anti-Chloride Channel 2 (CLCN2) Antibodies

CLCN2 encodes a voltage-gated chloride channel. Additionally we are shipping Chloride Channel 2 Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CLCN2 12724 Q9R0A1
CLCN2 1181 P51788
CLCN2 29232 P35525
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Top anti-Chloride Channel 2 Antibodies at antibodies-online.com

Showing 10 out of 67 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated WB Western blot analysis of CLCN2 over-expressed 293 cell line, cotransfected with CLCN2 Validated Chimera RNAi used as specificity and loading control. Western Blot analysis of CLCN2 expression in transfected 293T cell line by CLCN2 monoclonal antibody (M01), clone 3E1. Lane 1: CLCN2 transfected lysate(96.8 KDa). Lane 2: Non-transfected lysate. 100 μg Log in to see 8 to 11 Days
$461.00
Details
Human Rabbit Un-conjugated EIA, WB <span>CLCN2 Antibody (N-term) western blot analysis in HL-60 cell line lysates (35µg/lane).This demonstrates the CLCN2 antibody detected the CLCN2 protein (arrow).</span> <span>CLCN2 Antibody (N-term) western blot analysis in mouse Neuro-2a cell line lysates (35µg/lane).This demonstrates the CLCN2 antibody detected the CLCN2 protein (arrow).</span> 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$481.25
Details
Human Goat Un-conjugated ELISA, WB Western Blot: CLCN2 Antibody [NBP1-52032] - Analysis of CLCN2 in HeLa lysate (35ug protein in RIPA buffer) using this antibody at 0.3 ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 7 to 9 Days
$485.88
Details
Human Goat Un-conjugated IHC, IHC (p) Human Uterus: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-CLCN2 antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Mouse Un-conjugated RNAi, ELISA, WB CLCN2 monoclonal antibody (M01), clone 3E1 Western Blot analysis of CLCN2 expression in Hela S3 NE . Western blot analysis of CLCN2 over-expressed 293 cell line, cotransfected with CLCN2 Validated Chimera RNAi (Lane 2) or non-transfected control (Lane 1). Blot probed with CLCN2 monoclonal antibody (M01), clone 3E1. GAPDH ( 36.1 kDa ) used as specificity and loading control. 100 μg Log in to see 11 to 12 Days
$440.00
Details
Bat Goat Un-conjugated ELISA, WB 100 μg Log in to see 7 to 9 Days
$610.50
Details
Human Rabbit Un-conjugated WB CLCN2 Antibody (N-term) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the CLCN2 antibody detected the CLCN2 protein (arrow). CLCN2 Antibody (N-term) western blot analysis in mouse Neuro-2a cell line lysates (35ug/lane).This demonstrates the CLCN2 antibody detected the CLCN2 protein (arrow). 400 μL Log in to see 10 to 11 Days
$335.50
Details
Cow Goat Un-conjugated EIA, WB   0.1 mg Log in to see 8 to 11 Days
$462.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunohistochemistry-Paraffin: CLCN2 Antibody [NBP1-33701] - Paraffin-embedded PC3 xenograft, using antibody at 1:100 dilution. Western Blot: CLCN2 Antibody [NBP1-33701] - Sample (30 ug of whole cell lysate) A: Molt-4 10% SDS PAGE; antibody diluted at 1:1000. 100 μL Log in to see 7 to 9 Days
$514.63
Details

CLCN2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Chloride Channel 2 Antibodies

  1. Human Monoclonal CLCN2 Primary Antibody for RNAi, ELISA - ABIN560397 : Alessi, Andjelkovic, Caudwell, Cron, Morrice, Cohen, Hemmings: Mechanism of activation of protein kinase B by insulin and IGF-1. in The EMBO journal 1997 (PubMed)
    Show all 4 Pubmed References

  2. Human Monoclonal CLCN2 Primary Antibody for WB - ABIN394461 : Ferrer, Corneo, Davis, Wan, Miyagishima, King, Maminishkis, Marugan, Sharma, Shure, Temple, Miller, Bharti: A multiplex high-throughput gene expression assay to simultaneously detect disease and functional markers in induced pluripotent stem cell-derived retinal pigment epithelium. in Stem cells translational medicine 2014 (PubMed)

  3. Human Polyclonal CLCN2 Primary Antibody for ELISA, WB - ABIN4299049 : Cornejo, Niemeyer, Zúñiga, Yusef, Sepúlveda, Cid: Rapid recycling of ClC-2 chloride channels between plasma membrane and endosomes: role of a tyrosine endocytosis motif in surface retrieval. in Journal of cellular physiology 2009 (PubMed)

More Antibodies against Chloride Channel 2 Interaction Partners

Zebrafish Chloride Channel 2 (CLCN2) interaction partners

  1. Identification and characterization of the zebrafish ClC (show CLCF1 Antibodies)-2a/b/c chloride channel (show CLCA1 Antibodies) orthologs.

Mouse (Murine) Chloride Channel 2 (CLCN2) interaction partners

  1. High fat diet -treated mice lacking ClC-2 showed inhibited hepatic lipid accumulation via regulating lipid metabolism through decreasing sterol regulatory element binding p (show ALT Antibodies)rotein (SREBP)-1c expression a (show TMPRSS11D Antibodies)nd its downst (show INS Antibodies)ream targeting enzymes such as fatty acid synthase (FAS), HMG-CoA reductase (HMGCR) and acetyl-Coenzyme A carboxylase (ACCalpha).

