anti-Chimerin (Chimaerin) 2 (CHN2) Antibodies

Mouse (Murine) Chimerin (Chimaerin) 2 (CHN2) interaction partners

1. our data redefine the role of beta2-chimaerin as tumor suppressor and provide the first in vivo evidence of a dual function in breast cancer, suppressing tumor initiation but favoring tumor progression.

2. Study demonstrates that Sema3F-dependent inhibition of Rac1 by the Rac-GAP beta2Chn is required for hippocampal infrapyramidal tract pruning.

3. the Rac-GAP beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated phosphorylation

Human Chimerin (Chimaerin) 2 (CHN2) interaction partners

1. our data redefine the role of beta2-chimaerin as tumor suppressor and provide the first in vivo evidence of a dual function in breast cancer, suppressing tumor initiation but favoring tumor progression.

2. this study shows that serum chemerin is an independent risk factor of prognosis of non-small cell lung cancer patients

3. CHN2 is consistently hypermethylated and downregulated in small bowel adenocarcinoma with diagnostic potential

4. CHN2, ABCB1 and PPP1R9A expression on chromosome 7 is implicated in the pathogenesis of hepatosplenic T-cell lymphoma distinguishing it from other malignancies.

5. genetic association studies in a population in Taiwan: Data suggest that an SNP in CHN2 (rs1002630) is associated with non-proliferative diabetic retinopathy in patients with diabetes type 2 in the Han Chinese population studied.

6. A significant association of the novel rs186911567 polymorphism was found for the CHN2 gene with smoking.

7. genetic association studies in a Chinese population with type 2 diabetes: An SNP in CHN2 (rs39059) is associated with diabetic retinopathy in a Chinese population of type 2 diabetic patients.

8. the Rac-GAP beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated phosphorylation

9. beta 2 chimerin has a role in rac-GAP-dependent inhibition of breast cancer cell proliferation

10. Data demonstrate that beta2-chimaerin provides a novel, diacylglycerol-dependent mechanism for Rac regulation in T cells and suggest a functional role for this protein in Rac-mediated cytoskeletal remodeling.

11. Beta2-chimaerin regulates the proliferation and migration of vascular smooth muscle cells downstream of growth factor signaling pathway implicating human atherogenesis.

12. results suggest Tyr-21 phosphorylation of beta2-chimaerin as a novel, Src-family kinase-dependent mechanism that negatively regulates beta2-chimaerin Rac-GAP activity

13. the interaction of diacylglycerol kinase gamma with the Src homology 2 and C1 domains of beta2-chimaerin is induced synergistically by Phorbol ester and hydrogen peroxide

14. Identify chimaerins as candidates for the downmodulation of Rac1 in T-lymphocytes and, in addition, uncover a novel regulatory mechanism that mediates their activation in T-cells.

15. Tyr-153 is the Lck-dependent phosphorylation residue and its phosphorylation negatively regulates membrane stabilization of beta2-chimaerin, decreasing its GAP activity to Rac

16. results suggest that beta2-chimaerin is activated by EphA receptors and mediates the EphA receptor-dependent regulation of cell migration

17. Likely digenic cause of insulin resistance and growth deficiency resulting from the combined heterozygous disruption of INSR and CHN2, implicating CHN2 for the first time as a key element of proximal insulin signaling in vivo.