Chloride Channel Accessory 1 Proteins (CLCA1)

CLCA1 encodes a member of the calcium sensitive chloride conductance protein family. Additionally we are shipping Chloride Channel Accessory 1 Antibodies (61) and Chloride Channel Accessory 1 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CLCA1 1179 A8K7I4
Rat CLCA1 CLCA1 308015  
CLCA1 23844 Q9D7Z6
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Top Chloride Channel Accessory 1 Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
$13,741.67
Details
Insect Cells Mouse rho-1D4 tag,His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
$13,741.67
Details
Escherichia coli (E. coli) Human His tag 100 μg 15 to 18 Days
$752.00
Details
Wheat germ Human GST tag 10 μg 11 to 12 Days
$340.00
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Escherichia coli (E. coli) Human His tag Figure. SDS-PAGE; Sample: Active recombinant CLCA1, Human. 100 μg 15 to 18 Days
$1,280.00
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Escherichia coli (E. coli) Human Un-conjugated SDS-PAGE analysis of Human CLCA1 Protein. 100 μg 11 to 18 Days
$753.31
Details

CLCA1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Chloride Channel Accessory 1 (CLCA1) Interaction Partners

Human Chloride Channel Accessory 1 (CLCA1) interaction partners

  1. Results suggest that CLCA1 is involved in intestinal mucus homeostasis by facilitating processing and removal of mucus to prevent stagnation.

  2. CLCA1 suppresses colorectal cancer aggressiveness via inhibition of the Wnt/beta-catenin signaling pathway

  3. Increase in TMEM16A activity occurred within minutes of exposure to CLCA1 or after a short treatment with nocodazole, consistent with the hypothesis that CLCA1 stabilizes TMEM16A at the cell surface by preventing its internalization.

  4. Data show that calcium-activated chloride channel regulator 1 (CLCA1) and transmembrane protein 16A (TMEM16A) co-localize and physically interact and that CLCA1 increases the level of TMEM16A protein at the cell surface.

  5. inhibitor and siRNA transfection studies demonstrated an apparent effect of CLCA1 on ovarian cancer cell aggregation

  6. Results confirmed that the low expression of CLCA1 in CRC was associated with tumorigenesis, early metastasis, and high chromosomal instability. Low expression of CLCA1 predicts recurrence and lower survival.

  7. These findings demonstrate the ability of hCLCA1 to function as a signaling molecule and activate macrophages, central regulators of airway inflammation.

  8. CLCA1 may contribute to promoting spontaneous differentiation and reducing proliferation of Caco-2 cells.

  9. CLCA1 expression is significantly related to mucus production in the airway epithelia of smokers and COPD patients, and may contribute to the development and pathogenesis of COPD by inducing mucus production.

  10. These data provide both a mechanistic basis for CLCA1 self-cleavage and a novel mechanism for regulation of chloride channel activity specific to the mucosal interface.

  11. Increased expression of hCLCA1 in allergic rhinitis was correlated with the expression of MUC5AC.

  12. in cultured nasal airway cells, Th2 type cytokines increased hCLCA1 (calcium-activated chloride channel 1) expression in Cystic Fibrosis patients but not mucus expression

  13. The 357SS genotype was significantly overrepresented in both patients with meconium ileus and also with a severe CFTR genotype (P = 0.009) and in p.F508del homozygotes (P = 0.002).

  14. upregulation in the IL-9- responsive mucus-producing epithelium of asthmatic subjects supports the hypothesis that this channel may be responsible, in part, for the overproduction of mucus in asthmatic subjects

  15. transfection of Caco-2 human colon carcinoma cell line with pCLCA1 to investigate the regulation of CLCA-associated chloride conductance in this differentiated epithelial cell line

  16. hCLCA1 expression in NCI-H292 cells specifically induces soluble gel-forming mucin production. This Ca2+-activated Cl- channel plays an important role in epithelial-regulated inflammatory responses, including goblet cell metaplasia.

  17. polymorphisms in chronic obstructive pulmonary disease

  18. Variation of the CLCA1 gene affects patients' susceptibility for childhood and adult asthma in a Japanese population.

  19. CLCA1 and CLCA4 may have roles as modulators of the gastrointestinal basic defect in cystic fibrosis

  20. conclude that hCLCA1 and mCLCA3 are non-integral membrane proteins and therefore cannot be chloride channels in their own right

Horse (Equine) Chloride Channel Accessory 1 (CLCA1) interaction partners

  1. These data implicate CLCA1 in the expression of eqMUC5AC in horses; and suggest regulation by CLCA1 and epidermal growth factor receptor between horses with recurrent airway obstruction and those with milder degrees of inflammation.

  2. In this study, eCLCA1 protein and mRNA expression were quantified in airway goblet cells of horses with RAO and controls using immunohistochemistry and laser microdissection followed by RT-PCR, respectively.

Pig (Porcine) Chloride Channel Accessory 1 (CLCA1) interaction partners

  1. pCLCA1 shares essential characteristics of hCLCA1, supporting the pig model as a promising tool for studying the modulating role of pCLCA1 in the complex pathology of cystic fibrosis.

