anti-Chloride Channel 2 (CLCN2) Antibodies

CLCN2 encodes a voltage-gated chloride channel. Additionally we are shipping Chloride Channel 2 Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CLCN2 12724 Q9R0A1
CLCN2 1181 P51788
CLCN2 29232 P35525
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Top anti-Chloride Channel 2 Antibodies at

Showing 10 out of 72 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Goat Un-conjugated ELISA, WB   100 μg 6 to 7 Days
Human Rabbit Un-conjugated EIA, WB CLCN2 Antibody (N-term) western blot analysis in HL-60 cell line lysates (35µg/lane).This demonstrates the CLCN2 antibody detected the CLCN2 protein (arrow). CLCN2 Antibody (N-term) western blot analysis in mouse Neuro-2a cell line lysates (35µg/lane).This demonstrates the CLCN2 antibody detected the CLCN2 protein (arrow). 0.4 mL 6 to 8 Days
Human Goat Un-conjugated IHC, IHC (p) Human Uterus: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-CLCN2 antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml. 50 μg 11 to 14 Days
Human Mouse Un-conjugated RNAi, ELISA, WB CLCN2 monoclonal antibody (M01), clone 3E1 Western Blot analysis of CLCN2 expression in Hela S3 NE . Western blot analysis of CLCN2 over-expressed 293 cell line, cotransfected with CLCN2 Validated Chimera RNAi (Lane 2) or non-transfected control (Lane 1). Blot probed with CLCN2 monoclonal antibody (M01), clone 3E1. GAPDH ( 36.1 kDa ) used as specificity and loading control. 100 μg 11 to 12 Days
Bat Goat Un-conjugated ELISA, WB 100 μg 11 to 14 Days
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of CLCN2 using K562 whole cell lysates 100 μL 11 to 12 Days
Cow Goat Un-conjugated EIA, WB   0.1 mg 4 to 8 Days
Human Rabbit Un-conjugated WB Western blot analysis in HL-60 cell line lysates (35ug/lane). Western blot analysis in mouse Neuro-2a cell line lysates (35ug/lane). 400 μL 2 to 3 Days
Human Goat Un-conjugated IHC (p) Human Uterus: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg 6 to 8 Days
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of various cell lines, using CLCN2 Antibody (ABIN1877106) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s. 100 μL 11 to 13 Days

Top referenced anti-Chloride Channel 2 Antibodies

  1. Human Monoclonal CLCN2 Primary Antibody for RNAi, ELISA - ABIN560397 : Alessi, Andjelkovic, Caudwell, Cron, Morrice, Cohen, Hemmings: Mechanism of activation of protein kinase B by insulin and IGF-1. in The EMBO journal 1997 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal CLCN2 Primary Antibody for ELISA, WB - ABIN4299049 : Cornejo, Niemeyer, Zúñiga, Yusef, Sepúlveda, Cid: Rapid recycling of ClC-2 chloride channels between plasma membrane and endosomes: role of a tyrosine endocytosis motif in surface retrieval. in Journal of cellular physiology 2009 (PubMed)

More Antibodies against Chloride Channel 2 Interaction Partners

Zebrafish Chloride Channel 2 (CLCN2) interaction partners

  1. Identification and characterization of the zebrafish ClC-2a/b/c chloride channel orthologs.

Mouse (Murine) Chloride Channel 2 (CLCN2) interaction partners

  1. ClC-2 knockout results in less differentiated colonic crypts and increased tumorigenicity associated with colitis via dysregulation of AJ proteins.

  2. High fat diet -treated mice lacking ClC-2 showed inhibited hepatic lipid accumulation via regulating lipid metabolism through decreasing sterol regulatory element binding protein (SREBP)-1c expression and its downstream targeting enzymes such as fatty acid synthase (FAS), HMG-CoA reductase (HMGCR) and acetyl-Coenzyme A carboxylase (ACCalpha).

  3. Genetic ablation of ClC-2 resulted in reduced gastric gland region, reduced parietal cell number, reduced H/K ATPase, reduced tubulovesicles and reduced stimulated acid secretion.

  4. Data indicate that membrane protein MLC1 is crucial for proper localization of adhesion molecule GlialCAM and chloride channel ClC-2, and for changing ClC-2 currents.

  5. Loss of ClC-2 is associated with increased development of DSS-induced colitis.

  6. fast gate protonation was V(m) and Cl(-) independent and the equilibrium constant for closed-open transition of unprotonated channels was facilitated by elevated [Cl(-)](i) in a V(m)-dependent manner

  7. The PCR data revealed the existence of two astrocytic subpopulations markedly differing in their gene expression levels for inwardly rectifying K+ channels (Kir4.1), K(2P) channels (TREK-1 and TWIK-1) and Cl- channels (ClC2).

  8. ClC-2 channels are required for colonic electroneutral absorption of NaCl and KCl.

  9. permeant Cl(-) ions contribute to V(m)-dependent gating of the broadly distributed ClC-2 Cl() channel.

  10. GABAA receptor-mediated synaptic inputs from basket cells were modulated by ClC-2. Our data reveal a previously unknown cell type-specific regulation of intracellular chloride homeostasis in the perisomatic region of hippocampal pyramidal neurons.

  11. ClC-2 reduces barrier function in normal mucosa. Ultrastructural morphology of tight junctions and myosin light chain kinase appear to be important to the function of ClC-2 in normal mucosa.

  12. these findings raise the possibility that ClC-2 expression plays a subtle neuroprotective role in the aging hippocampus

  13. Heterozygous nmf240 mice present with a reduced electroretinography light peak component suggests that CLCN2 is necessary for the generation of this response component.

