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The protein encoded by CHDH is a choline dehydrogenase that localizes to the mitochondrion. Additionally we are shipping Choline Dehydrogenase Antibodies (45) and Choline Dehydrogenase Kits (4) and many more products for this protein.
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There is no correlation between single CHDH rs893363 and CHDH rs2289205 polymorphisms and the incidence of intrauterine fetal death.
CHDH gene is located at chromosome 3p21.1, a risk region implicated in previous brains of bipolar disorder genome-wide association studies
In genotypic combination analysis considering PEMT -744GG/CHDH +432GG/BHMT +742GG as the reference combination, PEMT -744GC/CHDH +432GG/BHMT +742GG genotypic combination was significantly higher in mothers of a down syndrome child compared with that in control mothers with an odds ratio of 2.061 (95% CI: 1.10-3.86, P=0.0342).
CHDH is not a substrate of PARK2 (show PARK2 Proteins) but interacts with SQSTM1 (show SQSTM1 Proteins) independently of PARK2 (show PARK2 Proteins) to recruit SQSTM1 (show SQSTM1 Proteins) into depolarized mitochondria
the PEMT (show PEMT Proteins) -774G>C and CHDH +432G>T polymorphisms were associated with sperm concentration. This finding suggests a possible influence of these genes on sperm quality
CHDH and PLD2 (show PLD2 Proteins) as novel candidate genes, the nucleotide variants of which could be associated with the risk of tooth agenesis.
CHDH A119C and MTHFR (show MTHFR Proteins) C677T play an important role in modulating the homocysteine levels in Indian population.
HOXB13 (show HOXB13 Proteins), IL17BR, and CHDH are regulated by estrogen in breast cancer
single nucleotide polymorphisms of choline-metabolizing genes, PEMT (show PEMT Proteins) -774G>C (rs12325817) and CHDH +432G>T (rs12676), were found be related to breast cancer risk
Data, including data from studies using transgenic/knockout mice, suggest that betaine accumulates during oocyte meiotic maturation; the mechanism appears to be transient activation of Chdh; Chdh is again inactive in the zygote (that is, after fertilization).
Loss of CHDH activity resulted in decreased testicular betaine and increased choline and PCho concentrations; impaired fertility was due to diminished sperm motility in the Chdh(-/-) males
The protein encoded by this gene is a choline dehydrogenase that localizes to the mitochondrion. Variations in this gene can affect susceptibility to choline deficiency. A few transcript variants have been found for this gene, but the full-length nature of only one has been characterized to date.
, choline dehydrogenase, mitochondrial
, choline dehydrogenase
, Choline dehydrogenase