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CHN2 Products

(Chimerin (Chimaerin) 2 (CHN2))

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This gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain and an SH2 domain. This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. The protein plays a role in the proliferation and migration of smooth muscle cells. Decreased expression of this gene is associated with high-grade gliomas and breast tumors, and increased expression of this gene is associated with lymphomas. Mutations in this gene have been associated with schizophrenia in men. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].

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Featured CHN2 Categories

CHN2 Antibodies

High quality antibodies with extensive validation data.

CHN2 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended CHN2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Application WB, IHC, IP, ICC
Validations
  • (3)
Cat. No. ABIN7444778
Quantity 100 μL
Datasheet Datasheet
Reactivity Rat
Application WB, IHC, ICC
Validations
  • (3)
Cat. No. ABIN5013327
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (1)
Cat. No. ABIN7145458
Quantity 100 μg
Datasheet Datasheet

Recommended CHN2 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6215198
Quantity 96 tests
Datasheet Datasheet

Recommended CHN2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3124411
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3091539
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7418860
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our CHN2 products

Alvi, McArt, Kelly, Fuchs, Alderdice, McCabe, Bingham, McGready, Tripathi, Emmert-Streib, Loughrey, McQuaid, Maxwell, Hamilton, Turkington, James, Wilson, Salto-Tellez: "Comprehensive molecular pathology analysis of small bowel adenocarcinoma reveals novel targets with potential for clinical utility." in: Oncotarget, Vol. 6, Issue 25, pp. 20863-74, (2015) (PubMed).

Siliceo, Mérida: "T cell receptor-dependent tyrosine phosphorylation of beta2-chimaerin modulates its Rac-GAP function in T cells." in: The Journal of biological chemistry, Vol. 284, Issue 17, pp. 11354-63, (2009) (PubMed).

Synonyms and alternative names related to CHN2

chimerin 2 (chn2), chimerin 2 (CHN2), chimerin 2 (Chn2), chimerin 2 L homeolog (chn2.L), 1700026N20Rik, 4930557O16Rik, ARHGAP3, Bch, BCH, CHN2-3, RHOGAP3

Protein level used designations for CHN2

  • beta chimerin
  • chimerin (chimaerin) 2
  • beta-chimaerin-like
  • beta-chimaerin
  • Rho GTPase-activating protein 3
  • beta chimaerin
  • beta-chimerin
  • beta3-chimaerin
  • chimaerin 2
  • rho-GTPase-activating protein 3
  • rho GTPase-activating protein 3
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