  14. we suggest a dual role for ClC-2 in neurons, providing an additional efflux pathway for chloride and constituting a substantial part of the background conductance, which regulates excitability.

  15. ClC-2 is unlikely to be a candidate rescue channel in cystic fibrosis

  16. activation of host ClC-2 channels participates in the altered permeability of Plasmodium-infected erythrocytes but is not required for intraerythrocytic parasite survival

  17. This study concluded that Clcn2is the inward-rectifying chloride channel in duct cells, but its expression is not apparently required for the ion reabsorption or the barrier function of salivary ductal epithelium.

  18. These data demonstrate a pivotal role of ClC-2 in recovery of the intestinal epithelium barrier by anchoring assembly of tight junctions following ischemic injury.

Pig (Porcine) Chloride Channel 2 (CLCN2) interaction partners

  1. ClC-2-mediated intestinal Cl - secretion restores transepithelial resistance in ischemia-injured intestine.

Human Chloride Channel 2 (CLCN2) interaction partners

  1. A role of anion channels in glomerulosa membrane potential determination, aldosterone production and hypertension. The mutations are the cause of a substantial fraction of early-onset primary aldosteronism.

  2. CLCN2 mutations cause primary aldosteronism, this highlight the importance of chloride in aldosterone biosynthesis and CLCN2 as the foremost chloride conductor of resting glomerulosa cells.

  3. The inhibitory effects of ClC-2 knockout on HBVSMC proliferation and motility were associated with inactivation of the Wnt/beta-catenin signaling pathway, as evidenced by inhibition of beta-catenin phosphorylation and nuclear translocation, and decrease of GSK-3beta phosphorylation and survivin and cyclin D1 expression.

  4. Leukoencephalopathy-causing CLCN2 mutations impair chloride channel gating and trafficking.

  5. ClC-2 mRNA level was significantly increased in patients with non-alcoholic steatohepatitis, which positively correlated with the plasma levels of alanine transaminase (ALT), aspartate transaminase (AST) and insulin.

  6. The findings show that RGET691 of human ClC-2 (possible binding site) plays an important functional role in fatty acid activation of human ClC-2.

  7. Hyperpolarization activates CLC-2 mainly by driving intracellular anions into the channel pores.

  8. The extracellular domain of GlialCAM is necessary for cell junction targeting and for mediating interactions with itself or with MLC1 and ClC-2.

  9. both ubiquitous (AP-1A) and epithelium-specific (AP-1B) forms of the tetrameric clathrin adaptor AP-1 are capable of carrying out basolateral sorting of ClC-2.

  10. SPAK and OSR1 are powerful negative regulators of the cell volume regulatory Cl- channel ClC-2

  11. Correlation between CLC-2 gene expression and the cytoskeleton in human trabecular meshwork cells.

  12. Our observations substantiate the concept that ClC-2 is involved in brain ion and water homoeostasis

  13. JAK2 down-regulates ClC-2 activity and thus counteracts Cl(-) exit, an effect which may impact on cell volume regulation

  14. This study demonistrated that the first auxiliary subunit of ClC-2 and suggests that ClC-2 may play a role in the pathology of MLC disease.

  15. ClC-2 plays an important role in the modulation of tight junctions by influencing caveolar trafficking of tight junction protein occludin.

  16. Sequence analysis of CLCN2 at genomic DNA and cDNA levels in 18 megalencephalic leukoencephalopathy MLC1 mutations revealed some nucleotide changes, but they were predicted to be nonpathogenic.

  17. found significant expression of ClC-2 at the apex of ciliated cells in both rat and human airways

  18. a functional interaction between the ClC-2 chloride channel and the retrograde motor dynein complex.

  19. ClC-2 and ClC-3 channels are specifically upregulated in glioma membranes and endow glioma cells with an enhanced ability to transport Chloride

  20. activation of hClC-2 is differentially regulated by PKA at two sites

Chloride Channel 2 (CLCN2) Antigen Profile

Protein Summary

This gene encodes a voltage-gated chloride channel. The encoded protein is a transmembrane protein that maintains chloride ion homeostasis in various cells. Defects in this gene may be a cause of certain epilepsies. Four transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with CLCN2

  • chloride voltage-gated channel 2 (CLCN2) antibody
  • chloride channel, voltage-sensitive 2a (clcn2a) antibody
  • chloride channel protein 2 (EHI_142170) antibody
  • chloride channel protein 2 (EHI_186860) antibody
  • chloride channel, voltage-sensitive 2 (Clcn2) antibody
  • chloride voltage-gated channel 2 (Clcn2) antibody
  • AL118368 antibody
  • CIC-2 antibody
  • clC-2 antibody
  • Clc2 antibody
  • CLCN2 antibody
  • ECA2 antibody
  • ECA3 antibody
  • EGI3 antibody
  • EGI11 antibody
  • EGMA antibody
  • EJM6 antibody
  • EJM8 antibody
  • LOC100150892 antibody
  • nmf240 antibody

Protein level used designations for CLCN2

chloride channel 2 , novel protein similar to vertebrate chloride channel 2 (CLCN2) , chloride channel protein 2 , PKA-activated chloride channel ClC-2G , clC-2

704709 Macaca mulatta
100125625 Ovis aries
100150892 Danio rerio
3405494 Entamoeba histolytica HM-1:IMSS
3410767 Entamoeba histolytica HM-1:IMSS
12724 Mus musculus
505569 Bos taurus
100135500 Cavia porcellus
397147 Sus scrofa
1181 Homo sapiens
29232 Rattus norvegicus
488106 Canis lupus familiaris
100009530 Oryctolagus cuniculus
425295 Gallus gallus
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