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CLCN2 encodes a voltage-gated chloride channel. Additionally we are shipping Chloride Channel 2 Proteins (6) and many more products for this protein.
Showing 10 out of 68 products:
Human Monoclonal CLCN2 Primary Antibody for RNAi, ELISA - ABIN560397
Alessi, Andjelkovic, Caudwell, Cron, Morrice, Cohen, Hemmings: Mechanism of activation of protein kinase B by insulin and IGF-1. in The EMBO journal 1997
Show all 4 Pubmed References
Human Monoclonal CLCN2 Primary Antibody for WB - ABIN394461
Ferrer, Corneo, Davis, Wan, Miyagishima, King, Maminishkis, Marugan, Sharma, Shure, Temple, Miller, Bharti: A multiplex high-throughput gene expression assay to simultaneously detect disease and functional markers in induced pluripotent stem cell-derived retinal pigment epithelium. in Stem cells translational medicine 2014
Human Polyclonal CLCN2 Primary Antibody for ELISA, WB - ABIN4299049
Cornejo, Niemeyer, Zúñiga, Yusef, Sepúlveda, Cid: Rapid recycling of ClC-2 chloride channels between plasma membrane and endosomes: role of a tyrosine endocytosis motif in surface retrieval. in Journal of cellular physiology 2009
Identification and characterization of the zebrafish ClC (show CLCF1 Antibodies)-2a/b/c chloride channel (show CLCA1 Antibodies) orthologs.
High fat diet -treated mice lacking ClC-2 showed inhibited hepatic lipid accumulation via regulating lipid metabolism through decreasing sterol regulatory element binding p (show ALT Antibodies)rotein (SREBP)-1c expression a (show TMPRSS11D Antibodies)nd its downst (show INS Antibodies)ream targeting enzymes such as fatty acid synthase (FAS), HMG-CoA reductase (HMGCR) and acetyl-Coenzyme A carboxylase (ACCalpha).
Genetic ablation of ClC-2 resulted in reduced gastric gland region, reduced parietal cell number, reduced H/K ATPase (show ATP4b Antibodies), reduced tubulovesicles and reduced stimulated acid secretion.
Data indicate that membrane protein MLC1 is crucial for proper localization of adhesion molecule (show NCAM1 Antibodies) GlialCAM (show HEPACAM Antibodies) and chloride channel (show CLCA1 Antibodies) ClC-2, and for changing ClC-2 currents.
Loss of ClC-2 is associated with increased development of DSS (show PMP22 Antibodies)-induced colitis.
The PCR data revealed the existence of two astrocytic subpopulations markedly differing in their gene expression levels for inwardly rectifying K+ channels (Kir4.1 (show KCNJ10 Antibodies)), K(2P) channels (TREK-1 (show KCNK2 Antibodies) and TWIK-1 (show KCNK1 Antibodies)) and Cl- channels (ClC2).
ClC-2 channels are required for colonic electroneutral absorption of NaCl and KCl.
permeant Cl(-) ions contribute to V(m)-dependent gating of the broadly distributed ClC-2 Cl() channel.
GABAA (show GABRg1 Antibodies) receptor-mediated synaptic inputs from basket cells were modulated by ClC-2. Our data reveal a previously unknown cell type-specific regulation of intracellular chloride homeostasis in the perisomatic region of hippocampal pyramidal neurons.
ClC-2 reduces barrier function in normal mucosa. Ultrastructural morphology of tight junctions and myosin light chain kinase (show MYLK Antibodies) appear to be important to the function of ClC-2 in normal mucosa.
these findings raise the possibility that ClC-2 expression plays a subtle neuroprotective role in the aging hippocampus
ClC-2-mediated intestinal Cl - secretion restores transepithelial resistance in ischemia-injured intestine.
The inhibitory effects of ClC-2 knockout on HBVSMC proliferation and motility were associated with inactivation of the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling pathway, as evidenced by inhibition of beta-catenin (show CTNNB1 Antibodies) phosphorylation and nuclear translocation, and decrease of GSK-3beta phosphorylation and survivin and cyclin D1 (show CCND1 Antibodies) expression.
Leukoencephalopathy-causing CLCN2 mutations impair chloride channel (show CLCA1 Antibodies) gating and trafficking.
ClC-2 mRNA level was significantly increased in patients with non-alcoholic steatohepatitis, which positively correlated with the plasma levels of alanine transaminase (ALT), aspartate transaminase (AST) and insulin (show INS Antibodies).
The findings show that RGET691 of human ClC-2 (possible binding site) plays an important functional role in fatty acid activation of human ClC-2.
Hyperpolarization activates CLC-2 mainly by driving intracellular anions into the channel pores.
The extracellular domain of GlialCAM (show HEPACAM Antibodies) is necessary for cell junction targeting and for mediating interactions with itself or with MLC1 and ClC-2.
both ubiquitous (AP-1A) and epithelium-specific (AP-1B) forms of the tetrameric clathrin adaptor AP-1 (show FOSB Antibodies) are capable of carrying out basolateral sorting of ClC-2.
SPAK (show STK39 Antibodies) and OSR1 (show OXSR1 Antibodies) are powerful negative regulators of the cell volume regulatory Cl- channel ClC-2
Correlation between CLC-2 gene expression and the cytoskeleton in human trabecular meshwork cells.
Our observations substantiate the concept that ClC-2 is involved in brain ion and water homoeostasis
This gene encodes a voltage-gated chloride channel. The encoded protein is a transmembrane protein that maintains chloride ion homeostasis in various cells. Defects in this gene may be a cause of certain epilepsies. Four transcript variants encoding different isoforms have been found for this gene.
chloride channel 2
, novel protein similar to vertebrate chloride channel 2 (CLCN2)
, chloride channel protein 2
, PKA-activated chloride channel ClC-2G