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The protein encoded by CCR4 belongs to the G-protein-coupled receptor family . Additionally we are shipping CCR4 Antibodies (218) and CCR4 Kits (28) and many more products for this protein.
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MACs from Familial hypercholesterolemia (FH)-MACs have an inflammatory phenotype that is characterized by the up-regulation of CCR3 (show CCR3 Proteins), CCR4, and CXCR1 (show CXCR1 Proteins) under the control of miR (show MLXIP Proteins)-505-3p. These results suggest a chronic inflammatory condition in FH innate immunity cells that is not reverted by standard lipid-lowering treatment
the expression of chemokine (show CCL1 Proteins) receptors in different peripheral blood T-cell subsets in patients with polymyositis (PM) and dermatomyositis, was examined.
This review presents key clinical studies of Multiple sclerosis together with experimental studies in animals that have demonstrated functional roles of CCR4, CCL17 (show CCL17 Proteins), and CCL22 (show CCL22 Proteins) in experimental autoimmune encephalomyelitis pathogenesis. [review]
Taken together, our data showed a likely positive feedback mechanism of enhanced IL-6 (show IL6 Proteins) production in ectopic milieu. The high levels of IL-6 (show IL6 Proteins) in the peritoneal cavity stimulate the expression of CCL17 (show CCL17 Proteins) in endometrial stromal cells by activating JNK (show MAPK8 Proteins) signal pathway, and then, CCL17 (show CCL17 Proteins) further induces CCR4 expression on macrophages, which eventually leads to an increase in IL-6 (show IL6 Proteins) production via NF-kappaB (show NFKB1 Proteins) activation.
Investigations showed that the level of CCR4 could be induced by TNF-alpha (show TNF Proteins) dependent of NF-kappaB (show NFKB1 Proteins) activation in CRC (show CALR Proteins) cells. CCR4 might be implicated in TNF-alpha (show TNF Proteins)-regulated cancer cells metastasis.
Tumor-associated macrophages promote prostate cancer migration through activation of the CCL22 (show CCL22 Proteins)-CCR4 signaling axis.
monocyte chemoattractant protein-1 (MCP-1 (show CCL2 Proteins)), an endogenous CCR4-binding ligand, was specifically upregulated in the head and neck squamous cell carcinomamicroenvironment compared to the other four CCR4-binding ligands
Chemokine (show CCL1 Proteins) receptors CCR3 (show CCR3 Proteins) and CCR4, and the mucosa specific chemokine (show CCL1 Proteins) CCL28 (show ENC1 Proteins) have predominant roles in oral wound healing by increasing human gingiva fibroblast proliferation, migration, and the secretion of IL-6 (show IL6 Proteins) and HGF (show HGF Proteins) and reducing the secretion of TIMP-1 (show TIMP1 Proteins).
A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer
The percentage of CXCR3 (show CXCR3 Proteins)(+) CD4 (show CD4 Proteins)(+) TEM (show CYLD Proteins) cells negatively correlated with the severity of the cutaneous disease in psoriasis patients. Importantly CLA (show SELPLG Proteins)(+) CD4 (show CD4 Proteins)(+) TCM cells expressing CCR6 (show CCR6 Proteins)(+) or CCR4(+)CXCR3 (show CXCR3 Proteins)(+) negatively correlated with psoriasis severity suggesting recruitment to the skin compartment.
data demonstrate a mechanistic or developmental role of CCR4 in the regulation of locomotor and exploratory behaviors
CCR4 is critically involved in regional lymph node dendritic cell-Th17 cell interactions that are necessary for Th17 cell-mediated induction of antitumor CD8 (show CD8A Proteins)+ effector T cells in mice bearing B16 melanoma.
CCR4 is involved in immunosuppression after severe sepsis and suggest that CCR4+ Regulatory T Cells negatively modulate the short and long-term immune responses.
CCL22 (show CCL22 Proteins) was localised mainly on the cell surface and or in the cytoplasm. Within sections of omental milky spot micrometastases, CCR4 was recognised on or in gastric cancer cells, constituent cells milky spots, blood cells and blood endothelial cells
CCR4 is involved in regulating negative selection of polyclonal and T cell receptor (TCR) transgenic thymocytes
results show that the IL-4 (show IL4 Proteins)/CCL22 (show CCL22 Proteins)/CCR4 axis is involved in the migration of Tregs to osteolytic lesion sites, and attenuates development of lesions by inhibiting inflammatory migration and the production of proinflammatory and osteoclastogenic mediators
These data have uncovered a novel role of core components of the Ccr4-Not complex as regulators of transition from partial to genuine induced pluripotent stem cells.
that effective engagement of CCR4 by CCL17 (show CCL17 Proteins) involves two distinct binding domains and interaction with both is required for signaling
NF-kappaB (show NFKB1 Proteins) signaling pathway was involved in the asthmatic change induced by CKLF1, among which CCR4 might play a crucial role
The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis.
, C-C chemokine receptor type 4
, chemokine (C-C) receptor 4
, chemokine (C-C motif) receptor 4
, C-C chemokine receptor type 4-like
, c-C chemokine receptor type 4-like
, CC-chemokine receptor 4
, leukocyte-expressed seven-transmembrane-domain receptor
, CC chemokine receptor 4
, C-C chemokine receptor 4