Choline Kinase alpha (CHKA) ELISA Kits

The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. Additionally we are shipping Choline Kinase alpha Antibodies (61) and Choline Kinase alpha Proteins (9) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
CHKA 1119 P35790
CHKA 12660 O54804
CHKA 29194 Q01134
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Top Choline Kinase alpha ELISA Kits at antibodies-online.com

Showing 3 out of 5 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Delivery Price Details
Human 3.9 pg/mL 15.63-1000 pg/mL Typical standard curve 96 Tests 15 to 18 Days
$910.56
Details
Rat 7.8 pg/mL 31.2-2000 pg/mL Typical standard curve 96 Tests 15 to 18 Days
$910.56
Details
Mouse
  96 Tests 15 to 18 Days
$875.60
Details

More ELISA Kits for Choline Kinase alpha Interaction Partners

Human Choline Kinase alpha (CHKA) interaction partners

  1. During proliferation, KDM2B binds to the Box2 located in the Chka promoter repressing its transcription. KDM2B knockdown enhances the levels of CKalpha expression in neuroblast cells and induces neuronal differentiation. These results suggest that KDM2B is required for the appropriate regulation of CKalpha during neuronal differentiation and to the maintaining of the undifferentiated stage of neuroblast cells.

  2. miR-876-5p was able to significantly decrease the expression level of choline kinase alpha mRNA.

  3. There is no correlation between single CHKA rs7928739 polymorphism and the incidence of intrauterine fetal death.

  4. This study presents the detail the 2.35 A structure of choline kinase alpha in complex with inhibitor TCD-717.

  5. Results indicate that choline kinase alpha (CHKA) contributes to tumor progression and metastasis and may serve as a prognostic biomarker and potential therapeutic target in colorectal carcinoma (CRC).

  6. hCKalpha functions as an indispensable regulator that bridges PI4KIIIalpha and hepatitis C virus NS5A and potentiates NS5A-stimulated PI4KIIIalpha activity, which then facilitates the targeting of the ternary complex to the endoplasmic reticulum for viral replication.

  7. We found levels of CHKA to be increased in human HCCs compared to nontumor tissues, and increased expression to be associated with tumor aggressiveness. Overexpression of CHKA in HCC cell lines increased their invasiveness, resistance to EGFR inhibitors, and ability to form metastatic tumors in mice by promoting interaction of EGFR with mechanistic target of rapamycin complex 2.

  8. These findings demonstrate that hCKalpha forms a complex with hepatitis C virus NS5A and that hCKalpha activity enhances the targeting of the complex to the endoplasmic reticulum, where hCKalpha protein, not activity, mediates NS5A binding to NS5B, thereby promoting functional membranous viral replication complex assembly and viral RNA replication.

  9. Study shows increased CHKA expression in pancreatic ductal adenocarcinoma tumors and may be a predictive marker of response to chemotherapy.

  10. These data also support the approach of antitumor strategies that destabilize Chk-alpha protein or downregulate PtdCho in breast cancer treatment.

  11. Downregulation of choline kinase-alpha enhances autophagy in tamoxifen-resistant breast cancer cells.

  12. CHKA can act as an AR chaperone, providing, to our knowledge, the first evidence for kinases as molecular chaperones, making CHKA both a marker of tumor progression and a potential therapeutic target for PCa.

  13. Identify choline kinase alpha as a key regulator of glutathione-dependent antioxidant cell defense in ovarian carcinoma.

  14. choline kinase alpha is inhibited by a near-infrared fluorescent carbocyanine

  15. Increased expression of CHKA is seen in malignant lesions of prostate cancer

  16. Chokalpha possessed oncogenic activity and could be a potential therapeutic target in T-cell lymphoma , as well as other hematological malignancies with interrupted Ras signaling pathways

  17. Downregulation of Chk-alpha with siRNA increased PLD1 expression, and downregulation of PLD1 increased Chk-alpha expression.

  18. there is a role for the ChoKalpha protein in promoting cancer cell survival that is independent of its catalytic activity.

  19. The significance of CHKA overexpression on a TMA.

  20. Our data suggest that choline kinase and its product phosphocholine are required for the normal growth and mineralization of MG-63 cells.

Mouse (Murine) Choline Kinase alpha (CHKA) interaction partners

  1. hepatic phosphatidylcholine is regulated by the circadian clock through a Bmal1-Rev-erbalpha-Chkalpha axis

  2. Enforced expression of either CK(alpha) or CCTalpha increased the rate of synthesis and the amount of PtdCho, and these cells initiated neuronal differentiation.

  3. Lack of muscle degeneration in forelimbs of Chkb(-/-) mice is due to abundant choline kinase alpha and the stable homeostasis of phosphatidylcholine.

  4. Experimental evidence for the presence of heteromeric ChoK/EtnK in any source. The activity of ChoK/EtnK in the cell is controlled not only by the level of each isoform but also by their combination to form the active oligomer complex.

  5. Full-length cDNAs or their truncated or alanine-mutated versions for mouse CK-alpha1 and CK-beta were expressed in COS-7 cells.

  6. ChoK may have a role in carcinogenesis

  7. Data suggest that the choline kinase alpha promoter has a distal element (-875/-867) that binds c-jun and the binding of c-jun is enhanced by treatment with CCl4.

  8. Chka is an essential gene for early embryonic development, but adult mice do not require full expression of the gene for normal levels of phosphatidylcholine.

Choline Kinase alpha (CHKA) Antigen Profile

Antigen Summary

The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation of ethanolamine. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Choline Kinase alpha (CHKA) ELISA Kits

  • choline kinase alpha (chka) antibody
  • choline kinase alpha (CHKA) antibody
  • choline kinase alpha (MCYG_00090) antibody
  • choline kinase (PF14_0020) antibody
  • choline kinase 1 (CK1) antibody
  • choline kinase (CNI01400) antibody
  • choline kinase alpha (Chka) antibody
  • ATCK1 antibody
  • Chetk-alpha antibody
  • Chk antibody
  • CHKA antibody
  • chkb antibody
  • ChoK antibody
  • CHOLINE KINASE antibody
  • choline kinase 1 antibody
  • CK antibody
  • CK-R antibody
  • CK/EK-alpha antibody
  • CKI antibody
  • EK antibody
  • EtnK-alpha antibody
  • F14O23.8 antibody
  • F14O23_8 antibody
  • im:7143625 antibody
  • si:dkey-12e7.3 antibody
  • wu:fd46h01 antibody

Protein level used designations for Choline Kinase alpha (CHKA) ELISA Kits

choline kinase alpha , choline kinase beta , choline kinase , CHETK-alpha , ethanolamine kinase , choline/ethanolamine kinase alpha , CK , EK , choline kinase R

GENE ID SPECIES
558499 Danio rerio
476002 Canis lupus familiaris
514865 Bos taurus
451376 Pan troglodytes
496957 Xenopus (Silurana) tropicalis
9223440 Arthroderma otae CBS 113480
811591 Plasmodium falciparum 3D7
843500 Arabidopsis thaliana
3259492 Cryptococcus neoformans var. neoformans JEC21
100013074 Monodelphis domestica
100059839 Equus caballus
100566078 Anolis carolinensis
100587988 Nomascus leucogenys
423112 Gallus gallus
1119 Homo sapiens
12660 Mus musculus
29194 Rattus norvegicus
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