (show CD8A Antibodies)-positive T-cell mediated dermatitis.

Mouse (Murine) Chemokine (C-C Motif) Receptor 4 (CCR4) interaction partners

  1. data demonstrate a mechanistic or developmental role of CCR4 in the regulation of locomotor and exploratory behaviors

  2. A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer

  3. CCR4 is critically involved in regional lymph node dendritic cell-Th17 cell interactions that are necessary for Th17 cell-mediated induction of antitumor CD8 (show CD8A Antibodies)+ effector T cells in mice bearing B16 melanoma.

  4. CCR4 is involved in immunosuppression after severe sepsis and suggest that CCR4+ Regulatory T Cells negatively modulate the short and long-term immune responses.

  5. CCL22 (show CCL22 Antibodies) was localised mainly on the cell surface and or in the cytoplasm. Within sections of omental milky spot micrometastases, CCR4 was recognised on or in gastric cancer cells, constituent cells milky spots, blood cells and blood endothelial cells

  6. CCR4 is involved in regulating negative selection of polyclonal and T cell receptor (TCR) transgenic thymocytes

  7. results show that the IL-4 (show IL4 Antibodies)/CCL22 (show CCL22 Antibodies)/CCR4 axis is involved in the migration of Tregs to osteolytic lesion sites, and attenuates development of lesions by inhibiting inflammatory migration and the production of proinflammatory and osteoclastogenic mediators

  8. These data have uncovered a novel role of core components of the Ccr4-Not complex as regulators of transition from partial to genuine induced pluripotent stem cells.

  9. that effective engagement of CCR4 by CCL17 (show CCL17 Antibodies) involves two distinct binding domains and interaction with both is required for signaling

  10. NF-kappaB (show NFKB1 Antibodies) signaling pathway was involved in the asthmatic change induced by CKLF1, among which CCR4 might play a crucial role

CCR4 Antigen Profile

Protein Summary

The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis.

Gene names and symbols associated with CCR4

  • C-C motif chemokine receptor 4 (CCR4) antibody
  • C-C motif chemokine receptor 4 (Ccr4) antibody
  • chemokine (C-C motif) receptor 4 (Ccr4) antibody
  • C-C CKR-4 antibody
  • CC-CKR-4 antibody
  • Ccr4 antibody
  • CD194 antibody
  • CHEMR1 antibody
  • ChemR13 antibody
  • CKR4 antibody
  • Cmkbr4 antibody
  • HGCN:14099 antibody
  • K5-5 antibody
  • LESTR antibody
  • Sdf1r antibody

Protein level used designations for CCR4

C-C CKR-4 , C-C chemokine receptor type 4 , CCR-4 , chemokine (C-C) receptor 4 , chemokine (C-C motif) receptor 4 , C-C chemokine receptor type 4-like , c-C chemokine receptor type 4-like , nocturnin , CC-chemokine receptor 4 , fusin , leukocyte-expressed seven-transmembrane-domain receptor , CC chemokine receptor 4 , CC-CKR-4 , C-C chemokine receptor 4

GENE ID SPECIES
1233 Homo sapiens
100397096 Callithrix jacchus
100445664 Pongo abelii
100585668 Nomascus leucogenys
100379615 Cavia porcellus
12773 Mus musculus
403541 Canis lupus familiaris
408019 Bos taurus
171054 Rattus norvegicus
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