Chemokine (C-C Motif) Receptor 4 Proteins (CCR4)

The protein encoded by CCR4 belongs to the G-protein-coupled receptor family . Additionally we are shipping CCR4 Antibodies (218) and CCR4 Kits (28) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CCR4 1233 P51679
CCR4 12773 P51680
CCR4 171054  
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Top CCR4 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$7,493.38
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$5,262.31
Details
Wheat germ Human Un-conjugated   2 μg Log in to see 11 to 12 Days
$491.43
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Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days
$625.39
Details
Escherichia coli (E. coli) Cat Un-conjugated   5 applications Log in to see 1 to 2 Days
$318.85
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CCR4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,

Mouse (Murine) ,

Rat (Rattus)

More Proteins for Chemokine (C-C Motif) Receptor 4 (CCR4) Interaction Partners

Human Chemokine (C-C Motif) Receptor 4 (CCR4) interaction partners

  1. MACs from Familial hypercholesterolemia (FH)-MACs have an inflammatory phenotype that is characterized by the up-regulation of CCR3, CCR4, and CXCR1 under the control of miR-505-3p. These results suggest a chronic inflammatory condition in FH innate immunity cells that is not reverted by standard lipid-lowering treatment

  2. the expression of chemokine receptors in different peripheral blood T-cell subsets in patients with polymyositis (PM) and dermatomyositis, was examined.

  3. This review presents key clinical studies of Multiple sclerosis together with experimental studies in animals that have demonstrated functional roles of CCR4, CCL17, and CCL22 in experimental autoimmune encephalomyelitis pathogenesis. [review]

  4. Taken together, our data showed a likely positive feedback mechanism of enhanced IL-6 production in ectopic milieu. The high levels of IL-6 in the peritoneal cavity stimulate the expression of CCL17 in endometrial stromal cells by activating JNK signal pathway, and then, CCL17 further induces CCR4 expression on macrophages, which eventually leads to an increase in IL-6 production via NF-kappaB activation.

  5. Investigations showed that the level of CCR4 could be induced by TNF-alpha dependent of NF-kappaB activation in CRC cells. CCR4 might be implicated in TNF-alpha-regulated cancer cells metastasis.

  6. Tumor-associated macrophages promote prostate cancer migration through activation of the CCL22-CCR4 signaling axis.

  7. monocyte chemoattractant protein-1 (MCP-1), an endogenous CCR4-binding ligand, was specifically upregulated in the head and neck squamous cell carcinomamicroenvironment compared to the other four CCR4-binding ligands

  8. Chemokine receptors CCR3 and CCR4, and the mucosa specific chemokine CCL28 have predominant roles in oral wound healing by increasing human gingiva fibroblast proliferation, migration, and the secretion of IL-6 and HGF and reducing the secretion of TIMP-1.

  9. A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer

  10. The percentage of CXCR3(+) CD4(+) TEM cells negatively correlated with the severity of the cutaneous disease in psoriasis patients. Importantly CLA(+) CD4(+) TCM cells expressing CCR6(+) or CCR4(+)CXCR3(+) negatively correlated with psoriasis severity suggesting recruitment to the skin compartment.

  11. Case Report: CCR4+ T-cell depletion by mogamulizumab treatment of adult T-cell leukaemia/lymphoma results in CD8-positive T-cell mediated dermatitis.

  12. CCL22-specific antibodies reveal that engagement of two distinct binding domains on CCL22 is required for CCR4-mediated function.

  13. CCR4 mutation is an important determinant of the clinical course in ATLL cases, and that NS and FS mutations of CCR4 behave differently with respect to ATLL pathophysiology.

  14. Distinctive Treg associated CCR4-CCL22 expression profile with altered frequency of Th17/Treg cell in the immunopathogenesis of Pemphigus Vulgaris.

  15. Data show that CCR4 was over-expressed in lymph node-negative human gastric cancer tissues and suggest its involvement in promoting tumor invasion probably, through up-regulation of MMP9.

  16. CCR4 C1014T and CCL22 C16A genetic variations were neither associated with the risk, nor with the progression of colorectal cancer in Iranian population

  17. Higher percentages of CCR4+ CD4 TEM cells in acute RSV infection were accompanied with higher percentages of CXCR3+ CD8 TEM cells, whereas the development of long-lived memory CXCR3+ CD4 and CD8 TCM cells seems to be compromised

  18. These findings implicate somatic gain-of-function CCR4 mutations in the pathogenesis of adult T cell leukemia/lymphoma.