  2. Genetic ablation of ClC-2 resulted in reduced gastric gland region, reduced parietal cell number, reduced H/K ATPase (show ATP4b Antibodies), reduced tubulovesicles and reduced stimulated acid secretion.

  3. Data indicate that membrane protein MLC1 is crucial for proper localization of adhesion molecule (show NCAM1 Antibodies) GlialCAM (show HEPACAM Antibodies) and chloride channel (show CLCA1 Antibodies) ClC-2, and for changing ClC-2 currents.

  4. Loss of ClC-2 is associated with increased development of DSS (show PMP22 Antibodies)-induced colitis.

  5. The PCR data revealed the existence of two astrocytic subpopulations markedly differing in their gene expression levels for inwardly rectifying K+ channels (Kir4.1 (show KCNJ10 Antibodies)), K(2P) channels (TREK-1 (show KCNK2 Antibodies) and TWIK-1 (show KCNK1 Antibodies)) and Cl- channels (ClC2).

  6. ClC-2 channels are required for colonic electroneutral absorption of NaCl and KCl.

  7. permeant Cl(-) ions contribute to V(m)-dependent gating of the broadly distributed ClC-2 Cl() channel.

  8. GABAA (show GABRg1 Antibodies) receptor-mediated synaptic inputs from basket cells were modulated by ClC-2. Our data reveal a previously unknown cell type-specific regulation of intracellular chloride homeostasis in the perisomatic region of hippocampal pyramidal neurons.

  9. ClC-2 reduces barrier function in normal mucosa. Ultrastructural morphology of tight junctions and myosin light chain kinase (show MYLK Antibodies) appear to be important to the function of ClC-2 in normal mucosa.

  10. these findings raise the possibility that ClC-2 expression plays a subtle neuroprotective role in the aging hippocampus

Pig (Porcine) Chloride Channel 2 (CLCN2) interaction partners

  1. ClC-2-mediated intestinal Cl - secretion restores transepithelial resistance in ischemia-injured intestine.

Human Chloride Channel 2 (CLCN2) interaction partners

  1. Leukoencephalopathy-causing CLCN2 mutations impair chloride channel (show CLCA1 Antibodies) gating and trafficking.

  2. ClC-2 mRNA level was significantly increased in patients with non-alcoholic steatohepatitis, which positively correlated with the plasma levels of alanine transaminase (ALT), aspartate transaminase (AST) and insulin (show INS Antibodies).

  3. The findings show that RGET691 of human ClC-2 (possible binding site) plays an important functional role in fatty acid activation of human ClC-2.

  4. Hyperpolarization activates CLC-2 mainly by driving intracellular anions into the channel pores.

  5. The extracellular domain of GlialCAM (show HEPACAM Antibodies) is necessary for cell junction targeting and for mediating interactions with itself or with MLC1 and ClC-2.

  6. both ubiquitous (AP-1A) and epithelium-specific (AP-1B) forms of the tetrameric clathrin adaptor AP-1 (show FOSB Antibodies) are capable of carrying out basolateral sorting of ClC-2.

  7. SPAK (show STK39 Antibodies) and OSR1 (show OXSR1 Antibodies) are powerful negative regulators of the cell volume regulatory Cl- channel ClC-2

  8. Correlation between CLC-2 gene expression and the cytoskeleton in human trabecular meshwork cells.

  9. Our observations substantiate the concept that ClC-2 is involved in brain ion and water homoeostasis

  10. JAK2 (show JAK2 Antibodies) down-regulates ClC-2 activity and thus counteracts Cl(-) exit, an effect which may impact on cell volume regulation

Chloride Channel 2 (CLCN2) Antigen Profile

Protein Summary

This gene encodes a voltage-gated chloride channel. The encoded protein is a transmembrane protein that maintains chloride ion homeostasis in various cells. Defects in this gene may be a cause of certain epilepsies. Four transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with CLCN2

  • chloride voltage-gated channel 2 (CLCN2) antibody
  • chloride channel, voltage-sensitive 2a (clcn2a) antibody
  • chloride channel protein 2 (EHI_142170) antibody
  • chloride channel protein 2 (EHI_186860) antibody
  • chloride channel, voltage-sensitive 2 (Clcn2) antibody
  • chloride voltage-gated channel 2 (Clcn2) antibody
  • AL118368 antibody
  • CIC-2 antibody
  • clC-2 antibody
  • Clc2 antibody
  • CLCN2 antibody
  • ECA2 antibody
  • ECA3 antibody
  • EGI3 antibody
  • EGI11 antibody
  • EGMA antibody
  • EJM6 antibody
  • EJM8 antibody
  • LOC100150892 antibody
  • nmf240 antibody

Protein level used designations for CLCN2

chloride channel 2 , novel protein similar to vertebrate chloride channel 2 (CLCN2) , chloride channel protein 2 , PKA-activated chloride channel ClC-2G , clC-2

GENE ID SPECIES
704709 Macaca mulatta
100125625 Ovis aries
100150892 Danio rerio
3405494 Entamoeba histolytica HM-1:IMSS
3410767 Entamoeba histolytica HM-1:IMSS
12724 Mus musculus
505569 Bos taurus
100135500 Cavia porcellus
397147 Sus scrofa
1181 Homo sapiens
29232 Rattus norvegicus
488106 Canis lupus familiaris
100009530 Oryctolagus cuniculus
425295 Gallus gallus
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