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The protein encoded by CHDH is a choline dehydrogenase that localizes to the mitochondrion.
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The authors found that BMP2b and Chordin diffuse and rapidly form extracellular protein gradients, Chordin does not modulate the diffusivity or distribution of BMP2b, and Chordin is not required to establish peak levels of BMP signaling.
activation of the FGF signaling pathway induces the formation of a dorsal axis with a complete head structure through the expression of chd (show CHRD ELISA Kits) and subsequent maintenance of dkk1b (show DKK1 ELISA Kits) expression levels.
Binding of CV2 (show BMPER ELISA Kits) to Chordin (show CHRD ELISA Kits) promotes BMP-2 (show BMP4 ELISA Kits) signaling.
Targeted knockdown of Sox17 (show SOX17 ELISA Kits) and Chd (show CHRD ELISA Kits) in dorsal forerunner cells led to aberrant Left-Right (L-R) asymmetry establishment, as visualized by the expression of southpaw and lefty (show LEFTY2 ELISA Kits), and heart and pancreas placement in the embryo.
Chl (show CHRDL2 ELISA Kits), like Chd (show CHRD ELISA Kits), dorsalizes embryos upon overexpression and is cleaved by BMP1 (show BMP1 ELISA Kits); loss-of-function experiments show Chl (show CHRDL2 ELISA Kits) serves as a BMP antagonist with functions that overlap and are redundant with those of Chd (show CHRD ELISA Kits) in forming the dorsoventral axis.
Data show that The inhibition of Brorin-like functions in zebrafish resulted in the impairment of neural development.
by regulating the expression of her5, the Bmp2b (show BMP4 ELISA Kits)/Chordin (show CHRD ELISA Kits) gradient directs the anteroposterior patterning of endoderm in zebrafish embryos
chd, a bone morphogenetic protein antagonist expressed in gastrulation, is dispensable for neural crest induction.
Twisted gastrulation enhances BMP signaling through chordin (show CHRD ELISA Kits) dependent and independent mechanisms
specification of anterior neural tissue requires later activities of Chordin (show CHRD ELISA Kits) and mesodermal factors.
CHDH gene is located at chromosome 3p21.1, a risk region implicated in previous brains of bipolar disorder genome-wide association studies
In genotypic combination analysis considering PEMT (show PEMT ELISA Kits) -744GG/CHDH +432GG/BHMT +742GG as the reference combination, PEMT (show PEMT ELISA Kits) -744GC/CHDH +432GG/BHMT +742GG genotypic combination was significantly higher in mothers of a down syndrome child compared with that in control mothers with an odds ratio of 2.061 (95% CI: 1.10-3.86, P=0.0342).
CHDH is not a substrate of PARK2 (show PARK2 ELISA Kits) but interacts with SQSTM1 (show SQSTM1 ELISA Kits) independently of PARK2 (show PARK2 ELISA Kits) to recruit SQSTM1 (show SQSTM1 ELISA Kits) into depolarized mitochondria
the PEMT (show PEMT ELISA Kits) -774G>C and CHDH +432G>T polymorphisms were associated with sperm concentration. This finding suggests a possible influence of these genes on sperm quality
CHDH and PLD2 (show PLD2 ELISA Kits) as novel candidate genes, the nucleotide variants of which could be associated with the risk of tooth agenesis.
CHDH A119C and MTHFR (show MTHFR ELISA Kits) C677T play an important role in modulating the homocysteine levels in Indian population.
HOXB13, IL17BR, and CHDH are regulated by estrogen in breast cancer
single nucleotide polymorphisms of choline-metabolizing genes, PEMT (show PEMT ELISA Kits) -774G>C (rs12325817) and CHDH +432G>T (rs12676), were found be related to breast cancer risk
Data, including data from studies using transgenic/knockout mice, suggest that betaine accumulates during oocyte meiotic maturation; the mechanism appears to be transient activation of Chdh; Chdh is again inactive in the zygote (that is, after fertilization).
Loss of CHDH activity resulted in decreased testicular betaine and increased choline and PCho concentrations; impaired fertility was due to diminished sperm motility in the Chdh(-/-) males
The protein encoded by this gene is a choline dehydrogenase that localizes to the mitochondrion. Variations in this gene can affect susceptibility to choline deficiency. A few transcript variants have been found for this gene, but the full-length nature of only one has been characterized to date.
, dino (din)
, protein chordino
, choline dehydrogenase, mitochondrial
, choline dehydrogenase
, Choline dehydrogenase