Chloride Channel Accessory 1 Proteins (CLCA1)

CLCA1 encodes a member of the calcium sensitive chloride conductance protein family. Additionally we are shipping Chloride Channel Accessory 1 Antibodies (64) and Chloride Channel Accessory 1 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CLCA1 1179 A8K7I4
Rat CLCA1 CLCA1 308015  
CLCA1 23844 Q9D7Z6
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Top Chloride Channel Accessory 1 Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,984.89
Details
Insect Cells Mouse rho-1D4 tag,His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,984.89
Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 18 Days
$752.00
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Escherichia coli (E. coli) Human His tag Figure. SDS-PAGE; Sample: Active recombinant CLCA1, Human. 100 μg Log in to see 15 to 18 Days
$1,280.00
Details
Escherichia coli (E. coli) Human Un-conjugated SDS-PAGE analysis of Human CLCA1 Protein. 100 μg Log in to see 11 to 18 Days
$682.25
Details

CLCA1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Chloride Channel Accessory 1 (CLCA1) Interaction Partners

Human Chloride Channel Accessory 1 (CLCA1) interaction partners

  1. Results suggest that CLCA1 is involved in intestinal mucus homeostasis by facilitating processing and removal of mucus to prevent stagnation.

  2. CLCA1 suppresses colorectal cancer aggressiveness via inhibition of the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway

  3. Increase in TMEM16A (show ANO1 Proteins) activity occurred within minutes of exposure to CLCA1 or after a short treatment with nocodazole, consistent with the hypothesis that CLCA1 stabilizes TMEM16A (show ANO1 Proteins) at the cell surface by preventing its internalization.

  4. Data show that calcium-activated chloride channel regulator 1 (CLCA1) and transmembrane protein 16A (TMEM16A (show ANO1 Proteins)) co-localize and physically interact and that CLCA1 increases the level of TMEM16A (show ANO1 Proteins) protein at the cell surface.

  5. inhibitor and siRNA transfection studies demonstrated an apparent effect of CLCA1 on ovarian cancer cell aggregation

  6. Results confirmed that the low expression of CLCA1 in CRC (show CALR Proteins) was associated with tumorigenesis, early metastasis, and high chromosomal instability. Low expression of CLCA1 predicts recurrence and lower survival.

  7. These findings demonstrate the ability of hCLCA1 to function as a signaling molecule and activate macrophages, central regulators of airway inflammation.

  8. CLCA1 may contribute to promoting spontaneous differentiation and reducing proliferation of Caco-2 cells.

  9. CLCA1 expression is significantly related to mucus production in the airway epithelia of smokers and COPD (show ARCN1 Proteins) patients, and may contribute to the development and pathogenesis of COPD (show ARCN1 Proteins) by inducing mucus production.

  10. These data provide both a mechanistic basis for CLCA1 self-cleavage and a novel mechanism for regulation of chloride channel activity specific to the mucosal interface.

Horse (Equine) Chloride Channel Accessory 1 (CLCA1) interaction partners

  1. These data implicate CLCA1 in the expression of eqMUC5AC in horses; and suggest regulation by CLCA1 and epidermal growth factor receptor (show EGFR Proteins) between horses with recurrent airway obstruction and those with milder degrees of inflammation.

  2. In this study, eCLCA1 protein and mRNA expression were quantified in airway goblet cells of horses with RAO (show AOC2 Proteins) and controls using immunohistochemistry and laser microdissection followed by RT-PCR, respectively.

Pig (Porcine) Chloride Channel Accessory 1 (CLCA1) interaction partners

  1. pCLCA1 shares essential characteristics of hCLCA1, supporting the pig model as a promising tool for studying the modulating role of pCLCA1 in the complex pathology of cystic fibrosis (show S100A8 Proteins).