  19. CCR4 has a role in tumor aggressive behavior in renal cell carcinoma

  20. Data show that CCR4 exists in at least two distinct conformations, which are differentially activated by ligand.

Mouse (Murine) Chemokine (C-C Motif) Receptor 4 (CCR4) interaction partners

  1. data demonstrate a mechanistic or developmental role of CCR4 in the regulation of locomotor and exploratory behaviors

  2. A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer

  3. CCR4 is critically involved in regional lymph node dendritic cell-Th17 cell interactions that are necessary for Th17 cell-mediated induction of antitumor CD8+ effector T cells in mice bearing B16 melanoma.

  4. CCR4 is involved in immunosuppression after severe sepsis and suggest that CCR4+ Regulatory T Cells negatively modulate the short and long-term immune responses.

  5. CCL22 was localised mainly on the cell surface and or in the cytoplasm. Within sections of omental milky spot micrometastases, CCR4 was recognised on or in gastric cancer cells, constituent cells milky spots, blood cells and blood endothelial cells

  6. CCR4 is involved in regulating negative selection of polyclonal and T cell receptor (TCR) transgenic thymocytes

  7. results show that the IL-4/CCL22/CCR4 axis is involved in the migration of Tregs to osteolytic lesion sites, and attenuates development of lesions by inhibiting inflammatory migration and the production of proinflammatory and osteoclastogenic mediators

  8. These data have uncovered a novel role of core components of the Ccr4-Not complex as regulators of transition from partial to genuine induced pluripotent stem cells.

  9. that effective engagement of CCR4 by CCL17 involves two distinct binding domains and interaction with both is required for signaling

  10. NF-kappaB signaling pathway was involved in the asthmatic change induced by CKLF1, among which CCR4 might play a crucial role

  11. CCR4-expressing Th2cells play a critical role in the pathogenesis of bronchial asthma by producing Th2 cytokines.

  12. CCR4 promotes natural killer cell priming/activation by mediating contacts with sentinel cells in the lung.

  13. Combining a panel of thymocyte maturation markers with cell surface analysis of CCR7 and CCR4 identifies distinct stages in the development of multiple alphabetaT cell lineages in the adult thymus.

  14. CCR4 and CXCR3 play different roles in the migration of T cells to inflammation in skin, arthritic joints, and lymph nodes.

  15. lung dendritic cells imprint T cell lung homing and promote lung immunity in part through CCR4.

  16. CCR4-deficient mice have a more rapid progression of experimental autoimmune encephalomyelitis.

  17. CCR4.exacerbated allergic inflammation of CCR4KO mice was directly associated with an impaired migration of regulatory (Treg) cells to airways and augmented frequency of pulmonary T helper (Th)2 cells.

  18. CCR4 plays an important role in T reg cell trafficking in lymph nodes and that this is critical for T reg cell suppressive function in inflammatory bowel disease.

  19. CCR4 is not T helper (Th) type 2 cell-restricted and is required for sustenance and expression of the Th1 effector/memory response to mycobacterial antigens.

  20. CC chemokine receptor 4 is required for experimental autoimmune encephalomyelitis by regulating GM-CSF and IL-23 production in dendritic cells

CCR4 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis.

Gene names and symbols associated with CCR4

  • C-C motif chemokine receptor 4 (CCR4)
  • C-C motif chemokine receptor 4 (Ccr4)
  • chemokine (C-C motif) receptor 4 (Ccr4)
  • C-C CKR-4 protein
  • CC-CKR-4 protein
  • Ccr4 protein
  • CD194 protein
  • CHEMR1 protein
  • ChemR13 protein
  • CKR4 protein
  • Cmkbr4 protein
  • HGCN:14099 protein
  • K5-5 protein
  • LESTR protein
  • Sdf1r protein

Protein level used designations for CCR4

C-C CKR-4 , C-C chemokine receptor type 4 , CCR-4 , chemokine (C-C) receptor 4 , chemokine (C-C motif) receptor 4 , C-C chemokine receptor type 4-like , c-C chemokine receptor type 4-like , nocturnin , CC-chemokine receptor 4 , fusin , leukocyte-expressed seven-transmembrane-domain receptor , CC chemokine receptor 4 , CC-CKR-4 , C-C chemokine receptor 4

GENE ID SPECIES
1233 Homo sapiens
100397096 Callithrix jacchus
100445664 Pongo abelii
100585668 Nomascus leucogenys
100379615 Cavia porcellus
12773 Mus musculus
403541 Canis lupus familiaris
408019 Bos taurus
171054 Rattus norvegicus
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