anti-Chloride Channel 3 (CLCN3) Antibodies

CLCN3 encodes a calcium-independent phospholipid-binding protein whose expression increases in serum-starved cells.

list all antibodies Gene Name GeneID UniProt
Anti-Human CLCN3 CLCN3 1182 P51790
Anti-Rat CLCN3 CLCN3 84360 P51792
Anti-Mouse CLCN3 CLCN3 12725 P51791
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Top anti-Chloride Channel 3 Antibodies at antibodies-online.com

Showing 10 out of 128 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-CLCN3 Antibody Titration:  1.25ug/ml  ELISA Titer:  1:1562500  Positive Control:  HepG2 cell lysate Human Brain 100 μL Log in to see 2 to 3 Days
$229.00
Details
Bat Rabbit Un-conjugated IHC, IHC (p), WB 100 μg Log in to see 7 to 9 Days
$493.17
Details
Human Rabbit Un-conjugated WB CLCN3 Antibody (Center)  western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the CLCN3 antibody detected the CLCN3 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse HRP ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Clcn3 Monoclonal Antibody, Clone S258-5 . Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-Clcn3 Monoclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Membrane, Endosome, Endosome membrane, Cytoplasmic Vesicle, Secretory Vesicle Membrane. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) Clcn3 Antibody (D) Composite. Western Blot analysis of Rat Brain Membrane showing detection of ~90 kDa CIcn3 protein using Mouse Anti-CIcn3 Monoclonal Antibody, Clone S258-5 . Lane 1: Molecular Weight Ladder. Lane 2: Rat Brain Membrane. Load: 15 µg. Block: 2% BSA and 2% Skim Milk in 1X TBST. Primary Antibody: Mouse Anti-CIcn3 Monoclonal Antibody  at 1:200 for 16 hours at 4°C. Secondary Antibody: Goat Anti-Mouse IgG: HRP at 1:1000 for 1 hour RT. Color Development: ECL solution for 6 min in RT. Predicted/Observed Size: ~90 kDa. 100 μg Log in to see 2 to 3 Days
$422.40
Details
Human Mouse FITC ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Clcn3 Monoclonal Antibody, Clone S258-5 . Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-Clcn3 Monoclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Membrane, Endosome, Endosome membrane, Cytoplasmic Vesicle, Secretory Vesicle Membrane. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) Clcn3 Antibody (D) Composite. Western Blot analysis of Rat Brain Membrane showing detection of ~90 kDa CIcn3 protein using Mouse Anti-CIcn3 Monoclonal Antibody, Clone S258-5 . Lane 1: Molecular Weight Ladder. Lane 2: Rat Brain Membrane. Load: 15 µg. Block: 2% BSA and 2% Skim Milk in 1X TBST. Primary Antibody: Mouse Anti-CIcn3 Monoclonal Antibody  at 1:200 for 16 hours at 4°C. Secondary Antibody: Goat Anti-Mouse IgG: HRP at 1:1000 for 1 hour RT. Color Development: ECL solution for 6 min in RT. Predicted/Observed Size: ~90 kDa. 100 μg Log in to see 2 to 3 Days
$426.80
Details
Human Mouse Alkaline Phosphatase (AP) ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Clcn3 Monoclonal Antibody, Clone S258-5 . Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-Clcn3 Monoclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Membrane, Endosome, Endosome membrane, Cytoplasmic Vesicle, Secretory Vesicle Membrane. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) Clcn3 Antibody (D) Composite. Western Blot analysis of Rat Brain Membrane showing detection of ~90 kDa CIcn3 protein using Mouse Anti-CIcn3 Monoclonal Antibody, Clone S258-5 . Lane 1: Molecular Weight Ladder. Lane 2: Rat Brain Membrane. Load: 15 µg. Block: 2% BSA and 2% Skim Milk in 1X TBST. Primary Antibody: Mouse Anti-CIcn3 Monoclonal Antibody  at 1:200 for 16 hours at 4°C. Secondary Antibody: Goat Anti-Mouse IgG: HRP at 1:1000 for 1 hour RT. Color Development: ECL solution for 6 min in RT. Predicted/Observed Size: ~90 kDa. 100 μg Log in to see 2 to 3 Days
$429.00
