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The protein encoded by CHDH is a choline dehydrogenase that localizes to the mitochondrion. Additionally we are shipping Choline Dehydrogenase Antibodies (34) and Choline Dehydrogenase Kits (2) and many more products for this protein.
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activation of the FGF signaling pathway induces the formation of a dorsal axis with a complete head structure through the expression of chd (show CHRD Proteins) and subsequent maintenance of dkk1b (show DKK1 Proteins) expression levels.
Binding of CV2 (show BMPER Proteins) to Chordin (show CHRD Proteins) promotes BMP-2 (show BMP4 Proteins) signaling.
Targeted knockdown of Sox17 (show SOX17 Proteins) and Chd (show CHRD Proteins) in dorsal forerunner cells led to aberrant Left-Right (L-R) asymmetry establishment, as visualized by the expression of southpaw and lefty (show LEFTY2 Proteins), and heart and pancreas placement in the embryo.
Chl (show CHRDL2 Proteins), like Chd (show CHRD Proteins), dorsalizes embryos upon overexpression and is cleaved by BMP1 (show BMP1 Proteins); loss-of-function experiments show Chl (show CHRDL2 Proteins) serves as a BMP antagonist with functions that overlap and are redundant with those of Chd (show CHRD Proteins) in forming the dorsoventral axis.
Data show that The inhibition of Brorin-like functions in zebrafish resulted in the impairment of neural development.
by regulating the expression of her5, the Bmp2b (show BMP4 Proteins)/Chordin (show CHRD Proteins) gradient directs the anteroposterior patterning of endoderm in zebrafish embryos
chd, a bone morphogenetic protein antagonist expressed in gastrulation, is dispensable for neural crest induction.
Twisted (show POMT2 Proteins) gastrulation enhances BMP signaling through chordin (show CHRD Proteins) dependent and independent mechanisms
specification of anterior neural tissue requires later activities of Chordin (show CHRD Proteins) and mesodermal factors.
While Chordin (show CHRD Proteins) is the main player of the D/V axis, the structures remaining in the chd (show CHRD Proteins) mutant in both mesodermal and ectodermal layers) result from the anti-Bmp activity carried by Nog1 (show NOG Proteins) and Fstl2 (show IGFBP7 Proteins) at blastula and gastrula stages.
In genotypic combination analysis considering PEMT (show PEMT Proteins) -744GG/CHDH +432GG/BHMT (show BHMT Proteins) +742GG as the reference combination, PEMT (show PEMT Proteins) -744GC/CHDH +432GG/BHMT (show BHMT Proteins) +742GG genotypic combination was significantly higher in mothers of a down syndrome child compared with that in control mothers with an odds ratio of 2.061 (95% CI: 1.10-3.86, P=0.0342).
CHDH is not a substrate of PARK2 (show PARK2 Proteins) but interacts with SQSTM1 (show SQSTM1 Proteins) independently of PARK2 (show PARK2 Proteins) to recruit SQSTM1 (show SQSTM1 Proteins) into depolarized mitochondria
the PEMT (show PEMT Proteins) -774G>C and CHDH +432G>T polymorphisms were associated with sperm concentration. This finding suggests a possible influence of these genes on sperm quality
CHDH and PLD2 (show PLD2 Proteins) as novel candidate genes, the nucleotide variants of which could be associated with the risk of tooth agenesis.
CHDH A119C and MTHFR (show MTHFR Proteins) C677T play an important role in modulating the homocysteine levels in Indian population.
HOXB13 (show HOXB13 Proteins), IL17BR, and CHDH are regulated by estrogen in breast cancer
single nucleotide polymorphisms of choline-metabolizing genes, PEMT (show PEMT Proteins) -774G>C (rs12325817) and CHDH +432G>T (rs12676), were found be related to breast cancer risk
Data, including data from studies using transgenic/knockout mice, suggest that betaine accumulates during oocyte meiotic maturation; the mechanism appears to be transient activation of Chdh; Chdh is again inactive in the zygote (that is, after fertilization).
Loss of CHDH activity resulted in decreased testicular betaine and increased choline and PCho concentrations; impaired fertility was due to diminished sperm motility in the Chdh(-/-) males
The protein encoded by this gene is a choline dehydrogenase that localizes to the mitochondrion. Variations in this gene can affect susceptibility to choline deficiency. A few transcript variants have been found for this gene, but the full-length nature of only one has been characterized to date.
, dino (din)
, protein chordino
, choline dehydrogenase, mitochondrial
, choline dehydrogenase
, Choline dehydrogenase