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CLCN3 Products

(Chloride Channel 3 (CLCN3))

Categories

This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011].

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Featured CLCN3 Categories

CLCN3 Antibodies

High quality antibodies with extensive validation data.

CLCN3 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended CLCN3 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet

Application IHC, WB
Validations
  • (1)
  • (5)
Cat. No. ABIN2776327
Quantity 100 μL
Datasheet Datasheet
Reactivity Rat
Application ICC, IF, IHC, WB
Validations
  • (3)
Cat. No. ABIN1027722
Quantity 100 μg
Datasheet Datasheet
Reactivity Rat
Application ICC, IF, IHC, WB
Validations
  • (3)
Cat. No. ABIN2485482
Quantity 100 μg
Datasheet Datasheet

Recommended CLCN3 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3077940
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3077941
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3134381
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our CLCN3 products

Eckenstaler, Lessmann, Brigadski: "CAPS1 effects on intragranular pH and regulation of BDNF release from secretory granules in hippocampal neurons." in: Journal of cell science, Vol. 129, Issue 7, pp. 1378-90, (2016) (PubMed).

Gaurav, Bewtra, Agrawal: "Novel CLC3 transcript variants in blood eosinophils and increased CLC3 expression in nasal lavage and blood eosinophils of asthmatics." in: Immunity, inflammation and disease, Vol. 2, Issue 4, pp. 205-13, (2015) (PubMed).

Larrouture, Nelson, Robinson, Liu, Tourkova, Schlesinger, Blair: "Chloride-hydrogen antiporters ClC-3 and ClC-5 drive osteoblast mineralization and regulate fine-structure bone patterning in vitro." in: Physiological reports, Vol. 3, Issue 11, (2015) (PubMed).

Cuddapah, Turner, Sontheimer: "Calcium entry via TRPC1 channels activates chloride currents in human glioma cells." in: Cell calcium, Vol. 53, Issue 3, pp. 187-94, (2013) (PubMed).

Jensen, Nosjean, Dziegiel, Boutin, Sørensen, Karsdal, Henriksen: "A quantitative assay for lysosomal acidification rates in human osteoclasts." in: Assay and drug development technologies, Vol. 9, Issue 2, pp. 157-64, (2011) (PubMed).

McMains, Krishnan, Prasad, Gleason: "Expression and localization of CLC chloride transport proteins in the avian retina." in: PLoS ONE, Vol. 6, Issue 3, pp. e17647, (2011) (PubMed).

Synonyms and alternative names related to CLCN3

chloride voltage-gated channel 3 (CLCN3), chloride voltage-gated channel 3 (Clcn3), chloride channel, voltage-sensitive 3 (Clcn3), chloride channel 3 (clcn3), chloride channel protein 3 (PTRG_03131), chloride channel protein 3 (BDBG_05668), chloride channel protein 3 (MCYG_04420), chloride channel, voltage-sensitive 3 (clcn3), chloride channel, voltage-sensitive 3 S homeolog (clcn3.S), ClC-3, clc-3, CLC3, Clc3, clc3, CLCN3, fb78c02, wu:fb78c02

Protein level used designations for CLCN3

  • H(+)/Cl(-) exchange transporter 3
  • chloride channel 3
  • chloride channel protein 3
  • chloride transporter ClC-3
  • protein kinase C-regulated chloride channel
  • clC-3
  • chloride channel Clc-3
  • Chloride channel protein 3
  • H(+)/Cl(-) exchange transporter 3-like
  • putative chloride channel ClC-3
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