Details
Human Mouse Biotin ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Clcn3 Monoclonal Antibody, Clone S258-5 . Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-Clcn3 Monoclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Membrane, Endosome, Endosome membrane, Cytoplasmic Vesicle, Secretory Vesicle Membrane. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) Clcn3 Antibody (D) Composite. Western Blot analysis of Rat Brain Membrane showing detection of ~90 kDa CIcn3 protein using Mouse Anti-CIcn3 Monoclonal Antibody, Clone S258-5 . Lane 1: Molecular Weight Ladder. Lane 2: Rat Brain Membrane. Load: 15 µg. Block: 2% BSA and 2% Skim Milk in 1X TBST. Primary Antibody: Mouse Anti-CIcn3 Monoclonal Antibody  at 1:200 for 16 hours at 4°C. Secondary Antibody: Goat Anti-Mouse IgG: HRP at 1:1000 for 1 hour RT. Color Development: ECL solution for 6 min in RT. Predicted/Observed Size: ~90 kDa. 100 μg Log in to see 2 to 3 Days
$431.20
Details
Human Mouse PE ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Clcn3 Monoclonal Antibody, Clone S258-5 . Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-Clcn3 Monoclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Membrane, Endosome, Endosome membrane, Cytoplasmic Vesicle, Secretory Vesicle Membrane. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) Clcn3 Antibody (D) Composite. Western Blot analysis of Rat Brain Membrane showing detection of ~90 kDa CIcn3 protein using Mouse Anti-CIcn3 Monoclonal Antibody, Clone S258-5 . Lane 1: Molecular Weight Ladder. Lane 2: Rat Brain Membrane. Load: 15 µg. Block: 2% BSA and 2% Skim Milk in 1X TBST. Primary Antibody: Mouse Anti-CIcn3 Monoclonal Antibody  at 1:200 for 16 hours at 4°C. Secondary Antibody: Goat Anti-Mouse IgG: HRP at 1:1000 for 1 hour RT. Color Development: ECL solution for 6 min in RT. Predicted/Observed Size: ~90 kDa. 100 μg Log in to see 2 to 3 Days
$432.30
Details
Human Mouse Streptavidin ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Clcn3 Monoclonal Antibody, Clone S258-5 . Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-Clcn3 Monoclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Membrane, Endosome, Endosome membrane, Cytoplasmic Vesicle, Secretory Vesicle Membrane. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) Clcn3 Antibody (D) Composite. Western Blot analysis of Rat Brain Membrane showing detection of ~90 kDa CIcn3 protein using Mouse Anti-CIcn3 Monoclonal Antibody, Clone S258-5 . Lane 1: Molecular Weight Ladder. Lane 2: Rat Brain Membrane. Load: 15 µg. Block: 2% BSA and 2% Skim Milk in 1X TBST. Primary Antibody: Mouse Anti-CIcn3 Monoclonal Antibody  at 1:200 for 16 hours at 4°C. Secondary Antibody: Goat Anti-Mouse IgG: HRP at 1:1000 for 1 hour RT. Color Development: ECL solution for 6 min in RT. Predicted/Observed Size: ~90 kDa. 100 μg Log in to see 2 to 3 Days
$433.40
Details
Human Mouse PerCP ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Clcn3 Monoclonal Antibody, Clone S258-5 . Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-Clcn3 Monoclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Membrane, Endosome, Endosome membrane, Cytoplasmic Vesicle, Secretory Vesicle Membrane. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) Clcn3 Antibody (D) Composite. Western Blot analysis of Rat Brain Membrane showing detection of ~90 kDa CIcn3 protein using Mouse Anti-CIcn3 Monoclonal Antibody, Clone S258-5 . Lane 1: Molecular Weight Ladder. Lane 2: Rat Brain Membrane. Load: 15 µg. Block: 2% BSA and 2% Skim Milk in 1X TBST. Primary Antibody: Mouse Anti-CIcn3 Monoclonal Antibody  at 1:200 for 16 hours at 4°C. Secondary Antibody: Goat Anti-Mouse IgG: HRP at 1:1000 for 1 hour RT. Color Development: ECL solution for 6 min in RT. Predicted/Observed Size: ~90 kDa. 100 μg Log in to see 2 to 3 Days
$434.50
Details