  2. pCLCA1 expression may increase the sensitivity of preexisting endogenous Cl(-) channels to Ca(2 (show CA2 Proteins)+) and cAMP agonists but apparently lacks inherent Cl(-) channel activity under growth conditions where endogenous channels are not expressed

Mouse (Murine) Chloride Channel Accessory 1 (CLCA1) interaction partners

  1. Results suggest that CLCA1 is involved in intestinal mucus homeostasis by facilitating processing and removal of mucus to prevent stagnation.

  2. The data underscore and specify the role of mouse CLCA1 in inflammatory airway disease to activate airway macrophages.

  3. Clca1 is not required for mucus synthesis, structure and barrier function in the murine colon.

  4. mCLCA3 appears to modulate leukocyte response via IL-17 (show IL17A Proteins) and murine CXCL-8 (show IL8 Proteins) homologs in acute Staphylococcus aureus pneumonia which is well in line with the proposed function of hCLCA1 as a signaling molecule acting on alveolar macrophages.

  5. Findings suggest that increased expression of a single-gene, mCLCA3, could simulate an asthma attack, and its mechanism may involve mCLCA3 overexpression up-regulating IL-13 (show IL13 Proteins) expression.

  6. PA-LPS (show TLR4 Proteins)-induced MUC5AC and Clca3 expression is partly through Duox1 (show DUOX1 Proteins)

  7. these findings argue against a role of mCLCA3 in Ca(2 (show CA2 Proteins) )-activated Cl(-) channel-mediated Cl(-) secretion in murine respiratory epithelia

  8. a functional link between two distinct anion currents, ClC-3 (show CLCN3 Proteins) and swelling-activated chloride current

  9. conclude that hCLCA1 and mCLCA3 are non-integral membrane proteins and therefore cannot be chloride channels in their own right

  10. Gob-5 expression is not essential for mucin (show SLC13A2 Proteins) overproduction in vitro or in murine models of allergic asthma

Chloride Channel Accessory 1 (CLCA1) Protein Profile

Protein Summary

This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine.

Gene names and symbols associated with CLCA1

  • chloride channel accessory 1 (CLCA1)
  • chloride channel accessory 1 (Clca1)
  • chloride channel accessory 1 (clca1)
  • chloride channel (clcA1)
  • chloride channel protein (clcA1)
  • AECC protein
  • CACC protein
  • CaCC-1 protein
  • CACC1 protein
  • Clca1 protein
  • Clca2 protein
  • Clca3 protein
  • CLCRG1 protein
  • fi39d11 protein
  • gob-5 protein
  • gob5 protein
  • hCaCC-1 protein
  • hCLCA1 protein
  • wu:fi39d11 protein

Protein level used designations for CLCA1

CLCA family member 1, chloride channel regulator , calcium-activated chloride channel family member 1 , calcium-activated chloride channel protein 1 , calcium-activated chloride channel regulator 1 , calcium-dependent chloride channel-1 , chloride channel regulator 1 , chloride channel, calcium activated, family member 1 , calcium activated chloride channel 1 , calcium activated chloride channel-like protein 1 , chloride channel family member 1 , eCLCA1 , chloride channel calcium activated 3 , chloride channel accessory 1 , epithelial chloride channel protein , Clca1 protein , chloride channel , chloride channel protein , calcium-activated chloride channel regulator 1-like , calcium-activated chloride channel family member 3 , chloride channel calcium activated 2 , mCLCA3 , protein gob-5

GENE ID SPECIES
1179 Homo sapiens
456640 Pan troglodytes
490178 Canis lupus familiaris
507643 Bos taurus
574295 Macaca mulatta
100009706 Equus caballus
308015 Rattus norvegicus
334289 Danio rerio
397284 Sus scrofa
594875 Xenopus (Silurana) tropicalis
6321729 Xanthomonas campestris pv. campestris str. B100
9398586 Leuconostoc gasicomitatum LMG 18811
100386069 Callithrix jacchus
100442837 Pongo abelii
100604179 Nomascus leucogenys
23844 Mus musculus
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