anti-Chibby Homolog 1 (Drosophila) (CBY1) Antibodies

Xenopus laevis Chibby Homolog 1 (Drosophila) (CBY1) interaction partners

1. Chibby functions in Xenopus ciliary assembly, embryonic development, and the regulation of gene expression.

Human Chibby Homolog 1 (Drosophila) (CBY1) interaction partners

1. Our study reveals an association between Chibby expression and cancer aerobic glycolysis, which highlights the importance of Wnt/beta-catenin pathway in regulation of energy metabolism of NPC. These results indicate that Chibby and PDK1 are the potential target for NPC treatment.

2. FAM92 proteins interact with Cby1 to promote ciliogenesis via regulation of membrane-remodeling processes.

3. chronic Cby1 knockdown in colon cancer cells may counteract tumor progression by promoting the mesenchymal-to-epithelial transition process.

4. Cby's C-terminal domain alone binds to TC-1 with significantly greater affinity compared to full-length Cby, implying that target binding of the coiled-coil domain is affected by the flanking disordered regions.

5. CBY1 downregulation in CML comes from reduced protein stability when bound to 14-3-3sigma adapter protein. Dissociation raises CBY1 protein levels by enhancing its stability. The ubiquitin proteasome system reduces 14-3-3sigma-bound CBY1 stability by SUMOylation.

6. Results show the hypermethylation of CBY1 and BCL2-like11 promoters proceeding from DNMT1 is a crucial component of their reduced expression, but it is not directly involved in chronic myeloid leukemia resistance to imatinib.

7. Study showed that expression of Cby protein was strongly downregulated in laryngeal squamous cell carcinoma (LSCC) tumor tissues in comparison to normal laryngeal mucosa samples.

8. the impact of BCR-ABL1 on Chibby1, a beta catenin antagonist involved in cell differentiation and transformation

9. Stable expression of CBY1 drives beta catenin cytoplasmatic translocation and impairs beta catenin signaling in BCR-ABL + cells.

10. Results from the association analysis suggest that common variation in CBY is not a cause for obesity in the Belgian population.

11. C-terminal polycystin-2 influences the interaction with PIGEA14

12. Cby plays an important role in organization of both primary and motile cilia in collaboration with Cnx.

13. The N-terminal portion of the CBY1 is unstructured in solution, but the C-terminal half forms a coiled-coil structure.

14. Chibby and clusterin were co-immunoprecipitated with NBPF1.

15. These findings unravel the molecular basis through which a combinatorial action of Cby and 14-3-3 proteins controls the dynamic nuclear-cytoplasmic trafficking of beta-catenin.

16. Chibby inhibits beta-catenin-mediated transcriptional activation by competing with Lef-1 to bind to beta-catenin

17. PIGEA-14 plays an important role in regulating the intracellular location of polycystin-2

18. As no somatic mutation was detected in C22orf2 in 36 colorectal tumour DNA, our results do not support the implication of Chibby as a tumour suppressor in colorectal carcinogenesis.

19. Chibby is not likely to promote colorectal carcinoma tumor development or progression.

20. CBY promotes adipocyte differentiation through inhibition of beta catenin signaling.

Mouse (Murine) Chibby Homolog 1 (Drosophila) (CBY1) interaction partners

1. FAM92 proteins interact with Cby1 to promote ciliogenesis via regulation of membrane-remodeling processes.

2. Cby1 is required for efficient recruitment of Ahi1, providing a possible molecular mechanism for the ciliogenesis defect in Cby1(-/-) cells.