Top referenced anti-Chloride Channel 3 Antibodies

  1. Mammalian Monoclonal CLCN3 Primary Antibody for WB - ABIN1304600 : Gaurav, Bewtra, Agrawal: Novel CLC3 transcript variants in blood eosinophils and increased CLC3 expression in nasal lavage and blood eosinophils of asthmatics. in Immunity, inflammation and disease 2015 (PubMed)
    Show all 3 Pubmed References

  2. Cow (Bovine) Polyclonal CLCN3 Primary Antibody for IHC, WB - ABIN2776327 : Salazar, Love, Styers, Werner, Peden, Rodriguez, Gearing, Wainer, Faundez: AP-3-dependent mechanisms control the targeting of a chloride channel (ClC-3) in neuronal and non-neuronal cells. in The Journal of biological chemistry 2004 (PubMed)
    Show all 2 Pubmed References

  3. Rat (Rattus) Polyclonal CLCN3 Primary Antibody for WB - ABIN1742509 : Eckenstaler, Lessmann, Brigadski: CAPS1 effects on intragranular pH and regulation of BDNF release from secretory granules in hippocampal neurons. in Journal of cell science 2016 (PubMed)

  4. Human Polyclonal CLCN3 Primary Antibody for IF (p), IHC (p) - ABIN1386131 : Larrouture, Nelson, Robinson, Liu, Tourkova, Schlesinger, Blair: Chloride-hydrogen antiporters ClC-3 and ClC-5 drive osteoblast mineralization and regulate fine-structure bone patterning in vitro. in Physiological reports 2015 (PubMed)

More Antibodies against Chloride Channel 3 Interaction Partners

Human Chloride Channel 3 (CLCN3) interaction partners

  1. CLC-3 may get involved in proliferation, invasion, and migration of ovarian cancer cells and thus may be a useful therapeutic target.

  2. Transfection of cells with ClC-3 siRNA decreased the expression of cyclin D1 (show CCND1 Antibodies), cyclin dependent kinase 4 (show CDK4 Antibodies) and 6, and increased the expression of cyclin dependent kinase (show CDK1 Antibodies) inhibitors (CDKIs), p21 (show CDKN1A Antibodies) and p27 (show PAK2 Antibodies). Pretreatments of cells with p21 (show CDKN1A Antibodies) and p27 (show PAK2 Antibodies) siRNAs depleted the inhibitory effects of ClC-3 siRNA on the expression of CDK4 (show CDK4 Antibodies) and CDK6 (show CDK6 Antibodies), but not on that of cyclin D1 (show CCND1 Antibodies)

  3. ClC-3 is a potential target of 17beta-estradiol and is modulated by the ERalpha (show ESR1 Antibodies) in breast cancer cells.

  4. Study provided novel and compelling evidence for the functional role of the unique CLC-3, which are significantly upregulated during ischemia, in the protection of the heart under stress

  5. ClC-3 promotes endometriotic cell migration and invasion.

  6. these results demonstrated that ClC-3 is involved in the proliferation and migration of osteosarcoma cell

  7. Data indicate that cytoplasmic chloride channel-3 (ClC-3) plays an active and key role in tumor metastasis and may be a valuable prognostic biomarker and a therapeutic target to prevent tumor spread.

  8. CLC3 is required in the activation and migration of human blood eosinophils.

  9. Authors summarize the function of CLC-3 in cancer and discuss the mechanisms by which CLC-3 contributes to proliferation, apoptosis and drug resistance in cancer cells. [Review]

  10. swelling-activated Cl currents and CLC-3 play a role in pulmonary artery smooth muscle cell proliferation, but CLC-3 channels do not underlie swelling in these cells

Mouse (Murine) Chloride Channel 3 (CLCN3) interaction partners

  1. Abrogating ClC-3 blunts lipopolysaccharide-induced Inflammation via blocking the TLR4 (show TLR4 Antibodies)/NF-kappaB (show NFKB1 Antibodies) pathway.