  2. pCLCA1 expression may increase the sensitivity of preexisting endogenous Cl(-) channels to Ca(2+) and cAMP agonists but apparently lacks inherent Cl(-) channel activity under growth conditions where endogenous channels are not expressed

Mouse (Murine) Chloride Channel Accessory 1 (CLCA1) interaction partners

  1. Results suggest that CLCA1 is involved in intestinal mucus homeostasis by facilitating processing and removal of mucus to prevent stagnation.

  2. The data underscore and specify the role of mouse CLCA1 in inflammatory airway disease to activate airway macrophages.

  3. These findings demonstrate that 10.1.1 Ab rapidly and specifically induces proliferation and growth of Lymph Node lymphatic sinuses and stroma, suggesting a key role of mCLCA1 in coordinating Lymph Node remodeling during immune responses.

  4. Clca1 is not required for mucus synthesis, structure and barrier function in the murine colon.

  5. mCLCA3 appears to modulate leukocyte response via IL-17 and murine CXCL-8 homologs in acute Staphylococcus aureus pneumonia which is well in line with the proposed function of hCLCA1 as a signaling molecule acting on alveolar macrophages.

  6. Findings suggest that increased expression of a single-gene, mCLCA3, could simulate an asthma attack, and its mechanism may involve mCLCA3 overexpression up-regulating IL-13 expression.

  7. PA-LPS-induced MUC5AC and Clca3 expression is partly through Duox1

  8. these findings argue against a role of mCLCA3 in Ca(2 )-activated Cl(-) channel-mediated Cl(-) secretion in murine respiratory epithelia

  9. Here, we have characterized the cleavage and autoproteolytic activity of the murine model protein mCLCA3

  10. Mclca3 mRNA was positively expressed in airway epithelium of asthmatic murine models with airway inflammationbut but was negatively expressed in control group. negatively expressed in control group (Figure 2).

  11. a functional link between two distinct anion currents, ClC-3 and swelling-activated chloride current

  12. Niflumic acid treatment during natural antigen-exposure, where mCLCA3 is greatly up-regulated in the lung, significantly reduces airway inflammation, goblet cell metaplasia and mucus overproduction in vivo.

  13. conclude that hCLCA1 and mCLCA3 are non-integral membrane proteins and therefore cannot be chloride channels in their own right

  14. Gob-5 expression is not essential for mucin overproduction in vitro or in murine models of allergic asthma

  15. We found that mClCA3 expression was significantly decreased in the colon and lung of the cftr-/- mice.

  16. demonstrated accumulation of mucus and increased mClca3 protein in the bronchiolar epithelium of asbestos-exposed mice at all time points but peaking at 9 days

  17. These observations reinforce findings that associate Gob-5 with goblet cell hyperplasia and mucus production in the allergic immune response, but also implicate Gob-5 in the regulation of tissue inflammation in the innate immune response.

  18. Primary 110-kDa translation product in the endoplasmic reticulum cleaves into a 75-kDa amino-terminal and a 35-kDa carboxyl-terminal protein that are glycosylated and remain physically associated with each other but cannot form a channel on their own.

  19. ClC-3 is not detectable on large dense-core vesicles of endocrine cells, but localizes to endosomes and synaptic-like microvesicles in both adrenal chromaffin and pancreatic beta cells.

Chloride Channel Accessory 1 (CLCA1) Protein Profile

Protein Summary

This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine.

Gene names and symbols associated with CLCA1

  • chloride channel accessory 1 (CLCA1)
  • chloride channel accessory 1 (Clca1)
  • chloride channel accessory 1 (clca1)
  • chloride channel (clcA1)
  • chloride channel protein (clcA1)
  • AECC protein
  • CACC protein
  • CaCC-1 protein
  • CACC1 protein
  • Clca1 protein
  • Clca2 protein
  • Clca3 protein
  • CLCRG1 protein
  • fi39d11 protein
  • gob-5 protein
  • gob5 protein
  • hCaCC-1 protein
  • hCLCA1 protein
  • wu:fi39d11 protein

Protein level used designations for CLCA1

CLCA family member 1, chloride channel regulator , calcium-activated chloride channel family member 1 , calcium-activated chloride channel protein 1 , calcium-activated chloride channel regulator 1 , calcium-dependent chloride channel-1 , chloride channel regulator 1 , chloride channel, calcium activated, family member 1 , calcium activated chloride channel 1 , calcium activated chloride channel-like protein 1 , chloride channel family member 1 , eCLCA1 , chloride channel calcium activated 3 , chloride channel accessory 1 , epithelial chloride channel protein , Clca1 protein , chloride channel , chloride channel protein , calcium-activated chloride channel regulator 1-like , calcium-activated chloride channel family member 3 , chloride channel calcium activated 2 , mCLCA3 , protein gob-5

GENE ID SPECIES
1179 Homo sapiens
456640 Pan troglodytes
490178 Canis lupus familiaris
507643 Bos taurus
574295 Macaca mulatta
100009706 Equus caballus
308015 Rattus norvegicus
334289 Danio rerio
397284 Sus scrofa
594875 Xenopus (Silurana) tropicalis
6321729 Xanthomonas campestris pv. campestris str. B100
9398586 Leuconostoc gasicomitatum LMG 18811
100386069 Callithrix jacchus
100442837 Pongo abelii
100604179 Nomascus leucogenys
23844 Mus musculus
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