  2. Results have shown that the expression of ClC-3 was reduced in hypertrophic H9c2 cells, primary rat neonatal cardiomyocytes and myocardium of C57/BL/6 mice and that ClC-3 played an important role in beta-adrenergic cardiac hypertrophy.

  3. we conclude that the expression of ClC-3 chloride channels in osteoblasts helps them respond to PTH (show PTH Antibodies) stimulation, which mediates osteogenic differentiation.

  4. our findings show that Cl(-) channels can be activated by estrogen via ERa on the cell membrane and suggest that the ClC-3 Cl(-) channel may be one of the targets of estrogen in the regulation of osteoblast activity.

  5. ClC-3 is an endogenous inhibitor of neuropathic pain development and down-regulation of ClC-3 contributes to mechanical hypersensitivity.

  6. This study provides a new mechanism by which endophilin A2 (show SH3GL1 Antibodies) regulates ClC-3 channel activity, and sheds light on how ClC-3 is transported to cell membranes to play its critical role as a chloride channel (show CLCA1 Antibodies) in VSMCs function

  7. roles of AQP-3 (show AQP3 Antibodies) in AQP-3 (show AQP3 Antibodies) aquaglyceroporin and ClC-3 chloride channels complex

  8. ClC-3 plays a major role in hyperglycemia induced hippocampal neuronal apoptosis.

  9. Threonine532 phosphorylation in ClC-3 channels is required for angiotensin II-induced Cl(-) current and migration in cultured vascular smooth muscle cells

  10. Data suggest that ClC3/Clcn3 expression is up-regulated by mechanical stimulation (persistent static compression here) in osteoblastic cell line and appears to participate in mechanically sensitive osteogenesis and gene expression regulation.

Guinea Pig Chloride Channel 3 (CLCN3) interaction partners

  1. ClC-3 is specialized in mainly performing incomplete capacitive nontransporting cycles in intracellular membranes.

Xenopus laevis Chloride Channel 3 (CLCN3) interaction partners

  1. A local enhancement of CIC (show CIC Antibodies)-3 expression at the leading edge of the wounded epidermis was found to be specific to closing wounds.

Chloride Channel 3 (CLCN3) Antigen Profile

Protein Summary

This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with CLCN3

  • chloride voltage-gated channel 3 (CLCN3) antibody
  • chloride voltage-gated channel 3 (Clcn3) antibody
  • chloride channel, voltage-sensitive 3 (Clcn3) antibody
  • chloride channel 3 (clcn3) antibody
  • chloride channel protein 3 (PTRG_03131) antibody
  • chloride channel protein 3 (BDBG_05668) antibody
  • chloride channel protein 3 (MCYG_04420) antibody
  • chloride channel, voltage-sensitive 3 (clcn3) antibody
  • chloride channel, voltage-sensitive 3 S homeolog (clcn3.S) antibody
  • clc-3 antibody
  • clc3 antibody
  • CLCN3 antibody
  • fb78c02 antibody
  • wu:fb78c02 antibody

Protein level used designations for CLCN3

H(+)/Cl(-) exchange transporter 3 , chloride channel 3 , chloride channel protein 3 , chloride transporter ClC-3 , protein kinase C-regulated chloride channel , clC-3 , chloride channel Clc-3 , Chloride channel protein 3 , H(+)/Cl(-) exchange transporter 3-like , putative chloride channel ClC-3

GENE ID SPECIES
1182 Homo sapiens
84360 Rattus norvegicus
12725 Mus musculus
422432 Gallus gallus
471346 Pan troglodytes
477354 Canis lupus familiaris
522719 Bos taurus
559340 Danio rerio
6341356 Pyrenophora tritici-repentis Pt-1C-BFP
8503901 Ajellomyces dermatitidis SLH14081
9229794 Arthroderma otae CBS 113480
100008673 Oryctolagus cuniculus
100021050 Monodelphis domestica
100061225 Equus caballus
100074971 Ornithorhynchus anatinus
100135501 Cavia porcellus
100156049 Sus scrofa
100174300 Pongo abelii
100216107 Xenopus (Silurana) tropicalis
100380301 Salmo salar
100404608 Callithrix jacchus
100581879 Nomascus leucogenys
399089 Xenopus laevis
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